Quick Take: Efficacy and safety of LY3298176, a novel dual GIP and GLP-1 receptor...
Glucagon-like peptide-1 (GLP-1) potentiates the release of insulin from pancreatic beta cells in a glucose-dependent manner. While pharmacologic studies have shown that GLP-1 delays...
Quick Take: Effect of lorcaserin on prevention and remission of type 2 diabetes in...
There is a strong relationship between body weight and the risk of developing diabetes. Lorcaserin is a selective serotonin 2C receptor agonist that suppresses...
Cost a key consideration of WHO guidelines for diabetes treatment intensification
1. WHO guidelines recommend selecting sulfonylureas as the single best second-line agent for Type 2 Diabetes Mellitus (T2DM) patients.
2. Authors of a commentary on...
Improved cardiovascular health associated with lower incidence of dementia in older adults
1. In this prospective cohort study, older patients with more optimal cardiovascular (CV) health metrics had a lower rate of developing dementia in a...
Optimization of cardiovascular health metrics associated with better cerebrovascular structure and function in young...
1. In this cross-sectional study, young adults with a greater number of modifiable cardiovascular (CV) risk factors at recommended levels was associated with higher...
Bariatric surgery linked to significant reduction in microvascular complications of type 2 diabetes
1. Patients who received gastric bypass surgery had lower rates of diabetic neuropathy at follow up that remained stable throughout the study.
2. Bariatric surgery...
Risk of autism in offspring linked to maternal pregestational diabetes and severe obesity
1. Maternal prepregnancy obesity without pregestational diabetes mellitus (PGDM) or gestational diabetes mellitus (GDM) was associated with a slightly increased risk of having a...
Cross-sex hormone therapy raises risk for vascular events in transgender women
1. Transgender women had higher rates of venous thrombotic events (VTE) with cross-sex hormones.
2. Similar rates of ischemic stroke and myocardial infarction were found...
Newer and older insulin formulations offer similar glucose-lowering effect
1. Basal insulin analogues do not differ significantly in providing glucose control.
2. Some insulin formulations may have more favorable effects on patient weight compared...
Women who experience hypertensive disorders during pregnancy are at high risk for developing high...
1. Women experiencing hypertensive disorders of pregnancy (HDP) had higher rates of cardiovascular disease persisting following the pregnancy.
2. Women with HDP were at particular...
