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Wide awake local anesthesia no tourniquet (WALANT) versus ultrasound-guided axillary block in carpal tunnel release: a non-inferiority randomized controlled trial
1. For outpatient endoscopic carpal tunnel release, wide-awake local anesthesia without a tourniquet achieves at least the same anesthetic success as an ultrasound-guided axillary brachial plexus block while better preserving...
2 Minute Medicine Rewind November 17, 2025
Vernakalant versus procainamide for rapid cardioversion of patients with acute atrial fibrillation (RAFF4): randomised clinical trial 1. Vernakalant was superior to procainamide for rapid cardioversion of patients with acute atrial...
Diphenhydramine, Sodium Bicarbonate, or Combination for Acute Peripheral Vertigo: A Randomized Clinical Trial
1. In this randomized clinical trial, combination therapy with diphenhydramine and sodium bicarbonate was associated with decreased vertigo compared to therapy with diphenhydramine alone. Evidence Rating Level: 1 (Excellent) Vertigo...
Risk of Parkinson’s disease after human papillomavirus infection: a nationwide cohort study
1. In this cohort, Human papillomavirus (HPV) infection was associated with increased risk of developing Parkinson’s disease (PD), specifically in men. Evidence Rating Level: 2 (Good) Parkinson’s disease (PD) is...
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Explore the Classics Series™
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
