Patent foramen ovale associated with four-fold increased risk for ischemic stroke in patients with...

1. In this prospective cohort study, patients with symptomatic pulmonary embolism (PE) and a patent foramen ovale (PFO) were found to have a significantly...

The PRISM trial: Progesterone therapy does not alter birth outcomes in women with early...

1. Women with early pregnancy bleeding administered progesterone experienced similar rates of live births occurring after 34 weeks’ gestation as women treated with placebo.2....

Ticagrelor reversal agent provides immediate and sustained effect

1. A monoclonal antibody fragment to ticagrelor, PB2452, increased platelet function significantly in healthy patients given the oral P2Y12 inhibitor ticagrelor.2. Adverse effects were...

Trans-nasal cooling during cardiac arrest does not improve survival with good neurologic outcome

1. In this randomized controlled trial, intra-cardiac arrest, trans-nasal evaporative cooling did not improve survival with good neurologic outcome at 90 days compared to...

Quick Take: Restrictive strategy versus usual care for cholecystectomy in patients with gallstones and...

Laparoscopic cholecystectomy for the treatment of symptomatic cholecystolithiasis is currently the standard of care. However, multiple studies indicate that 10-41% of patients continue to...

Quick Take: Association of Rivaroxaban With Thromboembolic Events in Patients With Heart Failure, Coronary...

Rivaroxaban is a selective direct factor Xa inhibitor that has been associated with improved outcomes in stable patients with chronic atherosclerotic cardiovascular disease and...

Provision of medically-tailored meals linked with lower admissions and medical spending

1. In this retrospective analysis from Massachusetts, the provision of ten ready-to-consult medically-tailored meals (MTMs) to participants was linked to fewer inpatient and skilled...

Quick Take: Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children...

Convulsive status epilepticus (SE) is the most common life-threatening neurological emergency in pediatrics. It is associated with significant morbidity and mortality, with 22% of...

Older patients with STEMI and cardiogenic shock benefit from percutaneous coronary intervention

1. In this retrospective analysis of patients 75-years or older with ST-elevation myocardial infarction (STEMI) and cardiogenic shock, use of percutaneous coronary intervention (PCI)...

Rivaroxaban likely reduces risk of recurrent stroke in specific subgroup of patients with embolic...

1. In this post-hoc analysis of data from the NAVIGATE-ESUS trial, which evaluated strategies to prevent recurrent stroke in patient of embolic stroke of...
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