Total mucin concentration is associated with chronic bronchitis phenotype
1. Total airway mucin concentration was significantly elevated in current or former smokers with chronic bronchitis compared to non-smoker controls, and correlated with disease...
Tiotropium linked with improved outcomes in early-stage COPD
1. Patients with mild or moderate COPD (chronic obstructive pulmonary disease) randomized to receive tiotropium had a significantly higher FEV1 (forced expiratory volume in...
Rapid tests linked to quicker and more accurate results for influenza diagnosis than traditional...
1. Compared to traditional rapid influenza diagnostic tests (RIDTs), digital immunoassays (DIAs), and rapid nucleic acid amplification tests (NAATs) had significantly higher sensitivities for...
Sleep disordered breathing linked to impaired cognitive function
1. In this meta-analysis of available studies, prospective data demonstrated that sleep-disordered breathing (SDB) is associated with an increased risk of developing cognitive impairment.
2....
Small-molecule inhibitor may reduce chemotherapy-associated metastases [PreClinical]
1. In a mouse model of breast cancer, treatment with the chemotherapy paclitaxel (Ptx) enhanced tumor cell dissemination and the formation of micrometastatic lung...
Extensive cancer screening may not improve outcomes for patients with unprovoked venous thromboembolism
1. Although more extensive screening may detect more cases of occult cancer in patients with unprovoked venous thromboembolism (VTE) at the preliminary screening, it...
Levosimendan not effective in reducing postoperative low cardiac output syndrome in select heart surgery...
1. Compared with placebo, levosimendan did not reduce the need for prolonged catecholamine infusion, use of left ventricular assist device, or renal replacement therapy...
E-cigarette use linked to increased risk of cigarette smoking in adolescents and young adults
1. In this meta-analysis of available studies about youths’ use of e-cigarettes was associated with increased risk of initiation for cigarette smoking and past...
Benralizumab reduces oral steroid use in severe asthmatic patients
1. Use of the interleukin-5 receptor antibody benralizumab lowered oral glucocorticoid use while maintaining symptomatic control in patients with severe asthma on chronic oral...
Drug improves cystic fibrosis pulmonary inflammation and protein function [PreClinical]
1. Thymosin α1 (Tα1), an immunomodulatory drug currently in use, decreased lung inflammation in a mouse model of cystic fibrosis (CF).
2. In mice, administration...
