Pulmonology

Reports of high-impact pulmonology studies by medical professionals

Tezacaftor-ivacaftor improves pulmonary function in cystic fibrosis patients: The EVOLVE trial

1. Tezacaftor-Ivacaftor significantly improves lung function and reduces the frequency of pulmonary exacerbations in cystic fibrosis (CF) patients homozygous for the Phe508 deletion (Phe508del). 2....

CFTR modulation therapy improves predicted FEV1 in patients with heterozygote residual function cystic fibrosis

1. Absolute change in predicted forced expiratory volume in 1 second (FEV1) improved significantly over a 4 and 8-week period among patients assigned tezacaftor-ivacaftor...

Randomized trial suggests that self-administered latent tuberculosis treatment is noninferior to direct observation

1. Once-weekly isoniazid (INH) and rifapentine treatment for latent tuberculosis infection (LTBI) via self-administered therapy (SAT) had high completion rates in the United States...

Despite improving trends in lupus-related mortality, rates appear to remain high relative to non-lupus...

1. Over the 46-year study period, systemic lupus erythematosus (SLE) age-standardized mortality rates (ASMRs) did not decline as much as non-SLE ASMR, and there...

High nicotine concentration in e-cigarettes linked to increased smoking and vaping in teenagers

1. In this study of self-reported habits of teenagers, use of e-cigarettes with greater nicotine concentration was associated with incremental increase in odds of...

Supplemental oxygen does not reduce mortality in stroke patients

1. This randomized clinical trial showed that among patients with acute stroke, supplementary low-dose oxygen for 72 hours (either nocturnal or continuous) did not...

Mortality rates in the US from respiratory diseases increased from 1980 to 2014

1. In this retrospective analysis of mortality data from a number of national databases, the mortality rates from respiratory diseases increased between 1980 and...

Total mucin concentration is associated with chronic bronchitis phenotype

1. Total airway mucin concentration was significantly elevated in current or former smokers with chronic bronchitis compared to non-smoker controls, and correlated with disease...

Tiotropium linked with improved outcomes in early-stage COPD

1. Patients with mild or moderate COPD (chronic obstructive pulmonary disease) randomized to receive tiotropium had a significantly higher FEV1 (forced expiratory volume in...

Rapid tests linked to quicker and more accurate results for influenza diagnosis than traditional...

1. Compared to traditional rapid influenza diagnostic tests (RIDTs), digital immunoassays (DIAs), and rapid nucleic acid amplification tests (NAATs) had significantly higher sensitivities for...
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