Ensitrelvir associated with reduced risk of Covid-19 among household contacts
1. In this randomized controlled trial, household contacts of patients with Covid-19 who received ensitrelvir shortly after exposure had reduced...
Infectious Disease
Reports of high-impact infectious disease studies by medical professionals
Delayed initiation of antibiotic therapy is associated with worse outcomes in skin and soft tissue infections
1. Delayed initiation of antibiotic therapy was strongly associated with treatment failure and prolonged hospitalization in hospitalized SSTI patients. 2....
Adjuvanted influenza vaccines and high-dose influenza vaccines may have similar effectiveness in adult patients
1. Adjuvanted influenza vaccines did not differ significantly in effectiveness compared to high-dose influenza vaccines against laboratory-confirmed influenza and influenza-related...
![Shorter moxifloxacin-containing regimens ineffective for treating TB [REMoxTB trial]](https://www.2minutemedicine.com/wp-content/uploads/2014/09/TB-original-e1591582219420-350x250.jpg)
Near-point-of-care molecular test accurately detects pulmonary tuberculosis
1. In patients with presumptive pulmonary tuberculosis, the MiniDock MTB molecular test using sputum and tongue swabs showed diagnostic accuracy...
Nirmatrelvir–ritonavir does not improve severe outcomes in adults vaccinated against COVID-19
1. In two large randomized platform trials, early treatment with nirmatrelvir–ritonavir did not reduce hospitalization or death among mostly vaccinated,...
COVID-19 vaccination is associated with reduced risk of new-onset atrial fibrillation following COVID-19 infection
1. COVID-19 vaccination was associated with a reduced 24-month risk of new-onset atrial fibrillation/flutter after COVID-19 infection. Evidence Rating Level:...
Shorter antibiotic courses non-inferior for inpatient community-acquired pneumonia
1. In this target trial emulation, a shorter antibiotic course (3 to 4 days) demonstrated a similar 30-day all-cause mortality...
Next-generation yellow fever vaccine shows comparable efficacy to standard vaccine
1. A next-generation live-attenuated yellow fever vaccine (vYF) demonstrated noninferior immunogenicity compared to the standard vaccine, with nearly universal seroconversion...
Smallpox therapy tecovirimat not efficacious in treating clade II mpox
1. In this phase 3, randomized, placebo-controlled trial, an antiviral medication approved for treating smallpox (tecovirimat) did not accelerate clinical...
The quadrivalent human papillomavirus vaccine provides effective and durable protection against invasive cervical cancer
1. In this cohort study, the quadrivalent human papillomavirus (HPV) vaccine provides strong, long-lasting protection against invasive cervical cancer, with...
