Hip replacement superior to resistance training in severe hip osteoarthritis
1. In this randomized controlled trial, total hip replacement (THR) was superior to resistance training in improving hip pain and...
Adjuvant dabrafenib and trametinib improve survival in stage III melanoma
1. After almost 10 years of follow-up, adjuvant dabrafenib and trametinib improved relapse-free and metastasis-free survival compared to placebo in...
Cases of neurodevelopmental disorders caused by mutated lncRNA CHASERR
1. Three unrelated children were found to have a de novo deletion in the long non-coding RNA (lncRNA) CHASERR, which...
Kidneys from donors with HIV have good safety outcomes in persons with HIV
1. Among patients living with human immunodeficiency virus (HIV) who received deceased donor kidney transplants, kidneys from donors with HIV...
ANGPLT3 interfering RNA therapy reduces triglyceride levels in mixed hyperlipidemia
1. Zodasiran, an RNA interference (RNAi) therapy targeting angiopoietin-like 3 (ANGPTL3), resulted in a dose-dependent reduction in ANGPTL3 and triglyceride...
Pomalidomide effective in reducing epistaxis in hereditary hemorrhagic telangiectasia
1. Among patients with hereditary hemorrhagic telangiectasia (HHT), pomalidomide significantly reduced the severity of epistaxis and improved quality of life....
Ziresovir reduces the severity of respiratory syncytial virus in hospitalized infants
1. Ziresovir, an antiviral drug targeted at respiratory syncytial virus (RSV), was superior to placebo in reducing signs and symptoms...
Combination of doxorubicin-trabectedin with trabectedin improves leiomyosarcoma outcomes
1. In patients with advanced leiomyosarcoma, a regimen of doxorubicin-trabectedin was superior to doxorubicin alone in improving progression-free and overall...
Neuroprosthesis enables conversational communication in amyotrophic lateral sclerosis
1. A participant with amyotrophic lateral sclerosis (ALS) and severe dysarthria underwent surgical implantation of microelectrode arrays set up to...
Individuals with disorders of consciousness can perform cognitive tasks
1. In a large cohort of individuals with disorders of consciousness exhibiting no observable response to verbal commands, approximately 25%...