In selected patients with anterior-circulation large-vessel stroke 24-72 hours after onset, thrombectomy improved 90-day function but increased hemorrhage and death
1. Results from a large, open-label, multi-site study in China suggest there is benefit for long-term functional outcome, lower rates of disability for mechanical thrombectomy in patients 24 to 72...
Mavacamten reduced left ventricular outflow tract obstruction more than placebo in adolescents with symptomatic obstructive hypertrophic cardiomyopathy
In a phase 3 trial, mavacamten reduced left ventricular outflow tract obstruction more than placebo in adolescents with symptomatic obstructive hypertrophic cardiomyopathy.
Zavegepant (Zavzpret) may be effective for the management of migraine symptoms in Asian adults
1. Zavegepant (Zavzpret), a calcitonin gene-related peptide receptor antagonist (CGRPRA), is well-tolerated and significantly improves resolution of migraine symptoms in Asian adults with migraines.
Routine postdilation improves transcatheter heart valve geometry in patients with severe aortic stenosis
1. In this randomized clinical trial of patients with aortic stenosis (AS),routine postdilation yielded a significantly lower transcatheter heart valve (THV) asymmetry index compared with no postdilation, consistent across prespecified...
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
BI-RADS study identifies mammography features with high positive predictive values for carcinoma [Classics Series]
1. Lesions observed in mammography with spiculated margins, linear calcification morphology, irregular shape, segmental calcification distribution, or linear calcification...
Thrombectomy between 6 and 24 hours after acute stroke reduces disability: The DAWN trial [Classics Series]
1. Thrombectomy performed between 6 and 24 hours after onset of acute stroke in patients with a mismatch between...
Ottawa ankle rules reduce the rate of referral for ankle radiography [Classics Series]
1. The Ottawa ankle rules significantly reduced referral for ankle, but not foot, radiography in the emergency department. 2....
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