Triple combination antihypertension therapy improves blood pressure control for mild-to-moderate hypertension
1. In this randomized controlled trial, patients receiving triple combination antihypertension therapy (TCAT) were more likely to achieve their blood pressure target compared to...
Microtubules linked to cardiomyocyte function in heart failure [PreClinical]
1. Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch.
2. Pharmacologic and genetic strategies to inhibit the detyrosination of...
Idiopathic inflammatory myositis linked to statin exposure
1. In this case control study from Australia, patients with histologically confirmed idiopathic inflammatory myositis (IIM) were more likely to report exposure to statin...
Fewer adverse myocardial events in depressed patients treated with antidepressants after acute coronary syndrome
1. In this prospective cohort study, depressed patients with Acute Coronary Syndrome (ACS) who were treated with escitalopram were less likely to have Major...
Patisiran is effective in treatment of hereditary transthyretin amyloidosis.
1. Patisiran, an RNA interference agent, improved neuropathy symptoms and motor function in patients with hereditary transthyretin amyloidosis after 18 months of use.
2. Types...
Alteplase unlikely to reduce disability after mild stroke without disabling deficits
1. In this randomized controlled trial, administration of alteplase within 3 hours of mild stoke did not lead to a reduction in disability at...
Active EKG monitoring screening leads to earlier diagnosis and treatment for atrial fibrillation compared...
1. In this randomized controlled trial, patients who received immediate atrial fibrillation (AF) monitoring with a new, wearable EKG were more likely to have...
Cross-sex hormone therapy raises risk for vascular events in transgender women
1. Transgender women had higher rates of venous thrombotic events (VTE) with cross-sex hormones.
2. Similar rates of ischemic stroke and myocardial infarction were found...
Placement of implantable cardioverter-defibrillators significantly decreases following Department of Justice investigation
1. In this multicenter, longitudinal, serial cross-sectional analysis, there were 457 hospitals across 43 states that reached a monetary settlement with the Department of...
Quality improvement interventions increase adherence to performance measures for stroke in China
1. In this cluster-randomized clinical trial, quality improvement interventions led to slightly greater adherence of evidence-based, performance measures compared to care as usual for...
