Care recommendations by large language models were associated with higher healthcare costs
1. Across 200 cases, large language models (LLMs) recommended diagnostic tests and referrals that were associated with 3.2 times the cost compared to physician plans. 2. Prompts that accounted for...
FDA approves dostarlimab (Jemperli) for certain patients with locally advanced rectal cancer
1. Interim results from the phase 2 AZUR-1 trial have demonstrated that at a median follow-up of 2 years. nearly 75% of patients did not require surgery, radiotherapy, or chemotherapy...
In topline phase 3 results, retatrutide lowered A1C more and reduced weight more than semaglutide 2 mg at 80 weeks
In topline phase 3 results, retatrutide lowered A1C and body weight more than semaglutide 2 mg in adults with type 2 diabetes at 80 weeks.
Sacituzumab tirumotecan improved progression-free and overall survival versus chemotherapy in previously treated endometrial cancer
In a randomized phase 3 trial, sacituzumab tirumotecan improved progression-free and overall survival versus physician’s-choice chemotherapy in previously treated endometrial cancer.
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
BI-RADS study identifies mammography features with high positive predictive values for carcinoma [Classics Series]
1. Lesions observed in mammography with spiculated margins, linear calcification morphology, irregular shape, segmental calcification distribution, or linear calcification...
Thrombectomy between 6 and 24 hours after acute stroke reduces disability: The DAWN trial [Classics Series]
1. Thrombectomy performed between 6 and 24 hours after onset of acute stroke in patients with a mismatch between...
Ottawa ankle rules reduce the rate of referral for ankle radiography [Classics Series]
1. The Ottawa ankle rules significantly reduced referral for ankle, but not foot, radiography in the emergency department. 2....
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