Statins may lower the risk of heart failure associated with anthracycline-based chemotherapy
1. In early breast cancer, exposure to statins during anthracycline-based chemotherapy was associated with a significantly lower risk of heart failure after 5 years.
2....
COVID-19 susceptibility may be increased in patients with hematological malignancies compared to solid organ...
1. Patients with hematological malignancies were found to be at an increased risk of COVID-19 and were more likely to require admission to the...
Patients with hematological malignancies and concomitant COVID-19 have worse health outcomes
1. Older age, progressive disease status, diagnosis of acute myeloid leukemia, non-Hodgkin lymphoma, or plasma cell neoplasms, and severe or critical COVID-19 at admission...
Allogeneic anti-CD19 T cell therapy shows a manageable safety profile in pediatric and adult...
1. In two phase 1 studies, allogenic anti-CD19 CAR T cell (UCART19) treatment showed a manageable safety profile with relapsed or refractory B-cell acute...
Association between low density lipoprotein and all cause and cause specific mortality in Denmark
1. There is a U-shaped association of LDL-C levels and risk of all-cause mortality with the lowest risk at LDL-C levels of 3.6 and...
Pembrolizumab plus chemotherapy improves survival in patients with metastatic triple-negative breast cancer
1. First line treatment with pembrolizumab-chemotherapy showed significant improvement in progression-free survival compared to chemotherapy alone in patients with metastatic triple-negative breast cancer and...
Weekly selinexor, bortezomib, and dexamethasone demonstrates improved survival in treatment-refractory multiple myeloma
1. A once-per-week regime of selinexor, bortezomib and dexamethasone was associated with significantly improved progression-free survival versus current standard of care.
2. Although the once-per-week...
Major birth defects and chromosomal abnormalities significantly associated with increased cancer risk
1. The association between major birth defects and cancer risk was present in children, adolescents, and adults, although the risk was lower in adults.
2....
No difference in survival after laparoscopic versus open liver resection for colorectal metastases
1. The rates of 5-year overall survival were found to differ by less than a percentage point between patients in the laparoscopic group and...
Effectiveness of lorlatinib in advanced anaplastic lymphoma kinase-positive lung cancer
1. In this randomized, double-blind, phase three trial, progression-free survival was higher in patients treated with lorlatinib compared with crizotinib.
2. Lorlatinib treated patients had...
