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No known association between PCSK9 gene variants and risk of heart failure
1. There was no association detected between PCSK9 gene variants and alterations in cardiac morphology. 2. The odds of having...
Preclinical
Ziltivekimab associated with multiple proatherogenic inflammatory pathways – secondary analysis of the RESCUE trial
1. In this secondary analysis of the RESCUE trial, targeted interleukin 6 (IL-6) ligand inhibition with ziltivekimab was associated with...
Familial natural short sleep mutations may reduce Alzheimer’s Disease pathology in mice [PreClinical]
1. Certain sleep phenotypes, such as those with the familial natural short sleepers (FNSS) mutation, anecdotally do not exhibit the...
Iberdomide elicits SRI-4 response in patients with systemic lupus erythematosus
1. More patients with systemic lupus erythematosus (SLE) who received high doses of iberdomide achieved SRI-4 response compared to placebo...
Valoctocogene roxaparvovec gene therapy efficacious for hemophilia A treatment
1. The adeno-associated virus 5 (AAV5)-based gene therapy, valoctocogene roxaparvovec (AAV5-hFVIII-SQ), resulted in sustained factor VIII production, reduced bleeding rates,...
LentiGlobin efficacious for sickle cell disease hemolysis and vaso-occlusion
1. LentiGlobin gene therapy resulted in sustained production of the modified anti-sickling hemoglobin, HbAT87Q. 2. LentiGlobin led to reduced hemolysis...
Betibeglogene autotemcel gene therapy effective for β-thalassemia
1. Betibeglogene autotemcel (beti-cel) gene therapy resulted in sustained hemoglobin A with a T87Q amino acid substitution (HbAT87Q) in non-β0/β0...
Anti-psychotic medication use during pregnancy not associated with attention-deficit/hyperactivity disorder, autism spectrum disorder or small for gestational age in children
1. Children of mothers who were exposed to anti-psychotics during pregnancy, compared to those never exposed, did not have an...
Delayed antibiotic prescribing is a safe and effective for respiratory tract infections in a community setting
1. There was no difference in follow-up symptom severity between patients who received immediate or delayed antibiotics for respiratory tract...
![Fluorophores enhance visualization for image-guided surgery [PreClinical]](https://s25qthea.wpenginepowered.com/wp-content/uploads/2015/01/FISH_13_21-350x250.jpg)
Whole-genome sequencing more accurate than cytogenetic analysis in myeloid cancers
1. Whole-genome sequencing for myeloid cancers, compared to standard cytogenic analysis, was able to more effectively risk-stratify cytogenic cases. 2....
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