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The addition of leflunomide (Arava) to prednisone (Deltasone) may not improve rate of remission in Takayasu arteritis
1. Leflunomide (LEF) plus prednisone was well tolerated but did not significantly increase clinical remission of Takayasu arteritis (TAK) compared to placebo plus prednisone. Evidence Rating Level: 1 (Excellent) TAK...
Perioperative vitamin C supplementation may not reduce bleeding in percutaneous renal biopsy patients
1. Administration of perioperative intravenous vitamin C for percutaneous renal biopsy may not reduce the rate of bleeding complications. Evidence Rating Level: 1 (Excellent) PRB is an essential procedure for...
Glucosamine Linked to Faster Alzheimer’s Progression in Patients with Mild Cognitive Impairment
1. University of Florida researchers found that glucosamine, the popular joint supplement taken by tens of millions of older Americans, is associated with a 25% higher likelihood of progressing from...
Enfortumab vedotin plus pembrolizumab is more effective than platinum-based chemotherapy in metastatic urothelial carcinoma
1. In the management of adult patients with metastatic urothelial carcinoma (MUC), enfortumab vedotin plus pembrolizumab (EV/P) was well-tolerated and significantly more effective than gemcitabine plus cisplatin (G/C). Evidence Rating...
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Explore the Classics Series™
EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
Ablation may reduce stroke risk, death, heart failure hospitalization in patients with atrial fibrillation
1. In this systematic review and meta-analysis, catheter ablation was found to reduce overall risk of ischemic stroke, hospitalization...
Breast cancer survivors may have a lower risk of Alzheimer’s dementia
1. In this retrospective cohort study, breast cancer survivors had a lower risk of Alzheimer’s dementia compared with cancer-free...
Repeated medial branch blocks do not improve pain outcomes for thermal radiofrequency ablation
1. For patients with facet-mediated spine pain that achieve ≥80% pain relief after a medial branch block, a second...
