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Guselkumab (Tremfya) strengthens its case for protecting joints in psoriatic arthritis
1. The FDA has expanded the label for guselkumab (Tremfya) to include evidence that it can inhibit progression of structural...
Pharma
Why Pfizer Is Looking East for Its Next Generation of Cancer Drugs
1. Pfizer has committed $650 million upfront in a collaboration with Innovent Biologics that could ultimately reach $10.5 billion in...
2MM: Pharma Roundup – Pfizer’s $10.5B Innovent oncology partnership, Guselkumab (Tremfya) gains a broader psoriatic arthritis label, Venetoclax (Venclyxto) expands first-line CLL options, and Seladelpar (Livdelzi) advances in primary biliary cholangitis
Pfizer and Innovent deepen the China biotech licensing wave Pfizer is making another large oncology bet, this time through a...
Use of procalcitonin in neonatal late-onset sepsis may reduce the duration of antibiotic therapy without increase in mortality
1. Incorporating procalcitonin-guided decision making in the management of neonatal late-onset sepsis significantly reduced the duration of antibiotic treatment without...
A novel therapy targeting γ-aminobutyric acid is safe and may be effective in major depressive disorder
1. H3-10353, a novel γ-aminobutyric acid (GABA) positive allosteric modulator, is safe and well-tolerated in healthy patients and those with...
A lower volume of polyethylene glycol with ascorbate (MoviPrep) may improve bowel cleansing prior to colonoscopy
1. 1 litre polyethylene glycol with ascorbate (1L-PEG-Asc) showed superior bowel cleansing efficacy compared to 2 litre polyethylene glycol with...
Immunosuppression with systemic glucocorticoids close to initiation of immune checkpoint inhibitor is associated with worse survival outcomes
1. Exposure to systemic glucocorticoid immunosuppression (gsISP) close to immune checkpoint inhibitor (ICI) initiation was associated with worse overall survival...
Treatment of chronic low back pain and disc herniation with amoxicillin-clavulanate (Augmentin) may not be effective for pain control
1. In adult patients with chronic low back pain (LBP) and disc herniation on magnetic resonance imaging (MRI), treatment with...
Delayed initiation of antibiotic therapy is associated with worse outcomes in skin and soft tissue infections
1. Delayed initiation of antibiotic therapy was strongly associated with treatment failure and prolonged hospitalization in hospitalized SSTI patients. 2....
Selective serotonin reuptake inhibitors may reduce risk of total joint arthroplasty in osteoarthritis
1. Initiation of centrally acting analgesics in patients with osteoarthritis (OA) was associated with a higher long-term risk of total...
