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2 Minute MedicineICD-10 Lookup

ICD-10-CM code · FY2027

T43.21 Poisoning by, adverse effect of and underdosing of selective serotonin and norepinephrine reuptake inhibitors

Header codeNot billable: use one of the 18 billable codes below

About T43.21

Code
T43.21
Billable
No, header
Short description
Selective serotonin and norepinephrine reuptake inhibitors
Category
T43 Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified
Block
T36-T50 Poisoning by, adverse effects of and underdosing of drugs, medicaments and biological substances
Chapter
19 Injury, poisoning and certain other consequences of external causes
Code set
FY2027, October 1, 2026 to September 30, 2027

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Coding notes for T43.21

Applicable to Other names for conditions reported with this code.

  • Poisoning by, adverse effect of and underdosing of SSNRI antidepressants

7th character Required: add one of these as the 7th character, with X as a placeholder to fill six characters.

CharacterMeaning
Ainitial encounter
Dsubsequent encounter
Ssequela

Also applies, from T43 Poisoning by, adverse effect of and underdosing of psychotropic drugs, not elsewhere classified

Excludes2 Not part of this condition, but a patient can have both: report both codes when both apply.

  • appetite depressants (T50.5-)
  • barbiturates (T42.3-)
  • benzodiazepines (T42.4-)
  • drug dependence and related mental and behavioral disorders due to psychoactive substance use (F10.- -F19.-)
  • methaqualone (T42.6-)
  • psychodysleptics [hallucinogens] (T40.7-T40.9-)

7th character

  • The appropriate 7th character is to be added to each code from category T43
Block T36-T50 notes (apply to every code in it)

Includes Conditions this code covers.

  • adverse effect of correct substance properly administered
  • poisoning by overdose of substance
  • poisoning by wrong substance given or taken in error
  • underdosing by (inadvertently) (deliberately) taking less substance than prescribed or instructed

Note

  • The drug giving rise to the adverse effect should be identified by use of codes from categories T36-T50 with fifth or sixth character 5.

Excludes1 Not coded here: never report these together with this code (use the code given instead).

  • toxic reaction to local anesthesia in pregnancy (O29.3-)

Excludes2 Not part of this condition, but a patient can have both: report both codes when both apply.

  • abuse and dependence of psychoactive substances (F10-F19)
  • abuse of non-dependence-producing substances (F55.-)
  • immunodeficiency due to drugs (D84.821)
  • drug reaction and poisoning affecting newborn (P00-P96)
  • pathological drug intoxication (inebriation) (F10-F19)

Code first Report the underlying condition's code before this one.

  • , for adverse effects, the nature of the adverse effect, such as:
  • adverse effect NOS (T88.7)
  • aspirin gastritis (K29.-)
  • blood disorders (D56-D76)
  • contact dermatitis (L23-L25)
  • dermatitis due to substances taken internally (L27.-)
  • nephropathy (N14.0-N14.2)

Use additional code Add a second code for the detail named here.

  • code(s) to specify:
  • manifestations of poisoning
  • underdosing or failure in dosage during medical and surgical care (Y63.6, Y63.8-Y63.9)
  • underdosing of medication regimen (Z91.12-, Z91.13-)
Chapter 19 notes (apply to every code in it)

Note

  • Use secondary code(s) from Chapter 20, External causes of morbidity, to indicate cause of injury. Codes within the T section that include the external cause do not require an additional external cause code
  • The chapter uses the S-section for coding different types of injuries related to single body regions and the T-section to cover injuries to unspecified body regions as well as poisoning and certain other consequences of external causes.

Excludes2 Not part of this condition, but a patient can have both: report both codes when both apply.

Use additional code Add a second code for the detail named here.

  • code to identify any retained foreign body, if applicable (Z18.-)

Codes under T43.21 24

Related codes in T43.2

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