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Residents of disadvantaged neighborhoods who are discharged from safety-net hospitals have high hospital readmission...

...tes After Medicare’s Hospital Readmissions Reduction Program Within Safety-Net and Non–Safety-Net Hospitals In-Depth [retrospective cohort]: The authors conducted a retrospective observational study utilizing Maryland’s data during the 2015 fiscal year (1 July 2014 to 30 June 2015). They assessed two main risk factors, hospital safety-net, which was defined as the mean disadvantage (mean ADI) of the hospital’s discharged patients, as well as the a...

Mass administration of ivermectin may decrease prevalence of scabies and impetigo

...ficant decrease in scabies prevalence in the standard care, permethrin and ivermectin groups. However, the greatest reduction was seen in the ivermectin group with a relative reduction rate of 94%. The prevalence of impetigo also declined in all study groups, with the greatest relative reduction of 67% in the ivermectin group. Mild adverse events were reported and occurred most frequently in the ivermectin group. Strengths of this study include tr...

Internet-based cognitive behavioral therapy effective for body dysmorphic disorder

...ever, this was the largest RCT to date to analyze the effectiveness of BDD-NET and support the use of BDD-NET as a novel method of delivering CBT in the treatment of BDD. Click to read the study in the BMJ Relevant Reading: Therapist-supported Internet cognitive behavioural therapy for anxiety disorders in adults In-Depth [randomized controlled trial]: This was a single-blind randomized controlled trial of BDD-NET compared to online supportive the...

Insecticidal bed nets linked with reduced transmission of lymphatic filariasis

...filarial medication treatments between 1994 through 1998. A nationwide bed-net intervention in 2009 led to an increase in self-reported bed net usage from 3.8% to 12.4% to 75.0 to 90.6% of households. 20, 345 anopheline mosquitoes were collected in the 26 months before bed-net distribution, and 1,554 in the 11 months after distribution; 2 villages were selected for long-term assessment of mosquito biting rates up to 3 years following intervention....

#VisualAbstract: Safety-Net Hospitals, Neighborhood Disadvantage, and Readmissions Under Maryland’s All-Payer Program

...er association observed between readmission risk and the hospital’s safety-net index compared to the patient’s neighborhood disadvantage status. Evidence Rating Level: 2 (Good) Study Rundown: The term safety-net hospital refers to a center that cares for a large number of significantly disadvantaged patients. The authors of this study evaluated the independent contributions of patients’ neighborhoods and the hospital’s service area with respect to...

Rivaroxaban has no net clinical benefit over enoxaparin for thromboprophylaxis in acutely ill patients

...ly relevant bleeding compared to enoxaparin. The study did not establish a net clinical benefit of choosing rivaroxaban over enoxaparin after accounting for both efficacy and safety. This study affirms that an optimal treatment for thromboprophylaxis has yet to emerge. Better patient stratification based on bleeding risks is needed in order to maximize the clinical benefit of rivaroxaban. Click to read the study in NEJM [/tab] [tab] Image: PD 1. R...

USPSTF Update: Screening adults for unhealthy drug use has moderate net benefit

...er the age of 18 for unhealthy drug use by asking questions had a moderate net benefit, if patients can be provided with further diagnostic testing, treatment, and supportive care. They suggested clinicians consider the use of screening tools such as NIDA Quick Screen, ASSIST, TAPS, and PRO. Additionally, treatment with pharmacotherapy, including buprenorphine, methadone, and naltrexone for opioid use disorder reduced relapse rate and improved ret...

Daily aspirin may benefit some patients without existing cardiovascular disease

...n or death from a CVD event and major bleed are considered equivalent, the net benefit from aspirin ranged from 0.0% to 28.5% in women and 0.1% to 50% among men (using the upper and lower limits of 95% CIs). Greater net benefits were seen in subgroups that were older, current smokers, had diabetes, or were receiving blood pressure or lipid lowering medication. If 1 CVD event was considered equivalent to 2 major bleeds, the net benefit from aspirin...

Neuroendocrine tumor marker pancreastatin may be predictive of survival

...udy Rundown: Tumor resection remains the first-line therapy for pancreatic NETs (PNETs) or small bowel NETs (SBNETs), though recurrence rates are high. The ability to predict the response and survival of patients after tumor resection may aid clinicians in determining subsequent treatment courses (e.g. more or less aggressive therapies). This study examined the potential of NET biomarkers to predict patient outcomes after surgery. They found that...

[Physician Comment] Low dose aspirin shows net clinical benefit in patients with first unprovoked...

...In 77% of cases the venous thromboembolism was unprovoked. The significant net clinical benefit of aspirin was demonstrated as a 33% composite reduction in the rate of venous thromboembolism, myocardial infarction, stroke, major bleeding, or death (95% CI, P=0.01). In sum: Daily low dose aspirin is known for its beneficial cardiovascular effects. This study suggests that aspirin can be used not only to help prevent major cardiovascular effects but...

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