Fecal microbiota transplantation improves remission rates in ulcerative colitis

1. In this randomized controlled trial, patients who received a donor fecal microbiota transplant (FMT) had a higher rate of steroid-free remission at 8-weeks...

Disease modifying therapies likely to reduce conversion to secondary progressing multiple sclerosis

1. In this case-control cohort study, treatment with glatiramer acetate, interferon-beta, fingolimod, alemtuzumab, and natalizumab all led to reduced conversion to secondary progressive Multiple...

1 in 5 US women report delayed contraceptive initiation after sexual debut

1. A total of 1 in 5 women in the US reported delayed contraceptive initiation (>1 month after sexual debut), with higher rates of...

Young-onset type 2 diabetes associated with increased risk of hospitalization frequently due to mental...

1. Patients with young-onset type 2 diabetes had higher rates of all-cause hospitalization than usual-onset diabetes. Over one-third of the total hospitalization bed-days were...

Parents often unaware of adolescents’ suicidal thoughts

1. Clinical interviews of adolescents and their parents revealed that half of parents were unaware of their adolescents’ lifetime thoughts of suicide.2. Older adolescent...

The REGROUP trial: endoscopic and open vein-graft harvest associated with similar outcomes

1. Among patients randomized to an open or endoscopic vein-graft harvest technique for coronary-artery bypass graft (CABG) surgery, there was no difference in major...

Medication co-payment vouchers for P2Y12 inhibitors not associated with reduced major adverse cardiovascular events

1. In this randomized controlled trial, medication vouchers were associated with a small increase in patient-reported persistence with P2Y12 inhibitors for patients who had...

The REACH trial: hydroxyurea safe and effective for sickle cell anemia in African children

1. Among sub-Saharan African children with sickle cell anemia (SCA) treated with hydroxyurea, 5.1% experienced dose-limiting toxic events, well below the protocol-specified allowable rate...

Low-dose intracoronary alteplase unlikely to improve outcomes in STEMI patients treated with primary PCI

1. In this randomized controlled trial, low-dose intracoronary alteplase given early during primary percutaneous coronary intervention (PCI) for acute ST-Elevation Myocardial Infarction (STEMI) did...

Plagiocephaly/brachycephaly associated with lower cognitive and academic achievement scores

1. Children with positional plagiocephaly and/or brachycephaly (PPB) had significantly lower scores in global cognitive ability (GCA), nonverbal reasoning, verbal, and working memory scores compared...

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