Oncology

Reports of high-impact oncology studies by medical professionals

Progression free survival poorly correlates with health-related quality of life in cancer trials

1. Progression free survival demonstrates poor-correlation with measures of health related quality of life (HRQoL) in oncology trials. 2. Current study demonstrate poor follow-up and...

Quick Take: Association between contemporary hormonal contraception and ovarian cancer in women of reproductive...

Worldwide, more than 100 million women use hormonal methods of contraception. Combined oral contraceptives have previously shown an inverse relationship with ovarian cancer risk....

Tailoring fecal immunochemical tests positivity thresholds by age and sex may help to optimize...

1. Cancer detection among participants was higher with lower positivity thresholds. 2. Sensitivity with conventional fecal immunochemical tests (FIT) thresholds decreased with increasing age and...
Classics Series, Landmark Trials in Medicine

Anastrazole superior to tamoxifen for breast cancer treatment [Classics Series]

1. Postmenopausal women with advanced breast cancer randomized to anastrazole as first-line therapy experienced an increase in time to progression and a more favorable...

Paradigm shift in cancer treatment to targeted therapies

1. HER2 targeted breast cancer treatment has significantly improved prognosis. 2. Novel immune checkpoint therapies have resulted in considerable clinical response for a variety...

Primary HPV testing may detect cervical neoplasms earlier and more accurately than cytology

1. In this Canadian, randomized controlled trial, the use of primary HPV testing compared with cytology resulted in a significantly lower likelihood of CIN3+...

Enzalutamide reduces risk of metastatic prostate cancer in at-risk men

1. Prostate cancer patients with a rapidly risking prostate-specific antigen (PSA) despite chemical or physical castration had lower rates of metastasis when treated with...

Fruquintinib increases overall survival in metastatic colorectal carcinoma

1. In this phase 3 randomized controlled trial, fruquintinib increased median overall survival and progression-free survival compared to placebo in patients with colorectal cancer...

Nonsurgical treatment of small tumor renal cancer may be as effective as radical nephrectomy...

1. Rates of renal insufficiency were highest in patients receiving renal nephrectomy, compared to less invasive treatments. 2. Survival rates for renal nephrectomy and partial...

Exercise linked to reduced mortality in survivors of childhood cancer

1. In this retrospective cohort analysis, adult survivors of childhood cancer demonstrated reduced mortality with increasing levels of vigorous exercise in a week. 2. Increasing...
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