Chronic Disease

Reports of high-impact chronic disease studies by medical professionals

Quick Take: Association of Secondary Preventive Cardiovascular Treatment After Myocardial Infarction With Mortality Among...

Patients with schizophrenia have a shortened life expectancy of 15-20 years compared with the general population, with excess cardiac mortality contributing to this difference....

Quick Take: Phase Ib/II Study of Pembrolizumab and Pegylated Interferon Alfa-2b in Advanced Melanoma

Programmed death-1 (PD-1) inhibitors have shown efficacy in the treatment of melanoma. Pre-existing CD8+ T-cell infiltrate and interferon (IFN) gene signature has been shown...

Quick Take: Intravenous Iron in Patients Undergoing Maintenance Hemodialysis

Patients undergoing hemodialysis typically receive intravenous iron, despite a lack of established clinical efficacy. In this randomized controlled trial, investigators randomized 2141 patients undergoing...

Treatment of hypertension in low-risk patients not linked with improved outcomes

1. In this retrospective cohort study of low-risk patients with mild hypertension, treatment of hypertension was not linked to any change in mortality or...

Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker use linked with decreased mortality after inpatient...

1. In this retrospective cohort study looking at patients admitted to hospital with acute kidney injury, use of angiotensin-converting enzyme inhibitor or angiotensin receptor...

Sildenafil (Viagra) does not improve quality of life for idiopathic pulmonary fibrosis patients treated...

1. In patients with idiopathic pulmonary fibrosis (IPF) and a low diffusion capacity for carbon dioxide (DLCO), the addition of sildenafil to a treatment...

Triple combination regimen appears safe and effective for cystic fibrosis

1. Treatment with the cystic fibrosis transmembrane conductance regulator (CFTR) protein corrector VX-659 in combination with tezacaftor–ivacaftor significantly improved measures of lung function and...

On-demand sildenafil (Viagra) shows limited effectiveness for Raynaud phenomenon

1. Sildenafil may be more effective than placebo for treating patients with Raynaud phenomenon. 2. Patient responses to sildenafil treatment showed substantial heterogeneity. Evidence Rating...

Gastric bypass most effective for weight loss among common bariatric procedures

1. Roux-en-Y gastric bypass was found to be the most effective bariatric procedure reviewed in this study in terms of patient weight loss. 2. The...

Quick Take: Efficacy and cost-effectiveness of nurse-led care involving education and engagement of patients...

Gout is the most common inflammatory-type arthritis worldwide, resulting from the presence of intra-articular sodium urate crystals. In addition to painful gout attacks, resulting...

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