Ultrasound effective for identifying in-transit metastases in patients with cutaneous melanoma

1. Among patients with cutaneous melanoma, ultrasound evaluation identified in half of patients in-transit metastases that were otherwise not apparent during clinical examination and...

Roflumilast effective for treatment of chronic plaque psoriasis

1. A significantly greater percentage of both roflumilast groups had clear or nearly clear skin compared to the control group after 6 weeks of...

Nemolizumab effective in reducing pruritis in atopic dermatitis

1. In this study, nemolizumab with topical agents and oral antihistamines when compared to topical agents and oral antihistamines alone reduced pruritis in atopic...

Mycophenolate an effective option for morphea treatment

1. In patients with different types of morphea unresponsive to phototherapy and methotrexate, mycophenolate appears to be a safe and beneficial treatment option. Evidence Rating:...

A Comparison of Psoriasis Severity in Pediatric Patients Treated With Methotrexate vs Biologic Agents

1. Treatment with biologics in pediatric patients with moderate to severe psoriasis was significantly associated with greater reduction in psoriasis severity than methotrexate, though...

Association Between Immune-Related Adverse Events and Recurrence-Free Survival Among Patients With Stage III Melanoma...

1. Immune-related adverse events are associated with a longer recurrence-free survival in patients with stage III melanoma treated with pembrolizumab. Evidence Rating Level: 1 (Excellent) Immune-related adverse...

Difelikefalin associated with reductions in itch intensity and improvements in itch-related quality of life

1. In this double-blind phase 3 trial involving patients undergoing hemodialysis who had moderate-to-severe pruritus, a clinically significant decrease in itching intensity was noted...

Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis: The ADAPT Randomized Clinical Trial

1. In treatment-resistant childhood atopic dermatitis, omalizumab significantly reduced the severity of dermatitis and improved quality of life compared to placebo.  Evidence Rating Level: 1...

The CLASS trial: laser ablation and surgery improve quality-of-life for varicose vein patients compared...

1. In patients with primary varicose veins followed for 5 years after treatment, those randomized to receive laser ablation or surgery reported greater improvements...

Quick Take: 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than...

The ideal surgical excision margin for patients with thick (>2 mm) localized cutaneous melanomas is unclear, where the risk of recurrence must be weighed...
licensing as small

All-time hits