Rivaroxaban and warfarin have similar safety and efficacy in mild atrial fibrillation-related ischemic stroke
1. In this randomized controlled trial, rivaroxaban and warfarin were similar in safety and efficacy when used to prevent early recurrence of stroke in...
Hormone replacement therapy not associated with changes in mortality in post-menopausal women
1. In this analysis of two randomized controlled trials, hormone replacement therapy (HRT) was not associated with a change in all-cause mortality among post-menopausal...
Both total and uninterrupted sedentary time correlated with increased risk of mortality
1. Both a high total amount of sedentary time as well as its accumulation in lengthy, continuous stretches were linked to a higher risk...
Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease
1. In a meta-analysis of randomized trials evaluating blood pressure control in patients with stage 3-5 chronic kidney disease (CKD), more intensive blood pressure...
Cardiovascular benefits of intensive systolic blood pressure control may outweigh risks of chronic kidney...
1. The benefits of intensive systolic blood pressure (SBP) control to cardiovascular and all-cause mortality may outweigh the increased risk of incident chronic kidney...
Risk model underestimates the negative cardiovascular effects of living in a disadvantaged neighborhood
1. Neighborhood socioeconomic position may have a significant impact on major atherosclerotic cardiovascular disease (ASCVD)-related events.
2. Population-based solutions targeted at reducing differences in neighborhood...
Lower target for blood pressure control linked to better cognition
1. In this prospective observational study of patients being treated for hypertension, lower systolic blood pressures were associated with slower cognitive decline.
2. The magnitude...
NT-proBNP guided therapy non-superior for heart failure with reduced ejection fraction
1. In this multicenter, randomized controlled study, the use of NT-proBNP levels to guide medical interventions for heart failure with reduced ejection fraction (HF-rEF)...
CRISPR-Cas9 corrects hypertrophic cardiomyopathy gene mutation in human preimplantation embryos [PreClinical]
1. The gene editing tool CRISPR-Cas9 was used to correct a mutant paternal MYBPC3 allele in human preimplantation embryos.
2. No off-target effects were detected.
Evidence...
Risk of cardiovascular events similar between degludec and glargine in type 2 diabetics: The...
1. Type 2 diabetic patients at high-risk for cardiovascular events treated with the ultra long-acting insulin degludec experienced cardiovascular events at an incidence noninferior...
