Oncology

Reports of high-impact oncology studies by medical professionals

Aprepitant regimen is linked to decreased chemotherapy-induced nausea and vomiting in women

1. Aprepitant in conjunction with palonosetron and dexamethasone is associated with increased antiemetic efficacy during FOLFOX or FOLFIRI chemotherapy in women Evidence Rating Level: 1...

Clinicopathological heterogeneity in triple-negative breast cancers associated with variable prognosis and therapeutic outcomes

1. Heterogeneity in histological profile linked to improved overall survival, chemotherapy response, and clinical course despite triple-negative receptor status in three rare breast cancer...

Lenvatinib plus pembrolizumab for advanced renal cell carcinoma treatment

1. Lenvatinib plus pembrolizumab was superior to sunitinib in overall survival for patients with advanced renal cell carcinoma. 2. Lenvatinib plus pembrolizumab demonstrated longer progression-free...

Tislelizumab plus chemotherapy vs chemotherapy alone as treatment for advanced squamous NSCLC

1. Tislelizumab, a monoclonal antibody and PD1/L1 inhibitor, when combined with chemotherapy, showed significantly prolonged progression free survival and higher objective response rate, compared...

Nivolumab in resected esophageal or gastroesophageal junction cancer improved survival

1. Adjuvant nivolumab significantly improved disease-free survival compared to placebo among patients with resected esophageal or gastroesophageal junction cancer. 2. Adverse events were more common...

Shortened duration of adjuvant chemotherapy in individuals with stage III colon cancer may be...

1. Explicit emulation of a target trial investigating the comparative efficacy of a shortened duration of adjuvant chemotherapy in individuals with stage III colon...

Pirtobrutinib is safe and efficacious in the treatment of relapsed or refractory B-cell malignancies...

1. Bruton’s tyrosine kinase inhibitor pirtobrutinib showed efficacy in the treatment of relapsed or refractory B-cell malignancies such as chronic lymphocytic leukemia, mantle cell...

Whole-genome sequencing more accurate than cytogenetic analysis in myeloid cancers

1. Whole-genome sequencing for myeloid cancers, compared to standard cytogenic analysis, was able to more effectively risk-stratify cytogenic cases. 2. Inconclusive cytogenetic analysis cases were...

Nivolumab and cabozantinib superior to sunitinib for advanced renal-cell carcinoma

1. The combination of nivolumab and cabozantinib was superior to sunitinib in untreated advanced renal-cell carcinoma 2. The combination treatment caused more drug discontinuation compared...

Radiolabeled Lutetium-177 offers higher PSA response versus cabazitaxel in metastatic castration-resistant prostate cancer

1. Radiolabeled Lutetium-177 offered greater PSA response versus current standard of care, cabazitaxel. 2. Fewer grade 3-4 adverse events occurred in patients treated with Lutetium-177...

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