Oncology

Reports of high-impact oncology studies by medical professionals

Combined Encorafenib-Binimetinib-Cetuximab therapy associated with longer overall survival in patients with BRAF V600E-mutated coloreactal...

1. A phase 3 randomized clinical trial showed that combined therapy using a BRAF inhibitor (encorafenib), EGFR monoclonal antibody (cetuximab) and a MEK inhibitor...

Lung cancer screening according to existing guidelines is likely cost-effective

1. In this study comparing three prominent lung cancer screening strategies, all were found to be cost-effective, yielding incremental cost-effectiveness ratios of under $100,000/quality...

Life-gained-based selection for cancer screening may result in superior health outcomes compared to risk-based...

1. In this modelling study, life-gained-based selection of smokers for lung cancer screening resulted in a nearly threefold greater gain in life expectancy per...

Assessment of Combined Nivolumab and Bevacizumab in Relapsed Ovarian Cancer: A Phase 2 Clinical...

1. Nivolumab and bevacizumab combination therapy appears to be efficacious in relapsed epithelial ovarian cancer, especially in patients with platinum-sensitive disease.Evidence Rating Level: 2...

Oxaliplatin-Based Adjuvant Chemotherapy for Rectal Cancer After Preoperative Chemoradiotherapy (ADORE): Long-Term Results of a...

1. Adjuvant FOLFOX improves disease-free survival in patients with pathologic Stage II or III rectal cancer after upfront surgery and preoperative chemoradiotherapy, but is...

Maribavir safety and efficacy for cytomegalovirus infections among transplant recipients

1. This phase 2, parallel-group randomized control trial compared the safety and efficacy profile of maribavir versus valgancicvlovir among patients who received solid organ...

Quick Take: Assessment of laparoscopic distal gastrectomy after neoadjuvant chemotherapy for locally advanced gastric...

1. Patients undergoing laparoscopic distal gastrectomy for locally advanced gastric cancer have better postoperative outcomes when compared to those undergoing traditional open distal gastrectomy.Evidence...

Quick Take: Factors associated with successful discontinuation of immune suppression after allogenic hematopoietic cell...

1. Successful discontinuation of immune suppression after hematopoietic cell transplantation may be less likely in the setting of peripheral blood stem cell grafts, prior...

Quick Take: Efficacy and Long-term Peripheral Sensory Neuropathy of 3 vs 6 Months of...

1. A shortened course of oxaliplatin-based adjuvant chemotherapy for stage III colon cancer was associated with decreased peripheral sensory neuropathy without compromising effectiveness.Evidence Rating...

Quick Take: Breast Cancer Recurrence in the Nipple-Areola Complex After Nipple-Sparing Mastectomy With Immediate...

Nipple-sparing mastectomy (NSM) in the setting of breast cancer preserves the nipple-areola complex (NAC) and breast skin envelope. While previous studies have shown that...
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