Pre-hospital plasma transfusion in patients at risk of hemorrhagic shock decreases mortality

1. In patients at risk of hemorrhagic shock, the pre-hospital administration of thawed plasma decreased mortality at 24 hours and 30 days and patients...

Mean platelet counts shown to decrease during pregnancy

1. Retrospective analyses demonstrated evidence of mean platelet count decline during pregnancy beginning as early as the first gestational trimester 2. Platelet counts were significantly...

Alteplase unlikely to reduce disability after mild stroke without disabling deficits

1. In this randomized controlled trial, administration of alteplase within 3 hours of mild stoke did not lead to a reduction in disability at...

Active EKG monitoring screening leads to earlier diagnosis and treatment for atrial fibrillation compared...

1. In this randomized controlled trial, patients who received immediate atrial fibrillation (AF) monitoring with a new, wearable EKG were more likely to have...

Cross-sex hormone therapy raises risk for vascular events in transgender women

1. Transgender women had higher rates of venous thrombotic events (VTE) with cross-sex hormones. 2. Similar rates of ischemic stroke and myocardial infarction were found...

Quality improvement interventions increase adherence to performance measures for stroke in China

1. In this cluster-randomized clinical trial, quality improvement interventions led to slightly greater adherence of evidence-based, performance measures compared to care as usual for...

Family-support intervention does not significantly improve surrogates’ psychological symptoms: The PARTNER trial

1. Family-support intervention delivered by an interprofessional intensive care unit (ICU) team did not significantly reduce anxiety and depression among surrogates of critically ill...

Dupilumab reduces systemic glucocorticoid use in severe asthmatics

1. Glucocorticoid dependent severe asthmatics treated with dupilumab for 24 weeks used significantly lower doses of glucocorticoids while maintaining asthmatic control compared to placebo...

Insulin analogs compared to NPH not associated with reduced hypoglycemia-related hospitalizations

1. In this retrospective cohort study, for patients with type 2 diabetes, initiation of a basal insulin analog compared with NPH insulin was not...

Nearly Half of All Pediatric Buprenorphine Exposures Result in Hospitalization

1. The majority of buprenorphine exposures in children 19 years and younger reported to the National Poison Data System (NPDS) were among children <6...
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