Chronic Disease

Reports of high-impact chronic disease studies by medical professionals

Multiple treatment trajectories exist in adolescent depression

1. In this longitudinal retrospective cohort study, there were multiple treatment trajectories identified among youth with depression. 2. Psychotherapy monotherapy was associated with the lowest...

Non-alcoholic fatty liver disease associated with brain volume loss in middle-aged individuals

1. In this cross-sectional study of middle-aged adults, radiologic evidence of non-alcoholic fatty liver disease (NAFLD) was associated with reduced total cerebral brain volume...

Erenumab linked to decreased episodic migraine frequency: The STRIVE trial

1. Monthly injections of erenumab were associated with reduced migraine frequency, decreased use of acute migraine medication, and decreased migraine burden on daily activities...

Fremanezumab reduces headache frequency in patients with chronic migraine

1. Patients with chronic migraine receiving fremanezumab had significantly fewer migraines and headaches than those receiving placebo after 12 weeks of treatment. 2. Injection-site reactions,...

Tezacaftor-ivacaftor improves pulmonary function in cystic fibrosis patients: The EVOLVE trial

1. Tezacaftor-Ivacaftor significantly improves lung function and reduces the frequency of pulmonary exacerbations in cystic fibrosis (CF) patients homozygous for the Phe508 deletion (Phe508del). 2....

CFTR modulation therapy improves predicted FEV1 in patients with heterozygote residual function cystic fibrosis

1. Absolute change in predicted forced expiratory volume in 1 second (FEV1) improved significantly over a 4 and 8-week period among patients assigned tezacaftor-ivacaftor...

Study suggests testing certain protein combinations can enhance sensitivity of fecal immunochemical test used...

1. Testing for certain combinations of 4 proteins was found to have a sensitivity for detecting colorectal cancer (CRC) and advanced adenomas higher than...

Providing unlimited, immediate access to opioid agonist therapy to people with opioid use disorders...

1. Unlimited, immediate access to opioid agonist treatment (OAT) was shown, through a simulation, to be more cost effective compared to the Observed California...

Cluster analysis identifies phenotype groups for atrial fibrillation with unique clinical outcomes

1. Cluster analysis of a population of patients with atrial fibrillation (AF) identified four unique phenotypes using variables not traditionally associated with AF classification. 2....

Tolvaptan reduces eGFR decline in patients with polycystic kidney disease

1. Estimated glomerular filtration rate (eGFR) declined less over one year of treatment for patients with later-stage autosomal dominant polycystic kidney disease (ADPKD) taking...
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