Microtubules linked to cardiomyocyte function in heart failure [PreClinical]

1. Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch. 2. Pharmacologic and genetic strategies to inhibit the detyrosination of...

Comparative analysis of wounds from oral mucosa versus skin reveals novel therapeutic targets for...

1. Comparative profiling of wounds induced in the oral mucosa versus skin revealed expression of genes that prime the oral mucosa for wound healing....

Viral vector based gene therapies show promise for treating focal epilepsy [PreClinical]

1. Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons. 2. Treatment of rats with a lentiviral...

Human neural stem cell grafts in rhesus monkeys improve motor function after spinal cord...

1. Following cervical spinal cord injury, rhesus monkeys were grafted with human neural progenitor cells. 2. Over the course of 9 months, grafted human neural...

Early diagnosis of HIV infection through analysis of oral fluid [Pre-Clinical]

1. A novel method – Antibody Detection by Agglutination-PCR (ADAP) – was developed to diagnose HIV in oral fluid samples. 2. ADAP is both highly...

Improved islet encapsulation device for the treatment of type 1 diabetes [PreClinical]

1. A device for islet transplantation for type 1 diabetes was designed and demonstrated to be safe and retrievable in animal models. 2. When tested...

Recurrent Salmonella enterica Typhimurium infection disables host protection against intestinal inflammation [PreClinical]

1. Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with repeated infections. 2. Increased turnover...

Novel β-chain-targeting approach for the treatment of lymphoma [PreClinical]

1. The β-chain constant region of the T cell receptor (TCR) was targeted to specifically eliminate a population of malignant T cells. 2. Engineered chimeric...

Thyroid hormone supplementation may be a promising treatment for idiopathic pulmonary fibrosis [PreClinical]

1. An enzyme involved in thyroid hormone activation was found to be elevated in patients with pulmonary fibrosis. 2. Following the treatment of various mouse...

Growth hormone releasing hormone (GHRH) agonists protects against diabetic retinopathy in animal model

1. GHRH and GHRH receptor levels are decreased in diabetic rats and humans. 2. Administration of GHRH agonists to diabetic rats reversed signs of diabetic...
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