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Delayed initiation of antibiotic therapy is associated with worse outcomes in skin and soft tissue infections
1. Delayed initiation of antibiotic therapy was strongly associated with treatment failure and prolonged hospitalization in hospitalized SSTI patients. 2. Comorbidity burden and socioeconomic disparities significantly influenced SSTI outcomes, highlighting...
Caloric restriction and intermittent fasting show mixed human longevity data
Caloric restriction and intermittent fasting show mixed human longevity data Caloric restriction remains one of the most robust interventions for extending lifespan in animal models, with consistent improvements observed across...
Selective serotonin reuptake inhibitors may reduce risk of total joint arthroplasty in osteoarthritis
1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total joint arthroplasty compared with SSRI initiation. 2. Management of comorbid...
Physical frailty is associated with increased risk of epilepsy
1. Physical frailty, particularly slow gait speed, was independently associated with a significantly increased risk of incident epilepsy in a large longitudinal cohort. Evidence Rating Level: 2 (Good) In this...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
