Biosimilar to infliximab shows equivalent safety and efficacy for treating Crohn’s disease
1. The biosimilar to infliximab, CT-P13 was shown in this study to have equivalent efficacy to the anti tumor-necrosis factor (TNF) monoclonal antibody for...
Proton pump inhibitor co-therapy reduces gastrointestinal bleeding risk of oral anticoagulants
1. In this retrospective cohort study, rivaroxaban had the highest and apixaban had the lowest upper gastrointestinal bleeding (UGIB) risk.2. Proton Pump Inhibitor (PPI)...
Quick Take: Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis
The use of probiotics has been suggested as a way to improve outcomes in children with gastroenteritis. In this randomized controlled trial, investigators randomized...
The TARGET: Energy density of enteral nutrition not associated with mortality
1. Patients undergoing mechanical ventilation randomized to receive energy-dense enteral nutrition experienced similar rates of mortality at 90-days compared to patients treated with routine...
Gastric bypass most effective for weight loss among common bariatric procedures
1. Roux-en-Y gastric bypass was found to be the most effective bariatric procedure reviewed in this study in terms of patient weight loss.2. The...
Quick Take: Effect of lorcaserin on prevention and remission of type 2 diabetes in...
There is a strong relationship between body weight and the risk of developing diabetes. Lorcaserin is a selective serotonin 2C receptor agonist that suppresses...
Lorcaserin does not increase rate of cardiovascular events in overweight or obese patients
1. At a median follow-up of 3.3 years, rates of composite cardiovascular events in at-risk overweight or obese patients treated with lorcaserin were not...
Tailoring fecal immunochemical tests positivity thresholds by age and sex may help to optimize...
1. Cancer detection among participants was higher with lower positivity thresholds.2. Sensitivity with conventional fecal immunochemical tests (FIT) thresholds decreased with increasing age and...
Transplantation followed by antiviral therapy cured hepatitis C in 100 percent of patients receiving...
1. All 20 patients included in the study were cured of HCV following antiviral therapy.2. Similar eGFR scores were found between nontransplant and transplant...
Patisiran is effective in treatment of hereditary transthyretin amyloidosis.
1. Patisiran, an RNA interference agent, improved neuropathy symptoms and motor function in patients with hereditary transthyretin amyloidosis after 18 months of use.2. Types...
