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Dupilumab plus topical corticosteroids are effective in the treatment of childhood atopic dermatitis
1. By week 16, 28% of patients in dupilumab reported clear or almost clear skin (IGA 0-1) compared to 4%...
Risk of myopathy and myalgia among statin users may be small and clinically insignificant
1. 27.1% of patient in the statin group reported muscle pain and weakness compared to 26.6% in the control groups....
SGLT-2 inhibitors provide morbidity and mortality benefits for patients with heart failure
1. SGLT-2 inhibitors reduced time to first hospitalization and cardiovascular death among patients with preserved, mildly reduced, and reduced ejection...
Combination therapy more effective than monotherapy for diabetic peripheral neuropathic pain
1. At week 16, average neuropathic pain score decreased for all three treatment groups. 2. Pain reduction was greater in...
Surgical reconstruction is superior to non-surgical rehabilitation for non-acute anterior cruciate ligament tears
1. Patients in the surgical reconstruction group demonstrated improved knee function at 18 months. 2. Approximately one-third of patients in...
Mitapivat may improve anemia in adults with non-transfusion dependent α- and β-thalassemia
1. 80% of patients receiving mitapivat showed hemoglobin response at 12 weeks. 2. Markers of hemolysis, such as bilirubin and...
Upadacitinib is safe and effective for treatment of non-radiographic axial spondyloarthritis
1. Significantly more patients in the upadacitinib group achieved ASAS40 response at week 14 compared to the placebo group. 2....
Moderate-intensity statin plus ezetimibe is non-inferior to high-intensity statin monotherapy
1. 3-year composite outcome of stroke and cardiovascular disease was comparable between both groups (9.1% combination vs. 9.9% monotherapy). 2....
Abrocitinib is more effective than dupilumab for treatment of moderate-to-severe atopic dermatitis
1. The co-primary endpoints at weeks 2 and 4 were significantly greater with abrocitinib than dupilumab. 2. Overall incidence of...
Pharmacotherapy is effective for acute insomnia but with worse side effect profiles than placebo
1. Eszopiclone and Lemborexant were more efficacious for acute and long-term insomnia compared to placebo but were associated with more...
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