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A multimodal approach combining cognitive assessment with biomarkers may accurately predict dementia risk
1. Plasma p-tau217 was the strongest individual biomarker for predicting progression to Alzheimer's disease dementia in patients with subjective cognitive decline. 2. A multimodal model combining cognitive assessment, plasma p-tau217,...
Sentinel lymph node biopsy may reduce the need for axillary dissection in cN1 breast cancer
1. Upfront sentinel lymph node biopsy permitted the avoidance of axillary lymph node dissection in most patients with cN1 HR+/HER2- breast cancer and limited ultrasound findings. 2. Sentinel lymph node...
Metformin remains a leading candidate for pharmacologic longevity intervention
Metformin remains a leading candidate for pharmacologic longevity intervention Metformin continues to occupy a unique position in longevity medicine because of its long track record and well understood safety profile....
An intradialytic exercise intervention did not improve dialysis adequacy
1. A 4-week intradialytic pedalling exercise program was safe and well-tolerated but did not significantly improve dialysis adequacy measures. Evidence Rating Level: 1 (Excellent) This randomized controlled trial evaluated whether...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
