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Uric acid-lowering therapy not associated with improved kidney function
1. This retrospective cohort study demonstrated an increased risk of developing an estimated glomerular filtration rate (eGFR) less than 60...
Nephrology
Reports of high-impact nephrology studies by medical professionals
Perioperative dexmedetomidine decreases the incidence of select complications following kidney transplantation
1. This randomized controlled trial found that giving dexmedetomidine for 24 hours at the time of kidney transplant receipt reduced...
Prognostic value demonstrated for change of circulating tumour cells and human leukocyte antigen I: programmed cell death-ligand 1 ratio in metastatic renal cell carcinoma
1. Reduced median overall survival associated with annual rate of change in circulating tumour cell (CTC) abundance >0.12 CTCs/mL 2....
Oral methylprednisolone may reduce risk of progressive renal failure in patients with IgA nephropathy: TESTING Trial
1. This randomized controlled trial found that high dose methylprednisolone for 6-9 months reduced rates of significantly declining kidney function,...
Time restricted eating not more beneficial than daily calorie restriction
1. For patients with obesity, time-restricted eating was not more significantly beneficial in reducing body weight or body fat than...
Lenvatinib plus pembrolizumab show similar health-related quality-of-life outcomes in patients with advanced renal cell carcinoma compared to sunitinib
1. The median follow-up period for health-related quality-of-life (HRQOL) outcomes analyses was 12.9 months 2. For all FKSI-DRS, EORTC QLQ-C30...
Oral tacrolimus noninferior to intravenous cyclophosphamide for lupus nephritis
1. Oral tacrolimus was noninferior to intravenous cyclophosphamide for lupus nephritis disease measures with lower toxicity. Evidence Rating Level: 1...
Cabozantinib may be a viable first-line treatment in metastatic renal cell collecting duct carcinoma
1. Objective response rate was 35%, with 1 patient showing a complete response and 7 showing a partial response. 2....
Improved mortality rates for myocardial infarction, stroke, and pulmonary embolism in patients receiving dialysis between 1998 to 2015
1. Between 1998 to 2015, mortality rates for myocardial infarction, stroke, and pulmonary embolism decreased more in patients receiving dialysis...
Radiofrequency renal denervation produces long-lasting reductions in blood pressure
1. The intervention group saw a 10 mmHg greater reduction in 24-h mean systolic blood pressure compared to the sham...
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