Higher parental vitamin B12 associated with fewer birth defects
1. In this prospective cohort study, higher parental preconception and maternal postconception vitamin B12 levels were associated with lower odds and prevalence of birth defects. 2. Higher folate levels were...
Newer GLP-1 agents yield substantial weight loss in nondiabetic adults
1. In this updated systematic review, glucagon-like peptide-1 receptor agonists and co-agonists produced substantial weight loss in adults without diabetes, with greater reductions observed with newer agents. 2. Newer agents...
2 Minute Medicine Rewind August 31, 2026
Periprocedural Mortality Risk After Elective Atrial Fibrillation Ablation in Japan 1. The in-hospital mortality rate among patients undergoing elective catheter ablation for atrial fibrillation was low at approximately 0.029%. Evidence...
Dementia diagnosis underreporting is common and associated with reduced care engagement
1. In this retrospective cohort study involving older adults with probable dementia and a claims-based diagnosis, underreporting of dementia was substantially more common than underreporting of other diagnosed chronic conditions. ...
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Explore the Classics Series™
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
ABCD2 Score: Predicting Early Stroke Risk After Transient Ischemic Attack (TIA) [Classics Series]
1. The ABCD2 score is a validated clinical tool that estimates the short-term risk of stroke following a transient...
Child-Pugh Score: Prognosis, Classification & Cirrhosis Staging in Chronic Liver Disease [Classics Series]
1. The Child-Pugh score, derived from five clinical and lab measures (bilirubin, albumin, INR/prothrombin time, ascites, encephalopathy), is widely...
POISE Trial: Perioperative Metoprolol Reduces MI but Increases Stroke & Mortality [Classics Series]
1. In adults undergoing noncardiac surgery, perioperative β-blocker therapy with extended-release metoprolol significantly reduced nonfatal myocardial infarction (MI) risk...
