Tag: transfusion

In this section, we highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Multidrug-Resistant Tuberculosis and Culture Conversion with Bedaquiline The incidence of tuberculosis in 2012 was estimated at 8.6 million according to the World Health Organization (WHO), and multidrug-resistant tuberculosis remains a challenge worldwide....
1.  In children with sickle cell anemia and silent infarcts, the incidence of recurrent infarcts was significantly lower in the blood transfusion group compared to the observation group.  2. The rates of vaso-occlusive episodes, priapism, acute chest syndrome, and new avascular necrosis of the hip were lower in the transfusion...
1. Patients receiving tranexamic acid during total hip and knee arthroplasty had lower rates of blood transfusion.  2. Tranexamic acid use was associated with a shorter hospital stay and lower hospital cost.  Evidence Rating Level: 2 (Good)        Study Rundown: Perioperative blood loss and blood transfusions after orthopedic surgery are...
Image: PD In this section, we will highlight the key high-impact studies, updates, and analyses published in medicine during the past week. Health Care–Associated Infection After Red Blood Cell Transfusion A Systematic Review and Meta-analysis Direct transmission of infectious agents via RBC transfusion is extremely low in developed countries; however, RBC transfusions trigger...
Image: PD  1. Transfusion protocols employing restrictive transfusion thresholds demonstrate a decreased risk of infection as compared to those employing morel liberal thresholds.  2. Thirty-eight patients need to be treated with a restrictive transfusion protocol in order to prevent one health care-associated infection.  Evidence Rating Level: 1 (Excellent) Study Rundown: One method by...
Image: PD 1. The overall red blood cell transfusion rate among 1,431 US hospitals was 2.14%. 2. Blood transfusions in percutaneous coronary intervention patients was associated with increased risk of in-hospital events such as myocardial infarction, stroke and death. Evidence Rating Level: 2 (Good)  Study Rundown: Patients receive red blood cell transfusions for...
Image: PD 1. High-dose prophylaxis for severe hemophilia increases total cost of care.  2. Compared to intermediate-doses, high-dose prophylaxis reduces bleeding and hemophilic arthropathy, but results in equal quality of life.  Evidence Rating Level: 2 (Good) Study Rundown: Though relatively rare, patients with severe hemophilia are at risk for spontaneous and trauma-related bleeding leading to...
Classics Series, Landmark Trials in Medicine
1. Using a restrictive transfusion strategy in critically ill patients did not significantly increase 30-day mortality when compared with a liberal transfusion strategy. 2. Subgroup analyses demonstrated that a restrictive transfusion strategy was associated with significantly lower mortality in patients with APACHE II score ≤20 and age <55 years. Original Date...