Whole-genome sequencing more accurate than cytogenetic analysis in myeloid cancers
1. Whole-genome sequencing for myeloid cancers, compared to standard cytogenic analysis, was able to more effectively risk-stratify cytogenic cases.
2. Inconclusive cytogenetic analysis cases were...
mRNA-1273 SARS-CoV-2 vaccine likely effective in nonhuman primates
1. Nonhuman primate vaccination with messenger RNA (mRNA)-1273 induced rapid neutralizing activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).
2. The mRNA-1273 vaccine conferred...
RNA-Binding Protein RBFOX1 May Be Locus for Alzheimer’s Disease Pathogenesis
1. Lower RBFOX1 was associated with greater amyloid burden in the prefrontal cortex.
2. Reduced RBFOX1 was associated with increased rate of decline and reduced...
SEP-363856 reduces symptom severity for acute exacerbation of schizophrenia
1. An oral compound, SEP-363856 was shown to significantly reduce the total score of the Positive and Negative Symptom Scale (PANSS) from baseline compare...
Abnormal cellular metabolism and neuronal pathways in organoids developed from schizophrenic patients
1. In this study of 3-dimensional cerebral organoids of schizophrenia patients and healthy controls, differences were found in mitochrondrial function, response to stimulation and...
SARS-CoV-2 detected in respiratory, fecal, and serum specimens
1. A small number of individuals with confirmed COVID-19 were found to have viral RNA in their feces (29%) and blood (1%). No individuals...
Quick Take: Using Acute Optic Neuritis Trials to Assess Neuroprotective and Remyelinating Therapies in...
1. Acute optic neuritis appears may be an appropriate condition to test neuroprotective and re-myelinating therapies after acute inflammation in multiple sclerosis.
Evidence Rating Level:...
Quick Take: Genomic characterization of metastatic breast cancers
Several late-stage cancers have been shown to acquire genomic alterations during disease evolution. In patients with breast cancer, 20% of metastatic tumors develop ESR1...
Quick Take: Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age
Glucagon-containing α-cells are important for regulating glucose homeostasis along with insulin-secreting β-cells. Glucagon receptor antagonists (GRAs) hold potential as antidiabetic therapies, but there is...
Mavacamten shows promise for treating patients with obstructive hypertrophic cardiomyopathy
1. In this open-label clinical trial, mavacamten was found to reduce mean postexercise left ventricular outflow tract gradient after 12 weeks of treatment, which...
