Replacement of recipient hematopoietic cells with donor cells may be a major factor in...
1. Allo-HSCT treatment resulted in significant prolonged reduction in HIV-1 viral reservoirs.
2. Mouse models showed adoptive transfer of peripheral CD4+ T cells to immunosuppressed...
Early and delayed renal-replacement therapy for septic shock associated acute kidney injury show similar...
1. Among patients with septic shock and acute kidney injury (AKI), there was no significant difference in 90-day mortality between early (within 12 hours)...
Recurrence of Group B Streptococcal infection similar in shortened and prolonged therapy
The rates of Group B Streptococcal (GBS) bacteremia recurrence in infants with an initial course of late-onset infection who received shortened and prolonged IV...
Polymyxin B hemoperfusion unlikely to reduce mortality for sepsis
1. In this randomized controlled trial, hemoperfusion with polymyxin B resulted in similar 28-day mortality compared to sham hemoperfusion for patients with sepsis with...
Acetaminophen reduces recurrence of febrile seizures in children within same fever episode
1. Rectal acetaminophen reduces rates of second febrile seizure (FS) in children during the course of the same febrile illness when given rectally soon...
Use of piperacillin-tazobactam (Zosyn) likely less effective than meropenem for ceftriaxone-resistant gram-negative bacteremia
1. In this randomized controlled trial, piperacillin-tazobactam was not found to be non-inferior to meropenum for all-cause mortality at 30 days among patients with...
Baloxavir reduces influenza viral load and duration of symptoms
1. The antiviral agent baloxavir (baloxavir marboxil) decreased duration of influenza symptoms significantly more than in patients treated with either placebo or oseltamivir.
2. Baloxavir...
More data needed to determine safety of probiotics and prebiotics
1. Studies are often lacking or inadequate with respect to reporting adverse events (AEs) related to probiotics and prebiotics.
2. The majority of the studies...
Using HCV-infected kidneys greatly reduces wait time for transplantation and improves survival for patients...
1. Use of HCV-infected kidneys increased patients’ quality-adjusted life expectancy.
2. Lower costs were associated with HCV-infected kidneys compared to transplanting HCV-uninfected kidneys to HCV-positive...
Primary HPV testing may detect cervical neoplasms earlier and more accurately than cytology
1. In this Canadian, randomized controlled trial, the use of primary HPV testing compared with cytology resulted in a significantly lower likelihood of CIN3+...
