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Vaccination boosted immunity acquired from previous SARS-CoV-2 infection
1. Two doses of the Pfizer-BioNTech BNT162b2 vaccine were linked to high immediate protection again severe acute respiratory syndrome coronary...
CT associated with lower complication risks than invasive coronary angiography
1. In patients with stable chest pain and intermediate pretest probability of coronary artery disease (CAD), there was no difference...
Treating mild chronic hypertension associated with better pregnancy outcome
1. Treatment of mild chronic hypertension in pregnant women was associated with lower risks of adverse pregnancy outcomes. 2. Treating...
Mitapivat efficacious in treating pyruvate kinase deficiency
1. Compared to placebo, mitapivat was found to be effective in treating hemolytic anemia and increasing hemoglobin levels. 2. Mitapivat...
Single-incision mini-slings effective for urinary incontinence in women
1. Compared to standard midurethral slings, single-incision mini-slings were noninferior in achieving patient-reported success in treating stress urinary incontinence at...
Liposomal amphotericin B noninferior to standard treatment for cryptococcal meningitis
1. Single-dose liposomal amphotericin B followed by flucytosine and fluconazole was non-inferior in the treatment of cryptococcal meningitis in HIV-positive...
Valoctocogene roxaparvovec gene therapy efficacious for hemophilia A treatment
1. The adeno-associated virus 5 (AAV5)-based gene therapy, valoctocogene roxaparvovec (AAV5-hFVIII-SQ), resulted in sustained factor VIII production, reduced bleeding rates,...
Effectiveness of Covid-19 vaccines waned over timer in North Carolina
1. Three Covid-19 vaccines from Pfizer, Moderna, and Johnson & Johnson provided durable protection against hospitalization and death. 2. However,...
Clinically important troponin I threshold for mortality after cardiac surgery
1. For patients undergoing only a coronary-artery bypass grafting (CABG) or aortic-valve operation, a troponin I level 218 times the...
LentiGlobin efficacious for sickle cell disease hemolysis and vaso-occlusion
1. LentiGlobin gene therapy resulted in sustained production of the modified anti-sickling hemoglobin, HbAT87Q. 2. LentiGlobin led to reduced hemolysis...
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