Drug treatment associated with a significant reduction in death risk following opioid overdose

1. Buprenorphine and methadone maintenance treatment (MMT) was associated with reduced death in opioid users. 2. No significant associations were found between naltrexone and all-cause...

Failures in using personal protective equipment are commonly observed

1. In this qualitative study, active failures in infectious agent transmission precaution practices were observed frequently. 2. Common failures include: failure to enter room with...

Lack of superiority of rivaroxaban for secondary prevention of embolic stroke of undetermined source

1. At a median follow-up of eleven months, rivaroxaban was not superior to aspirin for prevention of secondary stroke after an initial primary embolic...

Restricting perioperative fluid for abdominal surgery patients does not reduce complications: The RELIEF trial

1. Among patients at increased risk for complications undergoing abdominal surgery, those randomized to perioperative fluid restriction did not have increased disability-free survival at...

Medications with depression as a possible adverse effect associated with increased depression risk

1. In this cross-sectional study, the use of medications with depression as an adverse effect was associated with a higher prevalence of depression while...

Lower and higher oxygen saturation targets result in equal but contrasting outcomes for extremely...

1. In this meta-analysis, there was no significant difference between lower and higher oxygen saturation targets on a primary composite of mortality or major...

Increased attending supervision may not reduce medical errors and may decrease educational outcomes

1. In this randomized controlled trial, increasing direct attending physician supervision did not reduce the rate of medical errors. 2. The increased direct attending supervision...

Intensive management for sicker patients increases outpatient care but not costs

1. Patients who were apart of the intensive management group that were higher risk received greater outpatient care. 2. Overall mean costs between intensive management...

Survey-based priming intervention linked to improved communication and goals-of-care discussions amongst patient-clinician pairs

1. Goals-of-care (GOC) discussions were linked to improved patient outcomes and reduction of intensity in end-of-life care. The current study demonstrated that a survey-based...

Restrictive state alcohol policies may reduce alcohol-related crash fatalities

1. Increasingly restrictive state alcohol policies were associated with reduced odds that a crash fatality was alcohol related, both when blood alcohol levels were...
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