The 3 Wishes Project: a valuable program to improve end-of-life care

1. The 3 Wishes Project (3WP), which strives to provide humanistic care and honor the dignity of end-of-life (EOL) patients, was shown to be...

Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease

Selective Vulnerability of the Nucleus Basalis of Meynert Among Neuropathologic Subtypes of Alzheimer Disease1. Widespread cholinergic deficits found in early-onset Alzheimer’s disease (AD) may...

Among young adults, marijuana use increased and tobacco use decreased

1. Among college students in the United States from 2002 to 2016, overall marijuana use increased, while rates of tobacco smoking decreased.2. Among young...

Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity...

1. Acetaminophen burden, as measured by cord plasma samples, was associated with increased, dose-dependent risk of childhood Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder.Evidence Rating...

Effect of Continued Folic Acid Supplementation Beyond the First Trimester of Pregnancy on Cognitive...

1. Folic acid supplementation prevents neural tube deficits during pregnancy, but if continued beyond the recommended first trimester, may positively impact neurodevelopment and cognitive...

Combined Encorafenib-Binimetinib-Cetuximab therapy associated with longer overall survival in patients with BRAF V600E-mutated coloreactal...

1. A phase 3 randomized clinical trial showed that combined therapy using a BRAF inhibitor (encorafenib), EGFR monoclonal antibody (cetuximab) and a MEK inhibitor...

Long-term cognitive behavioral therapy may reduce healthcare costs versus second-generation antidepressants

1. In this modeling study comparing the cost-effectiveness of cognitive behavioral therapy (CBT) with second-generation antidepressants (SGA) for initial treatment of depression, neither strategy...

Lung cancer screening according to existing guidelines is likely cost-effective

1. In this study comparing three prominent lung cancer screening strategies, all were found to be cost-effective, yielding incremental cost-effectiveness ratios of under $100,000/quality...

Metoprolol not effective in preventing exacerbations of chronic obstructive pulmonary disease

1. In this double-blind randomized trial of COPD patients without previous indication for beta blocker therapy, treatment with extended-release beta-blockers failed to generate improved...

Ticagrelor alone non-inferior after one month post drug eluting stent placement

1. In this pre-specified ancillary study of a randomized control trial, ticagrelor alone after one month was found non-inferior, but not superior, to dual...
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