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2 Minute Medicine Rewind December 7, 2020

...trial 1. Hyoscine butylbromide and acetaminophen have comparable and significant analgesic effects for pediatric non-specific colicky abdominal pain. Evidence Rating Level: 1 (Excellent) Cases of pediatric abdominal pain are a daily occurrence in hospital emergency wards. However, current analgesic recommendations for pediatric abdominal pain are not being adhered to, with two-thirds of patients not receiving any analgesia, and approximately half...

2 Minute Medicine Rewind June 29, 2020

...students 1. Higher frequency, intensity, and duration of physical exercise linked to lower risk of chronic pain in Norwegian University students Evidence Rating: 3 (Average) Chronic pain is estimated to impact around one-third of the population, and is a leading cause of disability worldwide. There has been mixed evidence on the link between physical activity and chronic pain, in part due to the varied methods in which chronic pain is measured and...

2 Minute Medicine Rewind July 27, 2020

...long been associated with negative health outcomes, such as obesity, Type II diabetes mellitus, and cardiovascular disease. However, there have been mixed results in associating artificially sweetened beverages (ASBs) to these outcomes. A particular concern is that consuming ASBs may contribute to a stronger preference for consuming sugary foods. Reducing refined sugar consumption is correlated with lower ratios of serum triglyceride to high-dens...

2 Minute Medicine Rewind October 12, 2020

...r hemorrhage, pre-hospital administration of tranexamic acid did not significantly improve 30-day mortality compared to a placebo. 2. 30-day mortality outcomes were higher in the treatment group, when tranexamic acid was administered within 1 hour of injury, when the patient underwent severe shock, or when 2 g of tranexamic acid were administered within 8 hours of hospital arrival. Evidence Rating Level: 1 (Excellent) In the treatment of trauma pa...

2 Minute Medicine Rewind September 21, 2020

...ompared to 1.53% of patients in the usual care group. This was not a significant difference (Odds Ratio 1.06, 95% CI 0.84-1.35, P = 0.60). Therefore, an opportunistic screening protocol did not impact AF diagnostic rates, which highlights the need for exploring other methods to diagnose patients early, such as through targeted screening or heart rhythm monitoring through common wireless devices. Life’s Simple 7 and Incident Hypertension: The REGAR...

2 Minute Medicine Rewind August 24, 2020

...g children around the world. In the past, genetics were considered a significant risk factor due to children of asthmatic parents being more likely to have asthma themselves. However, rapidly increasing rates of asthma indicate that environmental and societal factors may be important to consider as well. Specifically, environmental factors such as air pollution and urbanisation, and family factors such as exposure to smoking, socioeconomic status...

2 Minute Medicine Rewind October 19, 2020

...ls (53.1 nmol/L vs. 69.9 nmol/L, p=0.02). There was no statistically significant difference between parathyroid hormone levels between cases and controls (2.25 pmol/L and 2.38 pmol/L, respectively). Additionally, though 78% of women were taking at least 10 µg (400 IU) vitamin D daily, 43% had a vitamin D sufficiency (25-hydroxyvitamin D <50 nmol/L). Of note, there were significant differences in background characteristics between cases and control...

2 Minute Medicine Rewind November 16, 2020

...have epidural anesthesia or not during labor 1. A decision aid tool significantly helped resolve decision conflict in patients contemplating the use of epidural anesthesia during labour. Evidence Rating Level: 1 (Excellent) In Japan, analgesic use in delivery of babies is low compared to other countries, with only 6.2% of women receiving epidural anesthesia in 2016. This could stem from a variety of reasons, such as few hospitals where epidurals...

USPSTF Update: Screening adults for unhealthy drug use has moderate net benefit

...lack of standardization of screening methods. Additionally, while a significant number of adolescents ages 12-17 are known to be impacted by drug abuse, the data regarding the benefits and accuracy of screening for this disorder in this population was inconclusive. Further study in this population is warranted. Click to read the study in JAMA Relevant Reading: Screening for Unhealthy Drug Use. Neither an Unreasonable Idea Nor an Evidence-Based Pr...

2 Minute Medicine Rewind August 17, 2020

...ociated mortality. Propensity-score adjusted analysis did not show a significant difference in mortality compared to no exposure however a trend was noted (aHR 0.76, 95% CI 0.57-1.00). Study findings are in keeping with recent literature that have found questionable benefits for the use of hydroxychloroquine for treatment of COVID-19. Likewise, no mortality benefit was found for the use of tocilizumab, though further larger scaled randomized studi...

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