Azithromycin does not reduce mortality in patients hospitalized with COVID-19

1. All-cause mortality at 28 days was similar between patients in the azithromycin group and usual care alone group. 2. There was no significant difference...

Antibiotic prophylaxis for UTIs in elderly patients associated with an increased risk of ED...

1. Among older adults with urinary tract infections, antibiotic prophylaxis was associated with an increased risk of ED visit or hospitalization for UTI, sepsis,...

Early head-to-pelvis CT imaging for patients experiencing out-of-hospital circulatory arrest is safe and effective...

1. Early head-to-pelvis CT imaging for patients experiencing out-of-hospital circulatory arrest is safe, expedites diagnosis, and can meaningfully impact management. Evidence Level Rating: 2 (Good) Out-of-hospital...

Posaconazole is non-inferior to voriconazole for primary treatment of invasive aspergillosis

1. Posaconazole  was non-inferior to voriconazole with respect to all-cause mortality at day 42 (15% vs. 21%, respectively). 2. Incidence of treatment-related adverse events was...

Risk factors for SARS-CoV-2 seropositivity in health care workers

1. Residence in a community with coronavirus disease 2019 (COVID-19) incidence, direct community contact with a positive case, and Black race were associated with...

Naltrexone-bupropion treatment provides a higher response for methamphetamine use disorder

1. Combinatorial naltrexone and bupropion treatment were shown to have a higher response than placebo for patients with methamphetamine use disorder. 2. Furthermore, a higher...

Lower oxygenation does not improve mortality in hypoxemic respiratory failure

1. A lower oxygenation target was shown not to decrease the 90-day mortality in patients with acute hypoxemic respiratory failure compared to a high...

Tocilizumab not superior to standard care in randomized controlled trial for severe COVID-19 patients

1. Tocilizumab was not superior to standard care after 15 days, for COVID-19 patients in serious condition. 2. Patients given tocilizumab had higher rates of...

Laryngeal mask airway may not be superior for neonate resuscitation

1. Ventilation with a cuffless laryngeal mask airway (LMA) was shown not to be superior to face-mask ventilation in lowering the incidence of early...

Self-obtained vaginal swabs for Neisseria gonorrhoeae and Chlamydia trachomatis found to be non-inferior to...

1. Among patients presenting in the emergency setting for possible sexually transmitted infection, a self-obtained vaginal swab was found to be non-inferior to provider-performed...

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