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2 Minute Medicine Rewind March 8, 2021

...d bleed was shown to reduce thrombosis and all-cause mortality rates significantly.   Identifying at‐risk patients for sustained atrial high‐rate episodes using the C2HEST Score: The West Birmingham Atrial Fibrillation Project 1. The C2HEST score had moderate accuracy in predicting sustained atrial high-rate episodes (SAHREs) for patients with cardiac implantable electronic devices, but no atrial fibrillation. 2. A 1-point increase in the C2HEST s...

2 Minute Medicine Rewind November 16, 2020

...have epidural anesthesia or not during labor 1. A decision aid tool significantly helped resolve decision conflict in patients contemplating the use of epidural anesthesia during labour. Evidence Rating Level: 1 (Excellent) In Japan, analgesic use in delivery of babies is low compared to other countries, with only 6.2% of women receiving epidural anesthesia in 2016. This could stem from a variety of reasons, such as few hospitals where epidurals...

2 Minute Medicine Rewind March 23, 2020

...years) from two hospitals in Wuhan, China who had confirmed COVID-19 and either passed away or were discharged by January 31, 2020. With demographic, laboratory (serial samples for viral RNA detection), clinical, and treatment data from electronic medical records, researchers intended to compare survivors and non-survivors. A total of 191 patients were included in this study (median [IQR] age = 56.0 [46.0 to 67.0] years, 38% female), 71.7% of who...

2 Minute Medicine Rewind August 10, 2020

...patients (mean [SD] age = 67.8 [11.3] years, 66.1% female) who underwent either primary repair or secondary revision of a symptomatic PEH using a robotic surgery approach. Primary outcomes assessed serially over five years included the gastroesophageal reflux disease-health related quality of life questionnaire (GERD-HRQL) score, a standardized symptom questionnaire, and screening for recurrence with an esophagram. Five-year post-operative data w...

2 Minute Medicine Rewind April 13, 2020

...Hospital-Onset or Community-Onset Sepsis 1. Sepsis bundles were not significantly associated with decreased risk of mortality or reduced vasopressor treatment time in community- or hospital-onset sepsis. 2. Components of the SEP-1 bundle, such as broad-spectrum IV antibiotic treatment and lactate levels were associated with improved outcomes in this population. Evidence Rating Level: 2 (Good) Sepsis bundles, or protocols involving multiple interv...

2 Minute Medicine Rewind April 5, 2021

...tibody and PD1/L1 inhibitor, when combined with chemotherapy, showed significantly prolonged progression free survival and higher objective response rate, compared with chemotherapy alone. Evidence Rating Level: 1 (Excellent) Squamous non-small-cell lung cancers (sq-NSCLCs) are often diagnosed at a later stage, leading to poor prognosis and difficult disease management. However, there has been promise shown when combining chemotherapy with monoclo...

2 Minute Medicine Rewind August 24, 2020

...g children around the world. In the past, genetics were considered a significant risk factor due to children of asthmatic parents being more likely to have asthma themselves. However, rapidly increasing rates of asthma indicate that environmental and societal factors may be important to consider as well. Specifically, environmental factors such as air pollution and urbanisation, and family factors such as exposure to smoking, socioeconomic status...

2 Minute Medicine Rewind August 17, 2020

...rt study, 2512 hospitalized SARS-CoV 2 PCR-positive patients had received either hydroxychloroquine, hydroxychloroquine and azithromycin, azithromycin or neither therapy and the association with associated death was examined. Patients hospitalized between March 1 2020 to April 22, 2020 were chosen and followed-up with until May 5, 2020. Propensity-score adjusted analysis did not show decrease mortality with hydroxychloroquine (aHR 1.02, 95% 0.82-1...

2 Minute Medicine Rewind July 27, 2020

...long been associated with negative health outcomes, such as obesity, Type II diabetes mellitus, and cardiovascular disease. However, there have been mixed results in associating artificially sweetened beverages (ASBs) to these outcomes. A particular concern is that consuming ASBs may contribute to a stronger preference for consuming sugary foods. Reducing refined sugar consumption is correlated with lower ratios of serum triglyceride to high-dens...

2 Minute Medicine Rewind January 25, 2021

...without concomitant benign prostatic hyperplasia, tamsulosin therapy significantly reduced the symptoms of overactive bladder. Evidence Rating Level: 2 (Good) Lower urinary tract symptoms (LUTS) are common among older male adults and are most commonly attributed to either benign prostatic hyperplasic (BPH) or overactive bladder (OAB). Though there is significant overlap between the two pathologies in terms of signs and symptoms, it is recommended...

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