Triple combination antihypertension therapy improves blood pressure control for mild-to-moderate hypertension

1. In this randomized controlled trial, patients receiving triple combination antihypertension therapy (TCAT) were more likely to achieve their blood pressure target compared to...

Traumatic brain injury associated with higher rate of suicide

1. In this retrospective study, Traumatic Brain Injury (TBI) was associated with a doubling in deaths by suicide, especially within the 6 months post-TBI.  2....

Microtubules linked to cardiomyocyte function in heart failure [PreClinical]

1. Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch. 2. Pharmacologic and genetic strategies to inhibit the detyrosination of...

Nonmedical expenses of pediatric hospitalizations have disproportionate effects

1. Caregivers of hospitalized children had median nonmedical expenses and lost wages totaling $51.4 per day of hospitalization. 2. Cost burden as a proportion of...

Bariatric surgery linked to significant reduction in microvascular complications of type 2 diabetes

1. Patients who received gastric bypass surgery had lower rates of diabetic neuropathy at follow up that remained stable throughout the study. 2. Bariatric surgery...

Risk of autism in offspring linked to maternal pregestational diabetes and severe obesity

1. Maternal prepregnancy obesity without pregestational diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) was associated with a slightly increased risk of having a...
Classics Series, Landmark Trials in Medicine

Anastrazole superior to tamoxifen for breast cancer treatment [Classics Series]

1. Postmenopausal women with advanced breast cancer randomized to anastrazole as first-line therapy experienced an increase in time to progression and a more favorable...

Women internists earn less than men whether they are generalists, hospitalists, or sub-specialists

1. The median annual salary gap between male and female respondents was $50 000. 2. Greater gender salary gaps occurred in subspecialists than for general...

Dengue serostatus impacts vaccine safety

1. Among dengue-seronegative individuals 2 to 16 years of age, there was a significantly increased risk of hospitalization and severe virologically confirmed dengue (VCD)...

Transplantation followed by antiviral therapy cured hepatitis C in 100 percent of patients receiving...

1. All 20 patients included in the study were cured of HCV following antiviral therapy. 2. Similar eGFR scores were found between nontransplant and transplant...
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