Tag: influenza

1. A total of 10% of pregnant mothers received the influenza vaccination during the study period, but this number grew from 2% to 21% after the H1N1 influenza pandemic. 2. Infants born to influenza-immunized mothers had fewer reported influenza-like events, a smaller amount of laboratory-confirmed episodes of influenza, and fewer...
1. When the two cell types were cultured together, human mesenchymal stromal cells (MSCs) normalized the fluid and protein exchange functions of alveolar epithelial cells. 2. In a mouse model of influenza H5N1 infection, treatment with MSCs led to improved survival and disease pathology. Evidence Rating Level: 2 (Good) Study Rundown: Currently,...
1. Live attenuated influenza vaccine (LAIV), administered intranasally, was less effective in recent seasons at preventing influenza A/H1N1pdm09 among children and adolescents than the intramuscularly-administered inactivated version (IIV). Study Rundown: Though prior studies had supported use of intranasal LAIV, there is little data to compare its effectiveness against the traditional,...
1. The American Academy of Pediatrics (AAP) reaffirms its support for mandatory influenza vaccination for all health care personnel (HCP). 2. The AAP supports nationwide implementation of mandatory vaccination programs in accordance with the 2020 goal of reaching a 90% coverage rate among HCPs. Rundown: Illness from influenza has an annual...
  1. VIS410, a human antibody which targets the hemagglutinin (HA) glycoprotein on the surface of flu viruses, showed strong binding to a variety of influenza A virus strains based on computational and in vitro experiments. 2. Administration of VIS410 either alone or in combination with oseltamivir, a neuraminidase inhibitor,...
1. In the Tennessee county examined, vaccination rates for children age 6 to 59 months began at 6% and reached 38% by the end of 11 flu seasons, during which time flu-related hospitalizations tended to decrease and ED visits tended to increase. 2. Hospitalization rates and ED visits were higher...
1. Seasonal influenza vaccination protected HIV-uninfected and HIV-infected pregnant women against confirmed influenza. 2. In infants from HIV-uninfected mothers, the benefits of this protection extended for up to 24 weeks post-partum. Evidence Rating Level: 1 (Excellent) Study Rundown: During pregnancy, the mother is in an immunocompromised state of health....
In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Urinary Sodium and Potassium Excretion, Mortality, and Cardiovascular Events Decreased sodium intake is associated with a modest decrease in blood pressure, but it is unclear whether this translates to a decrease in...
1. High-dose influenza vaccination significantly reduced the incidence of influenza illness in adults 65 years of age or older when compared with the standard-dose vaccine.  Evidence Rating Level: 1 (Excellent) Study Rundown: Seasonal influenza remains a major cause of morbidity and mortality, particularly amongst individuals 65 years of age or older....
1. Over 1/3 of children presenting to a tertiary emergency department (ED) with influenza-like illness went on to develop severe complications, including respiratory failure, encephalopathy, seizures, pneumonia, bacteremia, and death.  2. Children with underlying neurological or neuromuscular disease were 4 times more likely to develop complications compared to other children. Evidence...