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Modelling study suggests that statins may be overprescribed

...study also identified the expected risk under which statins do not provide net benefit. Generally, this modelling study suggested that statins may be significantly overprescribed in that it showed that a net benefit of statins was derived at a higher than expected risk level. The main limitation of this study was that not all age-specific data for all components of the study were available. Click to read the study in Annals of Internal Medicine Re...

Pancreatic cancer screening with MRI may benefit high-risk patients

...development into pancreatic malignancy, and likelihood of detection on magnetic resonance imaging, including false-negative and false-positive data, was included in the model for each precursor among various populations ranging from average risk individuals to those with positive first-degree family history or genetic cancer syndromes. Each simulation followed a hypothetical group of 20-year-olds until 99 years of age, and multiple cycles were ru...

2 Minute Medicine Rewind December 14, 2015

...oup, RR reduction 0.62, 95% CI 0.49 to 0.75, and 32.1% to 1.9% in the mass ivermectin treatment group, RR reduction 0.94, 95% CI 0.83 to 1.0). Complications of scabies such as the prevalence of impetigo also decreased. Each treatment therapy was effective in decreasing the prevalence of scabies, however mass administration of ivermectin was the most efficacious in reducing scabies and impetigo incidence. Comparison of Intended Scope of Practice fo...

2 Minute Medicine Rewind April 16, 2018

...WHO) recommends only the pyrethroid class of insecticides for long-lasting nets, but a new net using piperonyl butoxide (PBO) has been developed. In this randomized controlled trial, investigators randomized participants in 40 villages (29,365 households for a total population of 135,900) to either PBO long-lasting insecticidal nets or standard nets with or without indoor residual spraying. The primary outcome measured was the prevalence of Plasmo...

All-cause mortality is increased for older adults with sudden loss of wealth in the...

...ock exacerbated the increased mortality rate. Sex, ethnicity, and baseline net worth did not significantly influence the association of wealth shock and increased mortality. This study found a clear association between wealth shock towards the end of life and increased mortality, further suggesting that socioeconomic status greatly affects health. While this association seems robust, future studies will be needed to determine how wealth shock lead...

Self-measured blood pressure monitoring lowers pressures compared to typical clinical monitoring

...g SMBP monitoring to usual care, a lower BP was observed at 6 months (mean net reduction -3.9 mmHg systolic and -2.4 mmHg diastolic; p<0.001). However, significance was not seen at 12 months (-1.5 mmHg systolic and -0.8 mmHg diastolic). When comparing SMBP monitoring with additional support vs. usual care, a lower BP was still significant at 12 months (Ranging between -3.4 to -8.9 mmHg systolic and -3.9 to -4.4 mmHg diastolic). However, in the lat...

The TRITON trial: Prasugrel vs clopidogrel in ACS [Classics Series]

...ugrel, stratification of groups revealed that prasugrel showed no clinical net benefit for patients who had a prior history of CVA/TIA, are above 75 years of age, or are below 60 kg for weight. In summary, this study showed that prasugrel is more effective than clopidogrel in preventing recurrent myocardial infarctions and subsequent deaths, but also increases the risk of major bleeding. Overall, the net clinical benefit of prasugrel provides evid...

Global surveillance of cancer trends reveals wide variances in survival rate [CONCORD-2 study]

..., population-based cancer registries across 67 countries were analyzed for net 5-year survivals. Survival trends for 10 different types of invasive primary cancer comprising roughly two-thirds of the global cancer burden were assessed. Wide differences were apparent in survival trends, likely due to inequity of access to timely diagnosis and treatment. For example, 5-year survival for prostate cancer varied from below 60% in Thailand to more than...

USPSTF recommends routinely screening asymptomatic women for chlamydia and gonorrhea

...females who are 24 years or younger and sexually active provides moderate net benefit. Older women at high-risk (i.e., those with multiple sex partners, the incarcerated, recent military recruits, and those obtaining care at free STI clinics) would also benefit from screening. There was inadequate evidence to assess the value of screening for these STIs in men. It was noted that screening of pregnant women to avoid ophthalmia neonatorum provided...

Nusinersen improves motor function in children with later-onset spinal muscular atrophy: The CHERISH trial

...r function) and decreased in the placebo group (-1.9 points), leading to a net difference of 5.9 points between the two treatment arms (95% confidence interval [CI], 3.7 to 8.1, p < 0.001). This net difference during the study’s final analysis confirmed the interim results (+3.9 points nusinersen; -1.0 control; mean difference 4.9 points, 95% CI, 3.1 to 6.7). A higher percentage of children assigned to the nusinersen treatment arm were noted to ha...

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