Infectious Disease

Reports of high-impact infectious disease studies by medical professionals

Screening for vaccine hesitancy not associated with decreased under-immunized time

1. In this cluster randomized controlled trial, researchers found that informing providers of which parents identified as vaccine hesitant on a standard screening survey...

Efficacy of antibiotic treatment in patients with chronic low back pain and Modic changes...

1. A three-month course of amoxicillin provides no clinically significant benefit over placebo for treatment of chronic back pain with previous disc herniation and...

Wide variability in rate of antibiotic exposure among infants in NICU

1. Across the state of California, there was greater than 100-fold variability in the number of infants treated with antibiotics per proven bloodstream infection,...

Maribavir safety and efficacy for cytomegalovirus infections among transplant recipients

1. This phase 2, parallel-group randomized control trial compared the safety and efficacy profile of maribavir versus valgancicvlovir among patients who received solid organ...

Vitamin C may not provide benefit in sepsis with acute respiratory failure

1. In this randomized clinical trial, intravenous infusion of high-dose vitamin C vs placebo for 96 hours resulted in no significant differences in the...

Lefamulin noninferior to moxifloxacin for community-acquired pneumonia

1. In this randomized controlled trial, oral lefamulin was noninferior to oral moxifloxacin for treating community-acquired pneumonia, with regards to early clinical response at...

Antimicrobial administration may dramatically reduce blood culture sensitivity in septic patients

1. In this prospective multicenter observational trial among adult patients with severe manifestations of sepsis, administration of antimicrobial treatment prior to collection of blood...

Excess antibiotic use for pneumonia associated with increase adverse events

1. In this retrospective cohort study, excess days of antibiotic treatment were not associated with reduced adverse outcomes.2. Patients who took prolonged doses of...

N95 masks may have similar efficacy to medical masks for influenza prevention

1. In this randomized controlled trial among outpatient health care personnel, N95 respirators were similar to medical masks for preventing laboratory-confirmed influenza.2. N95 respirators...

The NAMSAL ANRS 12313 trial: HIV viral suppression similar for dolutegravir and low-dose efavirenz...

1. For previously untreated HIV-1 patients in Cameroon, treatment with dolutegravir was noninferior to low dose efavirenz at lowering viral load over a period...
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