A Comparison of Psoriasis Severity in Pediatric Patients Treated With Methotrexate vs Biologic Agents

1. Treatment with biologics in pediatric patients with moderate to severe psoriasis was significantly associated with greater reduction in psoriasis severity than methotrexate, though...

Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma...

1. Immune-related adverse events are associated with a longer recurrence-free survival in patients with stage III melanoma treated with pembrolizumab. Evidence Rating Level: 1 (Excellent) Immune-related adverse...

Difelikefalin associated with reductions in itch intensity and improvements in itch-related quality of life

1. In this double-blind phase 3 trial involving patients undergoing hemodialysis who had moderate-to-severe pruritus, a clinically significant decrease in itching intensity was noted...

Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis: The ADAPT Randomized Clinical Trial

1. In treatment-resistant childhood atopic dermatitis, omalizumab significantly reduced the severity of dermatitis and improved quality of life compared to placebo.  Evidence Rating Level: 1...

The CLASS trial: laser ablation and surgery improve quality-of-life for varicose vein patients compared...

1. In patients with primary varicose veins followed for 5 years after treatment, those randomized to receive laser ablation or surgery reported greater improvements...

Quick Take: 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than...

The ideal surgical excision margin for patients with thick (>2 mm) localized cutaneous melanomas is unclear, where the risk of recurrence must be weighed...

Quick Take: Risankizumab compared with adalimumab in patients with moderate-to-severe plaque psoriasis (IMMvent)

In this randomized controlled trial, 605 patients with moderate-to-severe chronic plaque psoriasis were assigned to receive 150 mg risankizumab subcutaneously at weeks 0 and...

Quick Take: Treatment Outcomes of Immune-Related Cutaneous Adverse Events

Immune-checkpoint inhibitors (ICIs) have significantly improved outcomes in a variety of malignancies. Immune-related adverse events, however, are common and may lead to treatment discontinuation...

Sodium-glucose cotransporter-2 inhibitors may be linked to Fournier gangrene

1. In this descriptive case series, 55 cases of patients with diabetes who developed Fournier gangrene while using sodium-glucose cotransporter-2 (SGLT2) inhibitors are described. 2....

Quick Take: Pulsed Dye Laser Treatment of Port-Wine Stains in Infancy Without the Need...

There is currently controversy surrounding the use of laser treatment for port-wine stains (PWS) in children, with specific concerns around the repetitive use of...
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