Gastroenterology

Reports of high-impact gastroenterology studies by medical professionals

Very-low-calorie diet leads to significant but reversible changes in gut microbiome

1. Very-low-calorie diet significantly altered composition of the gut microbiome in study participants, including an enrichment in pathogenic Clostridiodies difficile. 2. Stool samples from post-diet...

Combination therapy using conformation-specific KIT inhibitors associated with clinical benefit in patients with advanced...

1. The use of a type I KIT inhibitor, such as PLX9486, in combination with a type II inhibitor, such as sunitinib, was associated...

Neoadjuvant apatinib therapy for locally advanced gastric cancer associated with high R0 resection rate

1. Neoadjuvant treatment of apatinib combined with S-1 plus oxaliplatin (SOX) was shown to be an effective treatment modality, resulting in a 75% R0...

Adjunctive nivolumab reduces risk of death and progression of gastric adenocarcinoma compared to chemotherapy...

1. Overall survival and progression-free survival were higher for patients on nivolumab plus chemotherapy compared to chemotherapy alone. 2. Severe adverse events occurred more frequently...

Efruxifermin an effective and safe treatment for nonalcoholic steatohepatitis

1. Efruxifermin was an effective and safe treatment found to significantly reduce hepatic fat fraction in order to treat nonalcoholic steatohepatitis.  2. Participants taking Efruxifermin...

Tai Chi may be effective in reducing waist circumference

1. Tai Chi was shown to be as effective as conventional exercise in reducing waist circumference in adults with central obesity. 2. A 12-week Tai...

Filgotinib effectively induces and maintains clinical remission in patients with ulcerative colitis

1. At weeks 10 and 58, more patients in the filgotinib 200 mg group experienced clinical remission compared with the placebo group. 2. The proportion...

Transglutaminase 2 inhibition attenuates mucosal injury in patients with celiac disease

1. ZED1227, a selective oral transglutaminase 2 inhibitor, was shown to reduce gluten-induced deterioration of intestinal mucosa in patients with celiac disease. 2. No significant...

Neoadjuvant pembrolizumab with chemoradiotherapy not supported for locally advanced rectal cancer after chemotherapy treatment

1. Although combining pembrolizumab to chemoradiotherapy as part of total neoadjuvant therapy after FOLFOX (5-fluorouracil, leucovorin, and oxaliplatin) treatment was safe overall, the difference...

Neoadjuvant chemoradiotherapy plus surgery increases overall survival of patients with advanced esophageal squamous cell...

1. Neoadjuvant chemoradiotherapy (NCRT) with surgery improves the death rate, overall survival, disease-free survival time, and locoregional and distal recurrence rates of advanced esophageal...

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