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A chemical denervation intervention may be safe and effective for pain management in avascular necrosis of the hip
1. Chemical neurolysis of the anterior hip capsular branches appears to be a safe and effective analgesic option for AVN-related hip pain refractory to conservative management, with durable benefit in...
Chemotherapy exposure is independently associated with reduced pain severity in advanced pancreatic cancer
1. Chemotherapy appears to be independently associated with reduced pain severity in advanced pancreatic cancer, reinforcing the importance of routine, longitudinal pain assessment and proactive, individualized symptom management from diagnosis...
Foundayo (Orforglipron) Approval Marks the Beginning of the Oral GLP-1 Era for Obesity Treatment
1. The FDA approved orforglipron (Foundayo) on April 1, 2026, making it the first non-peptide oral GLP-1 receptor agonist cleared for obesity treatment and the first oral GLP-1 pill with...
Spinal instability may be the primary cause of pain in sacral metastases as opposed to neurologic compromise
1. Although neurological symptoms (motor deficits, sensory impairment) were more frequent in patients with sitting-related sacral pain on univariate comparison, this association did not hold in multivariable analysis (aOR 0.83,...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
