Difelikefalin associated with reductions in itch intensity and improvements in itch-related quality of life

1. In this double-blind phase 3 trial involving patients undergoing hemodialysis who had moderate-to-severe pruritus, a clinically significant decrease in itching intensity was noted...

Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis: The ADAPT Randomized Clinical Trial

1. In treatment-resistant childhood atopic dermatitis, omalizumab significantly reduced the severity of dermatitis and improved quality of life compared to placebo. Evidence Rating Level: 1...

The CLASS trial: laser ablation and surgery improve quality-of-life for varicose vein patients compared...

1. In patients with primary varicose veins followed for 5 years after treatment, those randomized to receive laser ablation or surgery reported greater improvements...

Quick Take: 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than...

The ideal surgical excision margin for patients with thick (>2 mm) localized cutaneous melanomas is unclear, where the risk of recurrence must be weighed...

Quick Take: Risankizumab compared with adalimumab in patients with moderate-to-severe plaque psoriasis (IMMvent)

In this randomized controlled trial, 605 patients with moderate-to-severe chronic plaque psoriasis were assigned to receive 150 mg risankizumab subcutaneously at weeks 0 and...

Quick Take: Treatment Outcomes of Immune-Related Cutaneous Adverse Events

Immune-checkpoint inhibitors (ICIs) have significantly improved outcomes in a variety of malignancies. Immune-related adverse events, however, are common and may lead to treatment discontinuation...

Sodium-glucose cotransporter-2 inhibitors may be linked to Fournier gangrene

1. In this descriptive case series, 55 cases of patients with diabetes who developed Fournier gangrene while using sodium-glucose cotransporter-2 (SGLT2) inhibitors are described.2....

Quick Take: Pulsed Dye Laser Treatment of Port-Wine Stains in Infancy Without the Need...

There is currently controversy surrounding the use of laser treatment for port-wine stains (PWS) in children, with specific concerns around the repetitive use of...

Melanoma as a possible cause of autoimmune encephalitis

1. A woman developed anti-AMPA receptor encephalitis in the setting of metastatic melanoma.2. Following a short delay, she responded well to vemurafenib and cobimetinib....

Quick Take: Association of Atopic Dermatitis With Sleep Quality in Children

Atopic dermatitis, a common disorder in the pediatric population, is associated with pruritus that is often worse at night and, thus, can interfere with...
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