Enzalutamide (Xtandi) and abiraterone (Zytiga) may have similar effectiveness in metastatic castration-sensitive prostate cancer
1. The use of enzalutamide (Xtandi) and abiraterone (Zytiga) in metastatic castration-sensitive prostate cancer (mCSPC) was associated with similar overall survival (OS). 2. The use of enzalutamide was associated with...
Intermittent metformin (Glucophage) is non-inferior to continuous metformin for prediabetes in post-partum women with prior gestational diabetes mellitus
1. Among women with prediabetes following prior gestational diabetes mellitus (GDM), intermittent metformin (Glucophage) in combination with lifestyle modifications was non-inferior to continuous metformin in combination with lifestyle modifications. Evidence...
NHS rolls out Microsoft Copilot to 505,000 clinicians
1. ARPA-H selected innovation teams in June 2026 for the ADVOCATE program, a three-year federally funded effort to build the first FDA-authorized autonomous AI agent capable of providing around-the-clock specialty...
Novel antifungal shows promise for patients with refractory disseminated coccidioidomycosis
1. In this single-group, open-label trial, olorofim was associated with a complete or partial clinical response in over 75% of patients with disseminated coccidioidomycosis (DCM) and limited or no treatment...
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
