Use of aspirin for primary prevention linked to increased risk of intracranial hemorrhage

1. In this systematic review and meta-analysis, use of low-dose aspirin in patients without symptomatic cardiovascular disease was linked with an increased risk of...

Sodium-glucose cotransporter-2 inhibitors may be linked to Fournier gangrene

1. In this descriptive case series, 55 cases of patients with diabetes who developed Fournier gangrene while using sodium-glucose cotransporter-2 (SGLT2) inhibitors are described.2....

The EXTEND trial: neurological deficits decreased with thrombolysis up to 9 hours after stroke...

1. Patients presenting between 4.5 and 9 hours after stroke onset with viable brain tissue who received thrombolytic therapy had better neurological outcomes compared...

Patent foramen ovale associated with four-fold increased risk for ischemic stroke in patients with...

1. In this prospective cohort study, patients with symptomatic pulmonary embolism (PE) and a patent foramen ovale (PFO) were found to have a significantly...

The PRISM trial: Progesterone therapy does not alter birth outcomes in women with early...

1. Women with early pregnancy bleeding administered progesterone experienced similar rates of live births occurring after 34 weeks’ gestation as women treated with placebo.2....

Ticagrelor reversal agent provides immediate and sustained effect

1. A monoclonal antibody fragment to ticagrelor, PB2452, increased platelet function significantly in healthy patients given the oral P2Y12 inhibitor ticagrelor.2. Adverse effects were...

Trans-nasal cooling during cardiac arrest does not improve survival with good neurologic outcome

1. In this randomized controlled trial, intra-cardiac arrest, trans-nasal evaporative cooling did not improve survival with good neurologic outcome at 90 days compared to...

Quick Take: Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and...

Laparoscopic cholecystectomy for the treatment of symptomatic cholecystolithiasis is currently the standard of care. However, multiple studies indicate that 10-41% of patients continue to...

Quick Take: Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary...

Rivaroxaban is a selective direct factor Xa inhibitor that has been associated with improved outcomes in stable patients with chronic atherosclerotic cardiovascular disease and...

Provision of medically-tailored meals linked with lower admissions and medical spending

1. In this retrospective analysis from Massachusetts, the provision of ten ready-to-consult medically-tailored meals (MTMs) to participants was linked to fewer inpatient and skilled...
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