Pediatrics

Reports of high-impact pediatrics studies by medical professionals

Recombinant viral vector treatment sustains endogenous factor IX activity in patients with hemophilia B

1. A one-time infusion of a recombinant viral vector with a highly expressed factor IX gene resulted in sustained endogenous factor IX coagulant activity...

DNA sequencing may inform diagnosis and management of kidney disease

1. Whole exome sequencing (WES) provided diagnosis for a subset of patients with chronic kidney disease (CKD). 2. Identification of certain mutations, via WES, changed...

Long-term comorbidities in extremely preterm infants with cerebral palsy

1. The lifetime prevalence of cerebral palsy (CP) was estimated to be 10.5% for infants born extremely premature (EP, <27 weeks gestational age), with...

Clinician denial of certain patient requests linked with decreased satisfaction

1. In an observational study of a single family practice clinic, clinician-patient interactions in which a request was denied was linked to lower patient...

Multiple treatment trajectories exist in adolescent depression

1. In this longitudinal retrospective cohort study, there were multiple treatment trajectories identified among youth with depression. 2. Psychotherapy monotherapy was associated with the lowest...

Parents report greater optimism than oncologists about their child’s cancer prognosis

1. Three quarters of parents of children with a cancer diagnosis report greater optimism about their child’s prognosis than the child’s physician. 2. Parents who...

Extremely premature children have worse cognitive outcomes

1. Extremely premature (EP) and extremely low birth weight (ELBW) infants born in the early 2000s have worse executive function outcomes when compared to...

Evidence-based supportive therapy for bronchiolitis varies significantly between hospitals

1. Less than 75% of study infants hospitalized with acute bronchiolitis received the current recommended treatment, evidence-based supportive therapies (EBST), with significant variation between...

Tezacaftor-ivacaftor improves pulmonary function in cystic fibrosis patients: The EVOLVE trial

1. Tezacaftor-Ivacaftor significantly improves lung function and reduces the frequency of pulmonary exacerbations in cystic fibrosis (CF) patients homozygous for the Phe508 deletion (Phe508del). 2....

Gardasil vaccine demonstrates immunogenic response at 10-year follow-up

1. A 3-dose regimen of 4-valent human papillomavirus (4vHPV) vaccine administered between the ages of 9-15 years of age was shown to be immunogenic, clinically...
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