Gastroenterology

Reports of high-impact gastroenterology studies by medical professionals

Community members successfully implement school-based health programs

1. The Incidence of diarrheal illness decreased by almost 50% among rural primary school children at low-cost private schools in rural India who received...

Quick Take: Comparison of Laparoscopic 270 Degree Posterior Partial Fundoplication vs Total Fundoplication for...

Gastroesophageal reflux disease (GERD) is a common disorder associated with reflux of gastric contents through the gastroesophageal junction. There are a wide variety of...

CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]

1. Haploinsufficiency of Sim1 or Mc4r in the hypothalamus result in an obesity phenotype in mice and humans.2. In mice, CRISPR-mediated activation (CRISPRa) of...

Aspirin therapy combined with warfarin without clinical indication associated with increased bleeding

1. In this retrospective cohort study conducted in Michigan, aspirin therapy combined with warfarin for patients without a clinical indication was associated with increased...

Genetic variants in NUDT15 associated with increased risk of thiopurine-induced myelosuppression

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk...

Quick Take: Assessment of Trends in Transplantation of Liver Grafts From Older Donors and...

With an ever-increasing aging general population, older adults have the potential to contribute to an expansion of the donor pool. Organs from older donors...

RNA interference agent givosiran appears safe in phase I trial

1. Among patients with acute intermittent porphyria (AIP), there was no difference in the proportion of any and serious adverse events reported between those...

Quick Take: Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind,...

Several recently published guidelines regarding the treatment of C. difficile infection recommend vancomycin as first-line antibiotic treatment. However, given the recent increase in severity...

Porphyria recurrence in a transplant recipient illustrates the need for genetic screening of related...

1. A patient with acute intermittent porphyria received a liver transplant from a brother which was expected to be curative, but her symptoms recurred.2....

Quick Take: Association of maternal probiotic supplementation with human milk oligosaccharide composition

Human milk oligosaccharides (HMO) are complex glycans, and are typically non-digestible by humans. They are, however, important substrates for an infant’s gut microbiota, and...
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