An artificial intelligence system for human papillomavirus-positive dual stain cervical cancer screening reads p16-Ki67 slides
1. Lahrmann and colleagues developed an artificial intelligence (AI) system using dual stain triage for HPV-based cervical cancer screening to retrospectively analyze 9006 slides across 4 cohorts. 2. Results indicated...
Elevated low-density lipoprotein cholesterol is a risk factor for atherosclerotic disease irrespective of familial hypercholesterolemia status
1. In a large registry-based cohort study, patients who underwent genetic testing for familial hypercholesterolemia between 1991 and 2023 were examined for cardiovascular outcomes and compared to those with negative...
A community health initiative in low-income areas may reduce hospital admission rates
1. In this longitudinal cross-sectional RCT, 30 low-income apartment buildings in Ontario received visits from the community paramedicine clinic, resulting in significantly lower hospital admission rates and an increase in...
Induction with remimazolam (Byfavo) for patients undergoing laparoscopic gastrointestinal surgery may reduce post-operative delirium compared with propofol
1. In this randomized controlled trial, elderly patients who received remimazolam (Byfavo) prior to undergoing elective laparoscopic gastrointestinal surgery had reduced post-operative delirium compared with those induced with propofol.
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EAST-AFNET 4 Trial: Early Rhythm Control vs Usual Care in Atrial Fibrillation (East AF) [Classics Series]
1. The EAST-AFNET 4 trial (East AF) demonstrated that early rhythm control therapy—including antiarrhythmic drugs or catheter ablation—was associated...
BI-RADS study identifies mammography features with high positive predictive values for carcinoma [Classics Series]
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Ottawa ankle rules reduce the rate of referral for ankle radiography [Classics Series]
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Canadian C-Spine Rules superior to NEXUS Low-Risk Criteria for detecting cervical-spine injuries [Classics Series]
1. The Canadian C-Spine Rule (CCR, Figure I) demonstrated higher sensitivity and specificity for cervical-spine injury compared to the...
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