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✦EvidencePulse™by 2 Minute Medicine3 reportsYou askedtop stroke trials 2026Synthesizing medical evidence...Top 2026 stroke trial results:OCEANIC — ischemic stroke: 6.2% vs 8.4%OPTION* — mRS 0–1: 43.6% vs 34.2%ORIENTAL* — mRS 0–2: 58.6% vs 46.6%*Higher sICH in intervention armsParticipants randomizedNOCEANIC12,327OPTION570ORIENTAL564Ask about guidelines or landmark trials...↑Try EvidencePulse™Ask the evidence. Get the signal.Try it now →
Home All Specialties Chronic Disease

Reductions in pain catastrophizing are associated with improvements in emotional functioning

byPaary BalakumarandAlex Chan
June 22, 2025
in Chronic Disease, Neurology
Reading Time: 2 mins read
Pain relief collage: an engraved nerve cell with a fading teal signal, a willow sprig with catkins and over-ear headphones
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1. Reductions in pain catastrophizing are more closely associated with improvements in emotional functioning than with pain intensity

Evidence Rating Level: 2 (Good) 

This prospective observational study investigated whether pain catastrophizing, a maladaptive cognitive-emotional response to pain, is a static trait or a dynamic state influenced by interventional treatment outcomes. Among 128 adults with chronic low back pain (cLBP) undergoing fluoroscopic-guided steroid-based injections, the authors assessed changes in Pain Catastrophizing Scale (PCS) and Brief Pain Inventory (BPI) scores at baseline and one month post-procedure. Despite moderate improvements in pain severity and interference (especially in the affective REM domain: relationships, enjoyment, mood), the reduction in PCS scores was not statistically significant (mean change: −2.41, p=0.12), and the study was underpowered for this outcome. Notably, regression analysis identified baseline PCS and changes in REM as the strongest predictors of follow-up PCS scores, while pain severity, activity-related pain (WAW domain), and demographic or clinical variables (e.g., opioid use, prior surgery) were not significant predictors. Correlation analysis revealed that improvement in emotional-affective domains of functioning, rather than pain intensity alone, was more closely tied to reductions in catastrophizing. These findings suggest that emotional recovery may be a more relevant therapeutic target than sensory pain relief alone when aiming to reduce maladaptive pain coping mechanisms. The study also supports conceptualizing catastrophizing as a modifiable psychological state rather than a fixed trait.

Click to read the study in RAPM

Image: PD

©2025 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the authors or by 2 Minute Medicine, Inc. 

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