Comparison of Cardiovascular and Safety Outcomes of Chlorthalidone vs Hydrochlorothiazide to Treat Hypertension
1. While chlorthalidone is the recommended thiazide diuretic treatment for hypertension, it has no added benefits compared to hydrochlorothiazide and has significantly worse safety...
Difelikefalin associated with reductions in itch intensity and improvements in itch-related quality of life
1. In this double-blind phase 3 trial involving patients undergoing hemodialysis who had moderate-to-severe pruritus, a clinically significant decrease in itching intensity was noted...
Low risk of nephrogenic systemic fibrosis with group II gadolinium contrast agents in chronic...
1. In a systematic review and meta-analysis of the use of group II (low risk) gadolinium-based contrast agents (GBCA) for MRI in patients with...
Polypill effective for blood pressure and cholesterol control in vulnerable population
1. In this randomized, controlled trial, patients without cardiovascular disease randomized to receive a polypill containing atorvastatin, amlodipine, losartan, and hydrochlorothiazide experienced greater reductions...
Downward trend in mortality rate for antineutrophil cytoplasmic autoantibody-associated vasculitis
1. In this study of decedents from 1999 to 2017, mortality due to antineutrophil cytoplasmic autoantibody-associated vasculitis (AAV) -related illness was found to have...
Quick Take: Patiromer versus placebo to enable spironolactone use in patients with resistant hypertension...
1. Potassium binder therapy with patiromer can promote longer duration of spironolactone use for resistant hypertension in the setting of chronic kidney disease.
Evidence Rating...
Quick Take: Risk of rhabdomyolysis with donepezil compared with rivastigmine or galantamine
1. Donepezil is associated with an elevated short-term risk of hospital admission for rhabdomyolysis compared to rivastigmine or galantamine for Alzheimer’s disease and dementia.
Evidence...
Multidisciplinary approach linked with increased utilization of peritoneal dialysis for new dialysis patients
1. In this retrospective quality improvement cohort study from the United States, a multidisciplinary approach was linked with increased rates of peritoneal dialysis initiation...
Quick Take: HbA1c level as a risk factor for retinopathy and nephropathy in children...
Intensive glycemic control has been shown to reduce the risk of retinopathy and nephropathy in the setting of type 1 diabetes. While prior studies...
Quick Take: Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe...
Hypertension commonly affects women in pregnancy, and is associated with adverse effects for both mother and baby. Currently, there is a lack of consensus...
