Elagolix with add-back hormone therapy effective in reducing fibroid-associated menstrual bleeding
1. In this pair of identical phase 3 trials involving premenopausal women with uterine fibroids, both elagolix with and without add-back therapy was more...
Teprotumumab may significantly improve outcomes in patients with active thyroid eye disease
1. In this phase 3 trial, patients with thyroid eye disease who received teprotumumab were far more likely to demonstrate a proptosis response compared...
Levothyroxine not effective for treatment of subclinical hypothyroidism symptoms in geriatric patients
1. There was no significant improvement of symptoms associated with subclinical hypothyroidism when subjects aged 80 year or older were given levothyroxine versus the...
Ultra-processed foods linked to increased risk of type 2 diabetes
1. In this prospective cohort study from France, consumption of ultra-processed foods (UPF) was linked to an increased risk of type 2 diabetes (T2D).2....
Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring
1. Children of mothers with diabetes are more likely to develop cardiovascular disease.Evidence Rating Level: 2 (Good)The prevalence of cardiovascular disease (CVD) in children and...
Risk of major adverse cardiovascular events varies with dynamic metabolic syndrome status
1. In this retrospective study involving South Koreans with no history of major adverse cardiovascular events (MACE), persons who developed metabolic syndrome (MetS) within...
Closed-loop insulin delivery systems may improve glycemic outcomes compared to sensor-augmented pumps
1. In this randomized controlled trial, patients with type 1 diabetes who used a closed-loop system spent a greater percentage of time in a...
Testosterone therapy linked to increased risk of venous thromboembolism
1. In this case-crossover study, use of therapeutic testosterone supplementation in men was linked with an increased short-term risk of venous thromboembolism (VTE).2. Associated...
Quick Take: Weight change across adulthood in relation to all cause and cause specific...
1. Maintaining obesity across adulthood, gaining weight from young to middle adulthood, and losing weight from middle to late adulthood, are all associated with...
Quick Take: Glycemic durability of an early combination therapy with vildagliptin and metformin versus...
1. Early combination therapy with vildagliptin and metformin is associated with improved glycemic durability in the setting of newly diagnosed type 2 diabetes.Evidence Rating...
