Intensive blood pressure control reduces major cardiovascular event risk in type 2 diabetes patients
1. In this parallel design, randomized trial, intensive treatment of systolic blood pressure (SBP) resulted in a lower incidence of...
Lack of sentinel-lymph node biopsy does not alter survival in early invasive breast cancer
1. In this randomized, non-inferiority trial, the omission of surgical axillary staging was noninferior to sentinel lymph node biopsy in...
Adjunctive middle meningeal artery embolization superior to standard care in symptomatic chronic subdural hematomas
1. In this randomized controlled trial, middle meningeal artery embolization demonstrated a decreased risk of treatment failure in patients with...
Intraosseous drug administration does not improve survival in out of hospital cardiac arrest
1. In this randomized trial, intraosseous-first vascular access did not result in higher 30-day survival than intravenous-first strategies in adults...
Cabozantinib significantly improves progression free survival in patients with advanced neuroendocrine tumors
1. In this randomized controlled trial, cabozantinib significantly improved progression-free survival in patients with progressive pancreatic and extra-pancreatic neuroendocrine tumors....
Depemokimab therapy reduces exacerbations in patients with severe eosinophilic asthma
1. In this randomized, placebo-controlled replicate trial, depemokimab decreased the annual rate of exacerbations among patients with severe eosinophilic asthma....
Bedaquiline monotherapy may be effective at improving multibacillary leprosy.
1. In this proof-of-concept study, bedaquiline therapy cleared Mycobacterium leprae by four weeks of treatment in patients with multibacillary leprosy....
Fractional dosing of pneumococcal conjugate vaccine noninferior to full dosing schedule
1. In this randomized non-inferiority trial, 40% of a full dose of the 13-valent pneumococcal conjugate vaccine (PCV13) was noninferior...
Adjunctive middle meningeal artery embolization may reduce the recurrence of subdural hematomas
1. In this randomized controlled trial, middle meningeal artery embolization plus surgical evacuation was associated with a lower risk of hematoma...
Neoadjuvant ipilimumab plus nivolumab improves event-free survival in stage III melanoma
1. In this randomized controlled trial, two cycles of neoadjuvant ipilimumab plus nivolumab resulted in longer event-free survival than adjuvant...