Declining blood pressure in elderly associated with subcortical microinfarcts

1. By comparing the baseline blood pressures and BP trends of elderly individuals with or without subcortical or cortical microinfarcts at autopsy, the authors...

Recombinant viral vector treatment sustains endogenous factor IX activity in patients with hemophilia B

1. A one-time infusion of a recombinant viral vector with a highly expressed factor IX gene resulted in sustained endogenous factor IX coagulant activity...

Pharmacomechanical thrombolysis does not lower risk of post-thrombotic syndrome: The ATTRACT trial

1. Patients with proximal deep venous thrombosis (DVT) experience similar rates of post-thrombotic syndrome (PTS) when treated with pharmacomechanical catheter-directed thrombolysis (PCDT) plus anticoagulation...

Value-based payment modifier program not associated with differences in performance program measures

1. Taking into account additional patient characteristics largely influenced performance differences between practices serving high and low risk patients. 2. The value-based payment modifier program...

DNA sequencing may inform diagnosis and management of kidney disease

1. Whole exome sequencing (WES) provided diagnosis for a subset of patients with chronic kidney disease (CKD). 2. Identification of certain mutations, via WES, changed...

Long-term comorbidities in extremely preterm infants with cerebral palsy

1. The lifetime prevalence of cerebral palsy (CP) was estimated to be 10.5% for infants born extremely premature (EP, <27 weeks gestational age), with...

High readmission rates after revascularization for peripheral arterial disease

1. Of patients with peripheral arterial disease (PAD), 17.6% were readmitted within 30 days after being discharged following peripheral arterial revascularization. 2. After standardizing readmission...

Biennial biopsies may be adequate for men under active surveillance for prostate cancer

1. After accounting for differences in surveillance protocols and treatments, researchers found that estimates of risk for biopsy Gleason score (GS) upgrade were not...

Administering naloxone for opioid overdose reversal in out-of-hospital settings appears to be safe and...

1. For reversing opioid overdose, intranasal naloxone of a higher concentration (2 mg/mL) seems to have a similar efficacy to intramuscular naloxone. 2. Lack of...

Brodmann area 25 may have role in causing peri-ictal systolic hypotension in patients with...

1. In this case series of 12 patients with intractable epilepsy, deep brain electrical stimulation of Brodmann area 25 resulted in significant and consistent...
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