mRNA-1273 SARS-CoV-2 vaccine likely effective in nonhuman primates
1. Nonhuman primate vaccination with messenger RNA (mRNA)-1273 induced rapid neutralizing activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
2. The mRNA-1273 vaccine conferred...
Postexposure prophylactic use of hydroxychloroquine not effective for Covid-19 prevention
1. Prophylactic use of hydroxychloroquine within four days after exposure did not decrease cumulative incidence of coronavirus disease 2019 (Covid-19).
2. No arrhythmias or deaths...
Further evidence that Zika virus disease associated with brain and eye birth defects
1. The prevalence of brain and eye defects was elevated during the 2015-2016 Zika virus outbreak in Colombia compared to the periods immediately before...
Characteristics of COVID-19 in febrile infants 2 months of age and younger
1. In a case series of febrile infants age 60 days or younger admitted to a New York City hospital, no patient had severe...
Anti-anaerobic therapy over-prescribed for patients with aspiration community-acquired pneumonia
1. Nearly all patients hospitalized for community-acquired pneumonia have at least one risk factor for aspiration, though few present with clinical aspiration pneumonia.
2. Bacterial...
Hydroxychloroquine and azithromycin do not improve clinical outcomes in mild-to-moderate Covid-19
1. Hydroxychloroquine use with or without azithromycin did not improve clinical outcomes at fifteen days when compared with standard of care in hospitalized patients...
COVID-19 mRNA-1273 vaccine safe and immunogenic in phase 1 trial
1. The mRNA-1273 SARS-CoV-2 (COVID-19) vaccine was shown to be safe and immunogenic amongst the 45 COVID-19 negative participants in this phase 1 clinical...
Perinatal transmission of COVID-19 unlikely to occur with appropriate infection control strategies
1. Among neonates born to SARS-CoV-2-positive mothers in three New York Hospitals, none tested positive, or were symptomatic, for the virus at 24 h...
Hematological and coagulation parameters may predict outcomes in COVID-19
1. Hematological tests including platelet count, prothrombin time (PT), D-dimer, and neutrophil-to-lymphocyte ratio can aid clinical decision making in managing patients with COVID-19, and...
Prophylactic nirsevimab treatment reduces RSV risk in infants
1. Prophylactic nirsevimab lowered the incidence of respiratory syncytial virus (RSV)-associated lower respiratory tract infection compared to the placebo group.
2. Nirsevimab had a favorable...
