Anastrazole superior to tamoxifen for breast cancer treatment [Classics Series]
1. Postmenopausal women with advanced breast cancer randomized to anastrazole as first-line therapy experienced an increase in time to progression and a more favorable...
Paradigm shift in cancer treatment to targeted therapies
1. HER2 targeted breast cancer treatment has significantly improved prognosis.
2. Novel immune checkpoint therapies have resulted in considerable clinical response for a variety...
Primary HPV testing may detect cervical neoplasms earlier and more accurately than cytology
1. In this Canadian, randomized controlled trial, the use of primary HPV testing compared with cytology resulted in a significantly lower likelihood of CIN3+...
Enzalutamide reduces risk of metastatic prostate cancer in at-risk men
1. Prostate cancer patients with a rapidly risking prostate-specific antigen (PSA) despite chemical or physical castration had lower rates of metastasis when treated with...
Fruquintinib increases overall survival in metastatic colorectal carcinoma
1. In this phase 3 randomized controlled trial, fruquintinib increased median overall survival and progression-free survival compared to placebo in patients with colorectal cancer...
Nonsurgical treatment of small tumor renal cancer may be as effective as radical nephrectomy...
1. Rates of renal insufficiency were highest in patients receiving renal nephrectomy, compared to less invasive treatments.
2. Survival rates for renal nephrectomy and partial...
Exercise linked to reduced mortality in survivors of childhood cancer
1. In this retrospective cohort analysis, adult survivors of childhood cancer demonstrated reduced mortality with increasing levels of vigorous exercise in a week.
2. Increasing...
Isolated mild/moderate thrombocytopenia may not require intervention
1. In a review of children who presented to a specialist hematology clinic with isolated mild or moderate low platelet counts, though causes were...
Survey-based priming intervention linked to improved communication and goals-of-care discussions amongst patient-clinician pairs
1. Goals-of-care (GOC) discussions were linked to improved patient outcomes and reduction of intensity in end-of-life care. The current study demonstrated that a survey-based...
Patients with advanced adenomas are at increased risk of developing colorectal cancer
1. Patients with advanced adenomas identified on flex sigmoidoscopy had a significantly increased risk of death from colorectal cancer (CRC) compared to those with...
