Neurology

Reports of high-impact neurology studies by medical professionals

Traumatic brain injury associated with higher rate of suicide

1. In this retrospective study, Traumatic Brain Injury (TBI) was associated with a doubling in deaths by suicide, especially within the 6 months post-TBI.  2....

Patisiran is effective in treatment of hereditary transthyretin amyloidosis.

1. Patisiran, an RNA interference agent, improved neuropathy symptoms and motor function in patients with hereditary transthyretin amyloidosis after 18 months of use. 2. Types...

Viral vector based gene therapies show promise for treating focal epilepsy [PreClinical]

1. Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons. 2. Treatment of rats with a lentiviral...

Alteplase unlikely to reduce disability after mild stroke without disabling deficits

1. In this randomized controlled trial, administration of alteplase within 3 hours of mild stoke did not lead to a reduction in disability at...

Quality improvement interventions increase adherence to performance measures for stroke in China

1. In this cluster-randomized clinical trial, quality improvement interventions led to slightly greater adherence of evidence-based, performance measures compared to care as usual for...

Neonatal neuroimaging with strong negative predictive value for developmental outcomes: The NEURO study

1. In multivariate analyses, adverse late cranial ultrasound findings (CUS) were an independent risk factor for full scale IQ scores <70 (FSIQ <70). Adverse late...

Prenatal antidepressant exposure may increase risk of poor motor development

A meta-analysis of 18 studies examining the association of prenatal antidepressant exposure with motor development in children showed a small overall effect of worse...

Lack of superiority of rivaroxaban for secondary prevention of embolic stroke of undetermined source

1. At a median follow-up of eleven months, rivaroxaban was not superior to aspirin for prevention of secondary stroke after an initial primary embolic...

MRI pattern selects patients with unknown stroke time who benefit from thrombolysis

1. Stroke patients with unknown time of stroke onset and DWI-FLAIR mismatch indicative of a stroke within the prior 4.5 hours who were randomized...

Cannabidiol plus conventional antiepileptics reduces drop seizure frequency in the Lennox-Gastaut syndrome

1. Amongst adults and children with the Lennox-Gastaut (LG) syndrome, addition of cannabidiol to a conventional antiepileptic regimen reduced drop seizure frequency compared to...
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