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Oral remibrutinib hits Phase 3 primary endpoint for inducible hives
1. Oral remibrutinib successfully met its primary endpoint in the Phase III RemIND trial, delivering significant symptom relief for chronic...
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Higher sleep apnea-specific hypoxic burden may predict postoperative cardiovascular complications and mortality in obstructive sleep apnea
1. In this cohort of patients with Obstructive sleep apnea (OSA), a higher sleep apnea-specific hypoxic burden (SASHB) was associated...
Merck and Mayo Clinic launch AI-driven precision medicine lab
1. Merck and Mayo Clinic have launched a strategic collaboration to integrate multimodal clinical data with AI to accelerate drug...
Lifestyle factors including higher body mass index and smoking are associated with changes in left-atrial size and function
1. In this prospective cohort study, lifestyle behaviours, especially higher body mass index (BMI) and smoking, are associated with measurable...
Smartphone-based digital ruler achieved high diagnostic performance for strabismus screening
1. Wang and colleagues developed a system that uses deep learning algorithms to analyze cover tests recorded by suspected strabismus...
Safety and efficacy profile of first-in-class oral p53 reactivator rezatapopt
1. In this phase 1-2 single-group trial, the p53 reactivator rezatapopt was well-tolerated in adults with solid tumors harboring the...
Ex vivo gene therapy for cystinosis had acceptable safety and improved disease biomarkers
1. In this phase 1–2 open-label study, autologous lentiviral hematopoietic stem-cell gene therapy for cystinosis was associated with sustained engraftment...
Replacing sedentary time with physical activity may lower risk of all-cause mortality
1. In this prospective cohort, individuals with greater periods of sedentary time have increased risks of all-cause mortality and mortality...
Metformin and ursodeoxycholic acid do not improve long COVID recovery
1. In this randomized controlled trial, neither metformin nor ursodeoxycholic acid improved recovery from long COVID compared with placebo in...
Breast cancer screening with MRI provides modest benefit for high-risk women
1. For women at higher-than-average risk, adding supplemental MRI to DBT provided only modest additional benefit, resulting in a similar...
