Nephrology

Reports of high-impact nephrology studies by medical professionals

The PIVOTOL trial: high-dose iron reduces incidence of serious adverse events in hemodialysis patients

1. Patients undergoing maintenance hemodialysis experienced fewer serious adverse events if treated proactively with high-dose intravenous iron sucrose compared to patients reactively treated with...

Quick Take: Neutrophil–Lymphocyte Ratio as a Predictor of Kidney Function Decline Among Diabetes and...

Diabetic nephropathy is a major concern for patients with diabetes and pre-diabetes. The neutrophil-lymphocyte ratio (NLR) in kidneys has prognostic value for cancers and...

Robust survival benefit seen in lupus nephritis patients receiving renal transplant

1. For patients with Lupus nephritis end stage renal disease (LN ESRD), renal transplant reduced the risk of death by about 70%.2. The risk...

Exome sequencing yields genetic diagnoses among patients with chronic kidney disease

1. Proband exome sequencing revealed that approximately 10% of patients in this study cohort had a detectable genetic variant of chronic kidney disease.2. A majority...

Vitamin D receptor activators may not reduce cardiovascular risk in patients undergoing hemodialysis.

1. In this randomized clinical trial, patients on hemodialysis who received a vitamin D receptor activator (VDRA) did not have better cardiovascular health compared...

Renin-angiotensin inhibitors may reduce mortality and heart failure readmissions in patients with transcatheter aortic...

1. In this retrospective cohort study of transcatheter aortic valve replacement (TAVR) patients, Renin-Angiotensin System (RAS) inhibitors administered at hospital discharge reduced mortality and...

Interpreting genetic variants in kidney and genitourinary disorders will likely require systematic curation of...

1. This secondary analysis of genetic data emphasized the high number of potentially “pathogenic” variants that are revealed through exome sequencing when analyzing a...

Quick Take: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

Patients undergoing hemodialysis typically receive intravenous iron, despite a lack of established clinical efficacy. In this randomized controlled trial, investigators randomized 2141 patients undergoing...

Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use linked with decreased mortality after inpatient...

1. In this retrospective cohort study looking at patients admitted to hospital with acute kidney injury, use of angiotensin-converting enzyme inhibitor or angiotensin receptor...

Intensive blood pressure lowering favored to not induce kidney disease, contrary to prior research

1. Patients managed with intensive blood pressure reduction were found to have significantly greater decreases in kidney damage biomarkers compared to standard blood pressure...

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