Fecal microbiota transplantation improves remission rates in ulcerative colitis
1. In this randomized controlled trial, patients who received a donor fecal microbiota transplant (FMT) had a higher rate of steroid-free remission at 8-weeks...
Disease modifying therapies likely to reduce conversion to secondary progressing multiple sclerosis
1. In this case-control cohort study, treatment with glatiramer acetate, interferon-beta, fingolimod, alemtuzumab, and natalizumab all led to reduced conversion to secondary progressive Multiple...
Young-onset type 2 diabetes associated with increased risk of hospitalization frequently due to mental...
1. Patients with young-onset type 2 diabetes had higher rates of all-cause hospitalization than usual-onset diabetes. Over one-third of the total hospitalization bed-days were...
The REACH trial: hydroxyurea safe and effective for sickle cell anemia in African children
1. Among sub-Saharan African children with sickle cell anemia (SCA) treated with hydroxyurea, 5.1% experienced dose-limiting toxic events, well below the protocol-specified allowable rate...
The VITAL trial: Omega-3 supplementation does not reduce risk of cardiovascular events
1. Healthy adult patients randomized to receive marine n-3 fatty acids (omega-3) experienced similar rates of adverse cardiovascular events as those receiving a placebo...
The REDUCE-IT trial: Icosapent ethyl reduces ischemic event risk in patients with hypertriglyceridemia despite...
1. After a median follow-up of 4.9 years, patients with elevated triglyceride levels despite statin use treated with icosapent ethyl had a lower risk...
Quick Take: Risk of Depression and Anxiety in Adults With Cerebral Palsy
The motor disturbances seen in patients with cerebral palsy (CP) may also be comorbid with other issues including behavioural disturbance, cognitive difficulties, sensory impairments,...
Long-term glucosamine sulfate likely improves pain and function in knee osteoarthritis
1. In this systematic review and meta-analysis of patients with knee osteoarthritis (OA) receiving a variety of pharmacologic treatments, glucosamine sulfate was associated with...
Relatives of patients with depression demonstrate impaired cognitive function
1. In this systematic review and meta-analysis, there were significantly lower cognitive functioning scores for those who were first-degree relatives of patients with a...
Aspirin alone likely safest antithrombotic therapy after bioprosthetic aortic valve replacement
1. Aspirin combined with warfarin was linked with increased bleeding but not less thromboembolism compared with aspirin alone after bioprosthetic aortic valve replacement.2. Dual...
