Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease
1. In a meta-analysis of randomized trials evaluating blood pressure control in patients with stage 3-5 chronic kidney disease (CKD), more intensive blood pressure...
Cardiovascular benefits of intensive systolic blood pressure control may outweigh risks of chronic kidney...
1. The benefits of intensive systolic blood pressure (SBP) control to cardiovascular and all-cause mortality may outweigh the increased risk of incident chronic kidney...
Risk of cardiovascular events similar between degludec and glargine in type 2 diabetics: The...
1. Type 2 diabetic patients at high-risk for cardiovascular events treated with the ultra long-acting insulin degludec experienced cardiovascular events at an incidence noninferior...
Canagliflozin reduces cardiovascular outcomes in patients with diabetes: The CANVAS
1. Canagliflozin, a sodium glucose cotransporter 2 (SGLT2) inhibitor, significantly reduced the risk of the primary composite outcome of cardiovascular death, nonfatal myocardial infarction,...
Low-dose aspirin reduces incidence of preterm preeclampsia in high-risk pregnancies: The ASPRE trial
1. Low-dose aspirin significantly reduced the incidence of preterm preeclampsia in women identified as high-risk for preeclampsia using a screening protocol that combined maternal...
Midlife smoking, diabetes, and hypertension associated with late life dementia
1. Based on results of the Atherosclerotic Risk in Communities (ARIC) prospective cohort, midlife vascular risk factors associated with dementia included smoking, diabetes, prehypertension,...
Despite adverse events, corticosteroids may benefit patients with IgA nephropathy
1. In this multicenter, double blind study, IgA nephropathy patients had improved kidney function with corticosteroid treatment compared to those treated with placebo.
2. Unfortunately,...
Orthostatic hypotension measurements done within one minute associated with adverse outcomes
1. In this prospective cohort study, measurements of orthostatic hypotension within one minute of standing were associated with higher odds of history of dizziness...
Homozygous complement component CD55 mutations cause novel gastrointestinal syndrome
1. Researchers used whole-exome sequencing to define the novel CHAPLE syndrome, characterized by a homozygous CD55 mutation with hyperactivation of complement, angiopathic thrombosis, and...
Lower rates of hypoglycemia in patients treated with insulin degludec
1. Treatment with insulin degludec resulted in a lower rate of overall symptomatic hypoglycemic episodes compared with insulin glargine U100.
2. Rates of nocturnal symptomatic...
