Lanadelumab may be an effective prophylactic treatment for hereditary angioedema

1. In this randomized controlled trial, prophylactic lanadelumab reduced attack frequency and severity in patients with hereditary angioedema compared to placebo.2. The most common...

Large spike in drug use-associated infective endocarditis linked with opioid epidemic

1. Researchers have identified a significant increase in hospitalizations due to infective endocarditis related to drug use.2. Heart valve surgeries among patients with drug...

Renin-angiotensin inhibitors may reduce mortality and heart failure readmissions in patients with transcatheter aortic...

1. In this retrospective cohort study of transcatheter aortic valve replacement (TAVR) patients, Renin-Angiotensin System (RAS) inhibitors administered at hospital discharge reduced mortality and...

Proton pump inhibitor co-therapy reduces gastrointestinal bleeding risk of oral anticoagulants

1. In this retrospective cohort study, rivaroxaban had the highest and apixaban had the lowest upper gastrointestinal bleeding (UGIB) risk.2. Proton Pump Inhibitor (PPI)...

Quick Take: Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt...

Deep learning approaches have been proposed as a way to facilitate the interpretation of chest radiographs in low resource settings. In this study, investigators...

The ODYSSEY OUTCOMES trial: Alirocumab associated with reduced ischemic events after acute coronary syndrome

1. Among patients that suffered a recent acute coronary syndrome (ACS) and had elevated levels of atherogenic lipoproteins despite intensive or maximum-intensive statin therapy,...

Omalizumab (XOLAIR®) could be a new rescue option for asthma

1. In a case-report, 41-year-old patient requiring intubation for respiratory failure due to status asthmaticus clinically improved after administration of omalizumab (XOLAIR®).2. The findings...

Quick Take: Sex differences in risk factors for myocardial infarction: cohort study of UK...

Coronary artery disease (CAD) is the leading cause of mortality worldwide. While it has been established that CAD-related mortality rates are significantly lower in...

Concussion or mild traumatic brain injury linked with increased risk of suicide

1. In this systematic review and meta-analysis, history of concussion or mild traumatic brain injury was associated with a two-fold increased risk of suicide.2....

Risk stratification criteria demonstrate high sensitivity for invasive bacterial infections among febrile infants

1. The Rochester criteria and the modified Philadelphia criteria were found to have the same sensitivity (greater than 80%) in identifying infants 29-60 days...

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