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Pfizer’s Talzenna combo significantly delays prostate cancer progression
1. The combination of talazoparib and enzalutamide demonstrated a statistically significant improvement in radiographic progression-free survival for metastatic hormone-sensitive prostate cancer. 2. These results from the TALAPRO-3 trial suggest that...
Bottom-vented bottles may not reduce gastrointestinal discomfort in infants
1. In this randomized controlled trial, bottom‑vented bottles did not reduce mild gastrointestinal discomfort overall in infants aged 0–90 days. Evidence Rating Level: 1 (Excellent) Bottle feeding infants in the...
Ketorolac administration after cesarean delivery may reduce postoperative opioid use
1. In this randomized controlled trial, a 60‑mg IV ketorolac loading dose after cesarean delivery modestly reduced postoperative opioid use and delayed the need for first opioid administration compared with...
One Big Beautiful Bill could impact half of Medicaid beneficiaries
1. In this cross-sectional study, about half of Medicaid beneficiaries would lose coverage if work requirements in the One Big Beautiful Bill were applied nationwide. 2. Beneficiaries at risk of...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
