Tag: SARS-CoV-2

1. Children with COVID-19 tended to have milder clinical manifestations, with nearly half of the infected cohort being asymptomatic. 2. Children with COVID-19 had a significantly lower prevalence of cough, fever, pneumonia, and CRP elevation compared to adults. Evidence Rating: 3 (Average) The clinical and characteristics of children affected by COVID-19 are...
1. In this small, uncontrolled, non-randomized case series, clinical improvement was noted in 5 critically ill patients with COVID-19 and ARDS following treatment with convalescent plasma. Evidence Rating: 4 (Below Average) With no specific therapeutic agents or vaccines available for COVID-19, ongoing efforts are being made to identify a treatment option...
1. In-hospital COVID-19-related death was associated with older age, d-dimer levels greater than 1.0μg/mL, and higher Sequential Organ Failure Assessment upon assessment. 2. Median viral shedding in survivors was 20 days but was present until death in fatal cases. 3. Hypertension, diabetes, and coronary artery disease were the most common comorbidities in the...
1. In this randomized controlled trial involving adults hospitalized with confirmed SARS-CoV-2 infection, treatment with lopinavir-ritonavir in addition to standard supportive care did not yield appreciable benefit. 2. No significant difference between groups was observed in mortality, viral RNA loads, or duration of detectability. Evidence Rating Level: 2 (Good) Study Rundown: The...
1. In this study conducted in China, several patients with SARS-CoV-2-negative respiratory samples had sputum and feces that remained positive for several weeks. 2. A number of patients had respiratory samples revert to SARS-CoV-2-positive during hospitalization. This suggested the need for further research regarding the relationship between nucleic acid testing...
1. The American Academy of Pediatrics (AAP) recommends that newborns born to mothers affected by or being tested for COVID-19 be temporarily separated from their mothers. It is also recommended that these infants be separated from newborns born to unaffected mothers in order to reduce risk of transmission. 2. The...
1. Three clusters of COVID-19 were identified that resulted in further transmission beyond household clusters, including a cluster that did not recently travel to China, suggesting a need for strong surveillance strategies to minimize spread of the virus. Evidence Rating Level: 3 (Average) Coronavirus disease 2019 (COVID-19) was first reported in Wuhan,...
1. Study findings suggest that risk factors predisposing patients to progression to acute respiratory distress syndrome (ARDS) include older age, neutrophilia, and organ and coagulation dysfunction. 2. Some factors, including high fever, were associated with higher rates of ARDS development but lower rates of mortality. 3. In this observational study with...
1. In-hospital COVID-19-related death was associated with older age, d-dimer levels greater than 1.0μg/mL, and higher Sequential Organ Failure Assessment upon assessment. 2. Median viral shedding in survivors was 20 days but was present until death in fatal cases. 3. Hypertension, diabetes, and coronary artery disease were the most common comorbidities in the...
1. COVID-19 pneumonia findings on chest computed tomography (CT) are present even in asymptomatic patients. 2. The pattern of findings appear to progress from focal unilateral to diffuse bilateral ground-glass opacities with or without consolidations within 1 to 3 weeks of infection. Evidence Rating: 3 (Average) Although chest CT imaging is one...