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2 Minute Medicine Rewind August 10, 2026
Melatonin Use and Polysomnographic Sleep Architecture in Children 1. In an observational study of pediatric patients, melatonin use may be associated with a decreased percentage of rapid eye movement (REM)...
Perioperative toripalimab improves event-free survival in non-small cell lung cancer
1. In patients with resectable stage III non-small cell lung cancer, perioperative toripalimab plus chemotherapy increased rates of tumor and lymph node downstaging and improved event-free survival compared to chemotherapy...
Antithrombotic agents may be effective in preventing migraine in patients with patent foramen ovale
1. The antithrombotic agents aspirin, clopidogrel, and rivaroxaban were non-inferior to metoprolol for responder rate in participants with patent foramen ovale and migraine. Evidence Rating Level: 1 (Excellent) Patent foramen...
Active surveillance is cost-effective compared with standard surgery among esophageal cancer patients with complete clinical response after neoadjuvant chemoradiotherapy
1. Active surveillance was cost-effective over 5 years compared with standard surgery in patients with esophageal cancer and complete clinical response after neoadjuvant chemoradiotherapy. Evidence Rating Level: 1 (Excellent) Active...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
