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Intervention to reduce low-value preoperative care for patients undergoing cataract surgery

...his multi-component quality improvement project run at two academic safety-net health systems in California, the educational interventions yielded cost savings of $42,241 after 1 year at LAC-USC (Los Angeles County and University of Southern California) Medical Center with 3 year estimate at $67,241. In a fee-for-service system, 3 year loss of earnings was estimated at $88,151 however societal cost savings were $217,322. Pre-operative visits, ches...

IV alteplase improves functional outcomes in patients with stroke of unknown onset

...h unknown time of stroke onset for IV thrombolysis have shown promise with net clinical benefit. This systematic review and meta-analysis included individual patient data from four randomized-controlled trials comparing IV alteplase with placebo or standard of care in adults with stroke of unknown time of onset. Patients were selected using imaging biomarkers (MRI diffusion weighted imaging-fluid attenuated inversion recovery [DWI-FLAIR] mismatch...

Quick Take: Neoadjuvant degarelix versus triptorelin in premenopausal patients who receive letrozole for locally...

...s with breast cancer receiving letrozole as neoadjuvant endocrine therapy (NET). In this randomized controlled trial, 51 premenopausal women with stage cT2 to 4b, estrogen receptor and progesterone receptor greater than 50%, and human epidermal growth factor receptor 2-negative invasive breast cancer were randomized to receive triptorelin 3.75 mg (administered intramuscularly on day 1 of every cycle) or degarelix 240 mg (administered subcutaneousl...

Thrombolysis for pulmonary embolism may benefit younger patients, harm older patients

...different end-points. While this study suggested that thrombolysis have a net benefit for younger patients and net harm for older patients, further research is required before incorporating these results at the bedside. Click to read the study, published today in JAMA Relevant Reading: Systemic thrombolytic therapy for acute pulmonary embolism: a systematic review and meta-analysis In-Depth [systematic review and meta-analysis]: This study includ...

#VisualAbstract: Neoadjuvant degarelix versus triptorelin in premenopausal patients who receive letrozole for locally advanced...

...s with breast cancer receiving letrozole as neoadjuvant endocrine therapy (NET). In this randomized controlled trial, 51 premenopausal women with stage cT2 to 4b, estrogen receptor and progesterone receptor greater than 50%, and human epidermal growth factor receptor 2-negative invasive breast cancer were randomized to receive triptorelin 3.75 mg (administered intramuscularly on day 1 of every cycle) or degarelix 240 mg (administered subcutaneousl...

Fibrosis linked with mortality in nonischemic dilated cardiomyopathy patients

...correct risk reclassifications using the proposed schema by the authors. Nonetheless, this study provides a solid foundation for the potential clinical use of midwall fibrosis as a mortality predictor in dilated cardiomyopathy patients. Click to read the study, published today in JAMA By John Prendergass and Rif Rahman More from this author: Protected sleep periods improve intern alertness and sleep duration , ADHD medication decreases rates of cr...

2 Minute Medicine Rewind October 20 – October 27, 2014

...o the practices owned by local hospital or multi-hospital organizations. Genetic and Environmental Risk Assessment and Colorectal Cancer Screening in an Average-Risk Population Adherence to chronic screening programs, including the colorectal cancer screening, remains a significant problem. The use of individualized genetic and environmental risk assessments (GERA) for colorectal cancer susceptibility has been thought to possibly improve adherence...

Chest radiograph neural network predicts lung cancer in smokers

...y to non-smokers. In summary, this study demonstrated that a deep-learning network based on electronic health data is comparable to current high performing models without smoking history as an input. Click here to read the study, published today in Annals of Internal Medicine Relevant Reading: Selection Criteria for Lung-Cancer Screening In-Depth [retrospective cohort]: This study trained a neural network using the PLCO (Prostate, Lung, Colorectal...

2 Minute Medicine Rewind December 31, 2018

...s with breast cancer receiving letrozole as neoadjuvant endocrine therapy (NET). In this randomized controlled trial, 51 premenopausal women with stage cT2 to 4b, estrogen receptor and progesterone receptor greater than 50%, and human epidermal growth factor receptor 2-negative invasive breast cancer were randomized to receive triptorelin 3.75 mg (administered intramuscularly on day 1 of every cycle) or degarelix 240 mg (administered subcutaneousl...

Physicians report feeling moral distress over hospital policies that force inadequate care based on...

...has several limitations. First, the study was conducted in only two safety net systems, and it may not be applicable to other training environments. Furthermore, there may have been an inherent response bias from participants, where negative experiences and perceptions were minimized due to social desirability. Strengths of this study include that it looked to evaluate clinicians’ experiences with this policy, rather than only the patients’ experi...

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