Chronic Disease

Reports of high-impact chronic disease studies by medical professionals

ICD placement in CKD patients increases hospitalizations without survival benefit

1. Adults with chronic kidney disease (CKD) and heart failure with reduced LVEF who received implantable cardioverter defibrillators (ICDs) did not differ from matched...

Prazosin and placebo exhibit similar efficacy in post-traumatic stress disorder: The PACT trial

1. In patients with nocturnal symptoms of post-traumatic stress disorder (PTSD), prazosin did not significantly reduce nightmares or improve quality of sleep compared to...

Mogamulizumab is safe and possibly effective in HTLV-1-associated myelopathy

1. In this combined phase 1-2a study, mogamulizumab used for treatment of human T-lymphotropic virus type 1 (HTLV-1) associated myelopathy was safe and associated...

Fetal alcohol spectrum disorders likely to be vastly underdiagnosed in US

1. A multisite, cross-sectional study found a large mismatch between previously diagnosed fetal alcohol spectrum disorders and the actual prevalence of cases identified. Evidence Rating...

Preoperatively diagnosed patent foramen ovale linked to increased perioperative stroke risk

1. A preoperatively diagnosed patent foramen ovale was associated with an increased risk of stroke within 30 days of non-cardiac surgery. Evidence Rating Level: 2...

Hot tea consumption associated with increased esophageal cancer risk in high-risk individuals

1. Hot tea consumption in combination with excessive smoking or alcohol use was associated with a higher risk for esophageal cancer. 2. In the absence...

Pharmacist-led extended medication review and follow-up on discharge may decrease risk of readmission

1. In this randomized clinical trial, a pharmacist-led extended intervention, which included medication review, three motivational interviews, and telephone follow-up resulted in significant decreases...

Improved islet encapsulation device for the treatment of type 1 diabetes [PreClinical]

1. A device for islet transplantation for type 1 diabetes was designed and demonstrated to be safe and retrievable in animal models. 2. When tested...

Recurrent Salmonella enterica Typhimurium infection disables host protection against intestinal inflammation [PreClinical]

1. Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with repeated infections. 2. Increased turnover...

Catheter ablation of atrial fibrillation in heart failure reduces mortality and hospitalization: The CASTLE-AF...

1. Compared to medical therapy alone, catheter ablation of atrial fibrillation in patients with heart failure reduced the risk of all-cause mortality and hospitalization. 2....
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