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Renin-angiotensin-aldosterone system inhibitors do not affect COVID-19 risk

..., 0.87 to 1.07) and ARBs (0.95, 95% CI, 0.86 to 1.05) did not have a significant association with COVID-19 risk. Furthermore, other antihypertensive medications such as beta blockers (0.99, 95% CI, 0.91 to 1.08) and thiazides (1.03, 95% CI, 0.86 to 1.23), also, did not have a significant association with COVID-19 risk. Additionally, neither monotherapy (1.03, 95% CI, 0.90 to 1.18) nor combination therapy (0.99, 95% CI, 0.90 to 1.09) use of the ant...

#VisualAbstract: Duration of Initial Empirical Antibiotic Therapy and Outcomes in Very Low Birth Weight...

...h weight (VLBW) infants who received antibiotics for 4 to 7 days had significant increased odds of short term morbidity and mortality. 2. Each day of antibiotic use among VLBW infants was associated with about 5% greater odds of major adverse outcomes. Evidence Rating: 2 (Good) Study Rundown: Early onset sepsis (EOS) is a serious problem among VLBW neonates, therefore providers often initiate empiric antibiotics. These medications are usually disc...

#VisualAbstract: Serum antibody testing for SARS-CoV-2

...ed the SARS-CoV-2 spike protein serum assay’s ability to present antibody kinetics and subsequent clinical use. Results from antibody testing were able to provide diagnostic patient support when patients had tested negative through NAAT but remained at clinical suspicion for COVID-19. This case-control study was limited by its sampling of hospitalized patients. The convenience sampling in the study created a bias since patients who were asymptomat...

No difference in safety or efficacy of low-dose alteplase for treatment of lacunar acute...

...ong patients in the “definite” subgroup of lacunar AIS, there was no significant difference between the low- and standard-dose alteplase groups, nor was there a significant difference with regards to major disability or death. It should be noted, however, that only five participants experienced ICH between both the low- and standard-dose cohorts. Strengths of this analysis include utilizing data from a large, prospective study with multiple adjust...

Association of potent topical corticosteroids and the risk of osteoporosis and major osteoporotic fractures

...251 adults (mean [SD] age = 52.8 [19.2] years, 52.8% female) treated with either potent or very potent TCSs. Filled prescription data were converted in equipotent doses to mometasone furoate (1 mg/g). Included participants were treated with the equivalent of at least 200 g of mometasone. The primary outcome was a diagnosis of osteoporosis or MOF. 25.8% of participants were exposed to 500-999 g of mometasone; 15.4% to 1,000-1,999 g; 13.0% to 2,000-...

RSV vaccination in third trimester associated with significantly reduced infection risk in early months...

...frameworks. From past research, households have been identified as a significant contributor to RSV transmission, but modelling studies have not been conducted on high-income settings yet. The current study’s goal was to model the household-level impact of maternal RSV vaccines in a high-income country. This involved combining Australian census data with a model for RSV transmission, accounting for household and community population mixing, and de...

Rapid antigen testing for SARS-CoV-2 infection found to have limited accuracy for a pediatric...

...cohort, rapid antigen testing for SARS-CoV-2 infection was found to have limited accuracy when compared with reverse-transcriptase polymerase chain reaction testing. Evidence Level Rating: 2 (Good) Since the start of the COVID-19 pandemic, reverse-transcriptase polymerase chain reaction (RT-PCR) testing performed on nasopharyngeal swabs has been the most widely used means of establishing the presence of infection. The Panbio™ COVID-19 Antigen (Ag...

Tocilizumab not superior to standard care in randomized controlled trial for severe COVID-19 patients

...the disease presents with mild to no symptoms in most individuals, a significant number develop pneumonia that progresses to complications. These include complications such as respiratory failure, shock, organ failure that can lead to death, contributing to over 2 million deaths worldwide. One of the current hypotheses surrounding the downstream complications of COVID-19 are that they result from a host immune response involving inflammatory cytok...

Dexamethasone decreased mortality in hospitalized COVID-19 patients

...talized with COVID-19. The study determined mortality at 28 days was significantly lower in the dexamethasone group compared to the usual care group. Additionally, no benefit was found amongst patients who did not require oxygen. Patients treated with dexamethasone were also noted to have a shorter duration in their hospital stay and a greater probability of being discharged within 28 days. The study was limited by the lack of long-term follow-up...

Advanced care planning intervention for patients with advanced lung or colorectal cancer

...colorectal cancer. 2. ACP was found to increase the number of patients receiving specialized palliative care, and having advanced directives recorded in hospital files. Evidence Rating Level: 1 (Excellent) Discussions regarding end-of-life plans among patients, family, and healthcare professionals are associated with numerous positive outcomes, such as better emotional functioning, increased symptom resolution, and less demanding interventions. Ad...

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