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Duloxetine is effective in refractory chronic cough
1. Duloxetine is significantly more effective than placebo at reducing refractory chronic cough (RCC) frequency and sensitivity. Evidence Rating Level: 1 (Excellent) 20%-46% of patients with chronic cough, defined as...
AstraZeneca moves to own multimodal oncology AI with Modella
1. AstraZeneca is acquiring Modella AI to embed multimodal foundation models into oncology R&D and strengthen biomarker driven trial strategy. 2. The practical payoff for clinicians would be cleaner cohort...
Cast immobilization is non-inferior to surgical intervention in isolated Weber B fractures of lateral malleolus
1. Cast immobilization is non-inferior to surgical treatment with open reduction and internal plate fixation (ORIF) in the management of isolated Weber B fractures of the lateral malleolus with a...
NVIDIA and Lilly put $1B behind AI as core drug infrastructure
1. NVIDIA and Eli Lilly plan to invest up to $1B over five years in a joint AI lab to tighten the loop between model building and wet lab validation....
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Explore the Classics Series™
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
