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Adjuvanted influenza vaccines and high-dose influenza vaccines may have similar effectiveness in adult patients
1. Adjuvanted influenza vaccines did not differ significantly in effectiveness compared to high-dose influenza vaccines against laboratory-confirmed influenza and influenza-related hospitalizations or emergency department (ED) visits in adult patients. Evidence...
Ambient artificial intelligence scribes reduce clinician documentation time by 16 minutes per encounter
Ambient artificial intelligence scribes reduce clinician documentation time by 16 minutes per encounter A large study published in JAMA in April 2026 provides strong evidence that ambient artificial intelligence scribes...
Resuscitative endovascular balloon occlusion of the aorta may not improve outcomes in adults with non-traumatic out-of-hospital cardiac arrest
1. Resuscitative endovascular balloon occlusion of the aorta (REBOA) as an adjunct to advanced life support (ALS) does not improve rates of return of spontaneous circulation (ROSC) in adult patients...
Use of selective serotonin reuptake inhibitors guided by pharmacogenetic testing may improve treatment response in depression
1. Genotype-guided prescribing of selective serotonin reuptake inhibitors (SSRIs) may improve treatment response in children and adults with depression. Evidence Rating Level: 1 (Excellent) Although SSRIs are the most prescribed...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
