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2 Minute Medicine Rewind June 29, 2020

...students 1. Higher frequency, intensity, and duration of physical exercise linked to lower risk of chronic pain in Norwegian University students Evidence Rating: 3 (Average) Chronic pain is estimated to impact around one-third of the population, and is a leading cause of disability worldwide. There has been mixed evidence on the link between physical activity and chronic pain, in part due to the varied methods in which chronic pain is measured and...

2 Minute Medicine Rewind October 12, 2020

...r hemorrhage, pre-hospital administration of tranexamic acid did not significantly improve 30-day mortality compared to a placebo. 2. 30-day mortality outcomes were higher in the treatment group, when tranexamic acid was administered within 1 hour of injury, when the patient underwent severe shock, or when 2 g of tranexamic acid were administered within 8 hours of hospital arrival. Evidence Rating Level: 1 (Excellent) In the treatment of trauma pa...

2 Minute Medicine Rewind February 22, 2021

...ale) cohorts each included 6,034 patients. Dementia was diagnosed in significantly fewer patients in the NOAC cohort than in the warfarin cohort (304 vs. 360, p = 0.0285). Furthermore, in a stratified analysis, the risk of dementia was lower among patients using NOACs when compared with warfarin if aged 65 to 74 years, if at a high risk of stroke as measured by the CHA2DS2-VASc score, and if at a high risk of bleeding as measured by the HAS-BLED s...

2 Minute Medicine Rewind February 8, 2021

...on the rise for middle-aged patients, although TKR done too early has been linked to lower patient satisfaction and greater risk of prosthesis infection. In fact, 25% of TKR procedures are classified as “likely inappropriate”, underlying the need for alternative knee OA treatments. A procedure known as high tibial osteotomy (HTO) has been used to postpone the need for a TKR, although it is not commonly performed in Canada. In this single-center pr...

2 Minute Medicine Rewind September 21, 2020

...ompared to 1.53% of patients in the usual care group. This was not a significant difference (Odds Ratio 1.06, 95% CI 0.84-1.35, P = 0.60). Therefore, an opportunistic screening protocol did not impact AF diagnostic rates, which highlights the need for exploring other methods to diagnose patients early, such as through targeted screening or heart rhythm monitoring through common wireless devices. Life’s Simple 7 and Incident Hypertension: The REGAR...

2 Minute Medicine Rewind July 13, 2020

...ions, and for the posterior circulation (ICASPC) 3.8±3.0 lesions. No significant association between ICASTC and memory was found (b = -0.02 per +1 lesion, 95% CI -0.05 to 0.00, where b is a linear regression coefficient representing the difference in Z-score per one lesion increase in ICAS burden), even after controlling for age, sex, education level, and reading ability. However, a significant association between ICASPC and memory was observed (b...

2 Minute Medicine Rewind May 18, 2020

...y is a common and often chronic mental health problem, and affects a significant portion of the population. Current first line therapy involves face-to-face cognitive behavior therapy (CBT), and though this method is often found to be an effective management strategy, constant face-to-face CBT incurs significant costs, requires greater commitment (standard is weekly appointments over 3 months), and may be out of reach to populations with reduced h...

2 Minute Medicine Rewind December 7, 2020

...trial 1. Hyoscine butylbromide and acetaminophen have comparable and significant analgesic effects for pediatric non-specific colicky abdominal pain. Evidence Rating Level: 1 (Excellent) Cases of pediatric abdominal pain are a daily occurrence in hospital emergency wards. However, current analgesic recommendations for pediatric abdominal pain are not being adhered to, with two-thirds of patients not receiving any analgesia, and approximately half...

Special Rewind: COVID-19 Vaccine Edition. December 21, 2020

...e first vaccination and were shown to be dose-dependent with day 29 enzyme-linked immunosorbent assay anti-S2P antibody geometric mean titer (GMT) of 40,227(25μg), 109,209 (100μg), and 213,526 (250μg). Day 57 GMT, following the second vaccination, titers increased further to 299,751(25μg), 782,719(100μg), and 1,192,154(250μg). Serum-neutralizing activity was detected in all participants via two methods. Fatigue, myalgia, chills, headache, and pain...

2 Minute Medicine Rewind January 11, 2021

...ior to COVID-19 diagnosis). The results found 69 diagnoses that were significantly associated with COVID-19 diagnosis. As expected, the most common diagnoses included respiratory conditions, such as viral pneumonia (odds ratio 177.63, 95% CI 147.19–214.37, absolute risk 27.6%) and respiratory failure (OR 11.36, 95% CI 10.74–12.02, absolute risk 22.6%), in addition to other common conditions such as acute kidney failure (OR 3.50, 95% CI 3.34–3.68,...

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