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Novel antiviral drug reduces influenza viral load

...ecause some flu strains have developed resistance to Oseltamivir, the first-line flu antiviral. Therefore, developing a novel treatment of influenza is imperative. All strains of influenza virus enter respiratory epithelial cells by first binding sialic acid residues on the cell surface. In theory, disrupting this interaction should significantly inhibit the virus’ ability to infect. The novel agent DAS181 (Fludas) is an enzyme that binds and clea...

Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of...

1. Based on mathematical modeling, cross-reactivity between SARS-CoV-2 and other endemic human coronaviruses may explain variations in disease severity across age groups. Evidence Rating Level: 3 (Average) SARS-CoV-2 is the seventh known coronavirus to infect humans. Its resultant coronavirus disease 2019 (COVID-19) has resulted in over 400,000 deaths in the United States. With significant variations in symptom severity, based on a wide range of...

Patient Basics: Tuberculosis

...ain in the side (between the ribs and hip), frequent urination, pain or discomfort during urination, and blood in the urine. Disseminated or miliary tuberculosis – Symptoms include: Fever Night sweats Weight loss Weakness Lung problems (cough, shortness of breath, chest pain) Although the bacteria are spread throughout the body, there may not be any other symptoms. But if there are, they can occur nearly anywhere. Some of the more common symptoms...

Vitamin and supplement data remains limited, may provide no benefit

...es Task Force (USPSTF) concluded that there was insufficient evidence to recommend for or against the use of vitamins A, C, and E, multivitamins with folic acid, or antioxidant combinations for the prevention of CVD or cancer. Further, they recommended against the use of B-carotene supplements given evidence that these products may actually increase risk for developing lung cancer in vulnerable individuals. The current study reviewed additional ev...

Vitamin D deficiency linked with decreased pregnancy rates in IVF

...torage form of vitamin D (25-hydroxy vitamin D) to the biologically active form (1,23-dihydroxy vitamin D) are infertile, with uterine hypoplasia and absent corpora luteae. Existing data suggests vitamin D might play a role in fertility on one ore more levels by permitting cyclical oocyte development, embryo implantation, and/or physiologic hormone regulation across the hypothalamus-pituitary axis. It is known that most human reproductive organs c...

Oseltamivir treats avian flu early

...ntibiotics), time until treatment, and respiratory failure. The primary outcome for the study was death. The viral clade with the highest case fatality rate (CFR) was 2.1 circulating in Indonesia (85% of patients died). There was no significant difference in survival between sexes, but children less than 5 years of age had lower fatality rates than older patients. Additionally, patients who received treatment in less than two days after symptom on...

#VisualAbstract: Effect of Neladenoson Bialanate on Exercise Capacity Among Patients With Heart Failure With...

...th placebo. In addition, neladenoson did not improve activity intensity, NT-proBNP level, high-sensitivity troponin T level, or quality of life. Serious adverse effects were similar among groups. Though the study suggests neladenoson does not benefit HFpEF patients, some limitations should be noted. First, it is possible that longer treatment periods were needed to see an effect. Second, the lack of preclinical HFpEF models and mechanistic studies...

[In The News] Modest protection conferred by malaria vaccine in phase 3 trial

...d. No works may be reproduced without written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT. Content is produced in accordance with fair use copyrights solely and strictly f...

Rho kinase inhibitor safely reduces intraocular pressure

...e monitoring, Conventional Wnt signaling pathway is a potential new target for glaucoma therapeutics, Inhibition of molecular signaling in injured cornea hastens cell migration and wound closure, New point of care test highly sensitive and specific for adenoviral conjunctivitis, Argus II retinal prosthesis significantly improves spatial vision in blind patients, Artificial cornea is well retained in patients with ocular surface disease , High prev...

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