Spironolactone use associated with improved outcomes for patients with HFpEF and resistant hypertension

1. Among patients with HFpEF and resistant hypertension, administration of spironolactone was associated with a reduced risk of composite cardiovascular events, all-cause mortality, and...

Ezogabine with potential to slow disease progression for amyotrophic lateral sclerosis in phase 2...

1. Dose-dependent ezogabine was shown to decrease motor neuron excitability, a marker of disease progression, in patients with amyotrophic lateral sclerosis. Evidence Level Rating: 1...

Cryoballoon ablation for prevention of atrial arrhythmia recurrence

1. Patients with recurrent atrial fibrillation who received cryoballoon ablation were significantly more likely to remain free of subsequent arrhythmia after 1 year compared...

Comparison of laparoscopic percutaneous extraperitoneal closure and laparoscopic intracorporeal suture in pediatric hernia repair

1. Among children requiring inguinal hernia repair, those receiving laparoscopic percutaneous extraperitoneal closure had a faster time to recovery, experienced fewer complications, and had...

Rivaroxaban noninferior to warfarin in patients with atrial fibrillation and bioprosthetic mitral valves

1. Patients who received rivaroxaban had a statistically significantly longer mean time until occurrence of a major clinical event compared to those who received...

Mass distribution of azithromycin shown to increase antibiotic resistance

1. Children in African villages that received scheduled azithromycin displayed increased antibiotic resistance compared to ones that received a placebo. 2. An increase in nonmacrolide...

Asymptomatic transmission of SARS-CoV-2 in young Marine Corps recruits

1. Shared rooms and platoon membership within young Marine Corps recruits were risk factors for transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)...

Diaphragm myopathy found in in critically ill patients with COVID-19

1. Patients with severe COVID-19 demonstrated a unique diaphragm myopathic phenotype compared to non-COVID-19 ICU patients. 2. It is unclear whether or not myopathy is...

Lessons from a Covid-19 outbreak on a naval aircraft carrier

1. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was shown to spread rapidly amongst the U.S.S Theodore Roosevelt crew due to close close-quarter conditions...

Association between maternal breastfeeding satisfaction and postpartum depression

1. Increased breastfeeding satisfaction was 47% higher among mothers who were negative for postpartum depression compared to those who were positive for postpartum depression. Evidence...
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