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Dexamethasone decreased mortality in hospitalized COVID-19 patients

...25.7%) (rate ratio, 0.83; 95% confidence interval [Ci], 0.75 to 0.93; P<0.001). Subgroup analysis showed there was no benefit in treating patients who did not receive respiratory support with dexamethasone (17.8%) compared to usual care alone (14.0%) (rate ratio, 1.19; 95% CI, 0.92 to 1.55). Furthermore, patients treated with dexamethasone (median, 12 days) had a shorter duration in the hospital compared to the control group (median, 13 days). Fi...

Convalescent plasma may not improve outcomes in Covid-19 patients

...019 (Covid-19) compared to placebo. 2. Convalescent plasma did not reduce 30-day mortality in patients with Covid-19 compared to placebo. Evidence Rating Level: 1 (Excellent) Study Rundown: The treatment of convalescent plasma is guided by the assumption of passive immunization jump starting the immune system in controlling disease evolution until a specific immune response is established. However, convalescent plasma treatment is only the standar...

#VisualAbstract: Malaria Chemoprevention Improves Postdischarge Management of Severe Anemia

...group (hazard ratio, 0.65; 95% confidence interval [CI], 0.54 to 0.78; P<0.0001). The readmission or death incidence was higher among participants with severe malarial anemia (41%) compared to children with nonmalarial anemia (9%); however, the difference was not significant. Finally, there were 284 serious adverse events in the chemoprevention group compared to the 534 events in the placebo group (P<0.001). Furthermore, 12 participants in the che...

Predicting mortality among septic patients presenting to the emergency department–a cross sectional analysis using...

...mode of arrival to the hospital, were found to be predictive of 7-day and 30-day mortality in septic patients. Evidence Rating Level: 3 (Average) Sepsis is associated with substantial morbidity and mortality worldwide. There are various scoring tools to predict sepsis mortality in the emergency department. However, these tools are based off vital signs and do not include patient presentation characteristics. This cross-sectional study sought to id...

Epidural labor analgesia not associated with increased risk of autism spectrum disorder in offspring

...th cohort study was performed in the province of Manitoba, Canada between 2005 and 2016 using data reported from four healthcare databases. Vaginal deliveries of singleton live infants born during the study period were screened and followed from birth until 2019 or censored by death or emigration. The study included 123,175 eligible offspring (62,647 boys, 50.9%) and the mean (SD) age of mothers at delivery was 28.2 (5.8) years. The mean follow-up...

Higher plasma levels of omega-3 fatty acids not associated with worse cardiovascular outcomes compared...

...ted individuals. Conversely, the STRENGTH trial randomly administered omega-3-carboxylic acid (CA), which increases EPA and DHA plasma levels, or corn oil placebo and discovered no difference in CV outcomes between groups. This post hoc analysis of the STRENGTH trial evaluated the association between CV outcomes and EPA and DHA levels. There were no significant differences in CV events between the highest tertile of plasma EPA levels or the highes...

Hydroxychloroquine may not prevent Covid-19 after contact exposure

...vid-19 exposure to a PCR-confirmed case patient. Participants who had Covid-19-like symptoms during the two weeks before enrollment were excluded from this study. The participants were randomized in a 1:1 ratio to receive hydroxychloroquine or usual care, respectively. The primary outcome was the onset of a PCR-confirmed, symptomatic Covid-19 episode. The participants were followed for 14 days. During the follow-up period, 64 of the 1,116 contacts...

Comparative efficacy of psychotherapies for reducing self-harm and suicidality in young individuals shows inconsistent...

...95 to 2020 with a median duration of treatment of 3 months (range, 0.25-12.00 months) and a median follow-up period of 12 months (range, 1-36 months). None of the investigated psychotherapies were associated with more study withdrawals when compared with treatment as usual. However, efficacy was inconsistent across outcomes and psychotherapies. Therefore, although the NMA found that most psychotherapies were well tolerated and efficacious for part...

Pregnancy outcomes in women with moderate-to-severe psoriasis

...rs) in the registry, there were 298 pregnancies from 220 patients between 2007 and 2019 (12,929 patient years). The fertility rate was 18.9 per 1000 women, which was lower than the general US population (59.1 per 1000 women). Out of the 298 pregnancies, there were 244 births including 1 stillborn (81.9%), 41 spontaneous abortions (13.8%), and 13 terminations (4.4%). 90.9% of live-births were full-term and 9.1% were premature. 94.7% of newborns wer...

Treatment with Percutaneous Coronary Intervention versus Coronary Artery Bypass not associated with increased rate...

...f 1 or 0.048 memory units/year, as 95% of cases in this study fell between -0.93 to 1.50. The study consisted of 1015 PCI participants and 665 CABG participants. Inverse probability-weighted cohort analysis showed groups were similar in BMI, smoking status, hypertension status, diabetes, depressive symptoms, pain, prior stroke, partnered status, level of education, race/ethnicity distribution, and percentage of wealth greater than cohort median. C...

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