Polypharmacy is associated with higher risk of mortality and hospitalizations among older adults
1. Polypharmacy was associated with a higher risk of mortality and hospitalization at one-year and five-years among older adults aged...
Pharma
Oral nonstatin medication significantly lowers cholesterol in high-risk patients
1. In this randomized controlled trial, once-daily oral enlicitide was associated with sustained reductions in low-density lipoprotein cholesterol levels compared...
Sleeve gastrectomy may produce greater and more durable weight loss than semaglutide in patients with obesity
1. Sleeve gastrectomy produces substantially greater and more durable weight loss than semaglutide over 12 months in patients with obesity....
Fluoxetine may improve hemodynamic status and organ dysfunction in patients with severe sepsis
1. Adjunctive fluoxetine significantly reduced vasopressor duration and ICU length of stay in patients with severe sepsis. 2. Fluoxetine improved...
Perioperative esketamine may improve postoperative pain and mood outcomes after cesarean section
1. Intravenous esketamine provides effective adjunctive analgesia after cesarean delivery while also reducing postoperative inflammation and mood-related complications. 2. Esketamine...
![siRNA against antithrombin alleviates symptoms of hemophilia [PreClinical]](https://www.2minutemedicine.com/wp-content/uploads/2015/04/clot-CCWiki-350x250.jpg)
Tenecteplase not associated with visual improvement in central retinal artery occlusion
1. In this randomized controlled trial of adults with central retinal artery occlusion, tenecteplase administration shortly after symptom onset did...
Palbociclib as adjunct maintenance therapy prolongs progression-free survival in some types of metastatic breast cancer
1. This randomized controlled trial found that, in patients with hormone-receptor-positive, HER2-positive metastatic breast cancer, the addition of palbociclib to...
Sacituzumab govitecan plus pembrolizumab improves survival in advanced triple-negative breast cancer
1. Among patients with previously untreated programmed death-ligand 1 positive, triple-negative breast cancer, first-line sacituzumab govitecan plus pembrolizumab significantly prolonged...
Oral semaglutide reshapes everyday obesity visits
1. Oral semaglutide adds a pill-based option for chronic obesity care without changing the core GLP-1 tradeoffs in efficacy and...
An electronic intervention may increase chances of benzodiazepine cessation
1. An electronic intervention promoting self-management of benzodiazepine cessation significantly increased the chances of benzodiazepine cessation compared to placebo. Evidence...
