Active monitoring compared to maintenance capecitabine is a viable alternative for stable metastatic colorectal...
1. Progression-free survival was extended by the use capecitabine as compared to active monitoring, but at the expense of increased toxicity. There was no...
Gemcitabine with ramucirumab improved overall survival for malignant pleural mesothelioma
1. Compared to the gemcitabine with placebo group, the gemcitabine with ramucirumab group had longer overall survival as a potential second-line treatment for malignant...
Camrelizumab with chemotherapy demonstrated improved overall survival and progression-free survival of esophageal squamous cell...
1. Camrelizumab improved the overall survival and the progression-free survival of esophageal squamous cell carcinoma patients compared to placebo treatment as adjuvants to chemotherapy.
2....
Metagenomic next-generation sequencing of cerebrospinal fluid yielded improved sensitivity and specificity for the detection...
1. Cerebrospinal fluid metagenomic next-generation sequencing, a sequencing method requiring low specimen volume and no preservation of cell integrity, may be used as an...
Biologic teclistamab shows promise in treatment of refractory multiple myeloma in phase 1 drug...
1. Patients on the recommended phase 2 dosage of teclistamab had no dose-limiting adverse events.
2. There was a 65% overall response rate seen in...
Multifocal papillary thyroid carcinoma has a higher risk of recurrence than unifocal cancer
1. Multifocal papillary thyroid carcinoma (PTC) was associated with a higher risk of cancer recurrence than unifocal PTC.
2. Large (>1cm) and small (≤1 cm),...
22q11.22 status is a predictor of the degree of negative outcomes of IKZF1 alteration...
1. 22q11.22 deletion alone was not associated with poor outcomes, but in combination with IKZF1 alteration predicted poor outcomes in pediatric B-cell acute lymphoblastic...
Physician-directed genetic screening to evaluate personal risk for medically actionable disorders
1. 15.5% of individuals undergoing primary genetic risk screening testing positive for a genetic variant associated with a preventable monogenic disorder.
2. 49.8% of individuals...
Younger adults with extremity soft-tissue sarcoma may be more likely to receive chemotherapy and...
1. Age group was not significantly associated with variations in treatment for extremity soft-tissue sarcoma decisions, except for the use of chemotherapy and radiation...
Hypofractionated image-guided radiotherapy non-superior to conventional radiotherapy for patients with stage II/III non-small cell...
1. Hypofractionated image-guided radiotherapy was not superior to conventionally fractionated radiotherapy monotherapy for patients with stage II/III non-small cell lung cancer ineligible for concurrent...
