Characteristics and strength of evidence of covid-19 studies registered on clinicaltrials.gov
1. While there has been a rise in clinical trials on COVID-19, a large proportion of these studies are expected to yield low levels...
Anti-anaerobic therapy over-prescribed for patients with aspiration community-acquired pneumonia
1. Nearly all patients hospitalized for community-acquired pneumonia have at least one risk factor for aspiration, though few present with clinical aspiration pneumonia.
2. Bacterial...
Hydroxychloroquine and azithromycin do not improve clinical outcomes in mild-to-moderate Covid-19
1. Hydroxychloroquine use with or without azithromycin did not improve clinical outcomes at fifteen days when compared with standard of care in hospitalized patients...
Lung recruitment improves efficacy of surfactant treatment in extremely preterm neonates
1. The intubation-recruitment-surfactant administration-extubation procedure reduced the need for invasive ventilation in extremely preterm neonates compared to those not receiving lung recruitment.
2. There...
Neonatal outcomes in 29 pregnant women with COVID-19: A retrospective study in Wuhan, China
1. Approximately 41.4% of neonates born to COVID-19-positive women in Wuhan, China presented with radiological findings of pneumonia
2. Limited sample size and comparisons limit...
Hematological and coagulation parameters may predict outcomes in COVID-19
1. Hematological tests including platelet count, prothrombin time (PT), D-dimer, and neutrophil-to-lymphocyte ratio can aid clinical decision making in managing patients with COVID-19, and...
Prophylactic nirsevimab treatment reduces RSV risk in infants
1. Prophylactic nirsevimab lowered the incidence of respiratory syncytial virus (RSV)-associated lower respiratory tract infection compared to the placebo group.
2. Nirsevimab had a favorable...
RSV fusion protein vaccine not effective
1. The respiratory syncytial virus (RSV) fusion (F) vaccine given to pregnant women did not meet efficacy criteria against RSV-associated lower respiratory tract infection...
Dual therapy more beneficial than monotherapy in poorly controlled asthma
1. Fixed-dose combinations of mometasone furoate and indacaterol acetate showed greater improvements in lung function parameters compared to inhaled corticosteroid monotherapy in patients with...
No association between influenza vaccine exposure in utero and adverse childhood health outcomes
1. In a systematic review, in utero exposure to influenza vaccine was not associated with adverse health outcomes in children older than 6 months...
