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Moderate hypothermia appears ineffective for bacterial meningitis

...k to read the study in JAMA Relevant Reading: Induced hypothermia in adult community-acquired bacterial meningitis – more than just a possibility? In-Depth [randomized controlled trial]: This multicenter study examined 98 individuals, split into two groups, among 49 intensive care units in France. At 3 months 25 (51%) patients in the hypothermia group and 15 (31%) patients in the control group had died (RR, 1.99, 95%CI, 1.05-3.77; p= .04). Further...

Folate supplementation associated with reduced risk of spontaneous abortion

...egnancy supplemental folate intake at levels well beyond those currently recommended for the prevention of neural tube defects was not associated with increased risk of pregnancy loss; rather it may be an effective strategy to prevent spontaneous abortion.” In-Depth [prospective cohort]: Using data from the Nurses’ Health Study II, an ongoing prospective cohort study of female nurses ages 22-44, researchers identified all women who reported at lea...

Diets rich in omega fatty acids may reduce ALS (Lou Gehrig’s) risk

...MEC), and the National Institutes of Health–AARP Diet and Health Study (NIH-AARP). For several of these studies, ALS incidence was estimated through a search of death certificates. Information regarding the participants’ diets was recorded prospectively from each study in the form of a scale. Patients rated the approximate frequency of eating certain foods, and this was multiplied by the approximate size of the portions they consumed. Participants...

Opioid use associated with increased risk of invasive pneumococcal disease

...edicine Relevant Reading: Risk factors for invasive pneumococcal disease In-Depth [case-control study]: Researchers used data from TennCare, which is a Tennessee Medicaid database, to conduct a nested case-control study. The study included 1 233 IPD patients ≥5 years of age serving as cases. These cases were matched to 24 399 controls based on age, date of diagnosis, and county of residence. The authors used the ABCs system to find laboratory-conf...

Modulating lymphocyte populations decreases graft rejection in mice

Image: PD 1. A combination therapy of Campath, Rapamycin, and anti-IL-7 receptor blocking antibody induced tolerance of mismatched skin grafts in mice. 2. This combination therapy preferentially enriched T regulatory cells in a reconstituted T cell population. Study Rundown: While early animal studies suggested that T cell depletion before allotransplantation promoted graft tolerance, similar studies in humans have not found such success. The hom...

Wellness Check: Nutrition

...quency of headaches, and impact on quality of life. Patients on both the H3-L6 and H-3 diet had increased circulating oxylipin 17-hydroxydocosahexaeonic acid levels (associated with pain reduction) as well as decreased total headache hours per day. Interestingly, patients on H3-L6 diet also had decreased use of NSAIDs or aspirin compared to control. However, both H3-L6 and H3 diet did not lead to significantly changed quality of life compared to c...

Ranitidine may not lead to significant increase in N-nitrosodimethylamine in healthy adults

...excretion of NDMA with (paired difference -1.1ng, P=0.71) or without (0ng p-0.54) high-nitrite diet. Additionally, there were no difference in plasma NDMA level in ranitidine or placebo group. Although this was reassuring regarding the potential safety of ranitidine, this study was limited in its generalizability since it was not conducted with patients with gastric disease, whose stomach pH may result in slightly altered metabolism of ranitidine....

Argus retinal prosthesis "bionic eye" significantly improves vision in blind patients

...s medical engineering achievement is immense, as it provides tangible hope for the development of prostheses for other retinal diseases. Click to read the study in JAMA Ophthalmology [/tab] [tab] Image: PD 1. A total of 15/28 (54%) patients had a significant improvement in their ability to detect spatial motion with the use of the Argus II retinal prosthesis. 2. From this group, 91% of patients had a significant improvement in spatial motion detec...

Neladenoson does not increase exercise capacity for heart failure with preserved ejection fraction

...th [randomized controlled trial]: This was a phase 2b, randomized, parallel-group, dose-finding, double-blind, multi-center clinical trial. 305 patients were recruited at 76 centers in the United States, Europe, and Japan. Key inclusion criteria were age of 45 years or older, New York Heart Association functional class II, III, or IV HFpEF, and LVEF of 45% or greater. There were also key criteria to ensure adequate guideline-based therapy and base...

Receptor responsible for fertilization discovered

...ous research has identified the sperm surface protein (Izumo1) that allows for egg-sperm fusion, but this is the first research study to identify the receptor on the egg surface that binds Izumo1 and is involved in the acrosomal reaction. Discovery of the Juno-Izumo interaction marks the first identified protein pair necessary for gamete recognition in any organism. Further research to clarify additional necessary steps to allow for oocyte fertili...

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