Targeting senescent cells prevents age-related bone loss in mice [PreClinical]

1. When three therapies that eliminate senescent cells were separately tested on aged mice, the animals demonstrated improved bone microarchitecture and increased bone strength. 2....

Adiponectin treats some symptoms of polycystic ovarian syndrome in mice [PreClinical]

1. In mouse models of polycystic ovarian syndrome (PCOS), elevated adiponectin levels ameliorated metabolic dysfunction. 2. However, adiponectin was unable to completely restore reproductive...

CRISPR-Cas9 corrects hypertrophic cardiomyopathy gene mutation in human preimplantation embryos [PreClinical]

1. The gene editing tool CRISPR-Cas9 was used to correct a mutant paternal MYBPC3 allele in human preimplantation embryos. 2. No off-target effects were detected. Evidence...

Small-molecule inhibitor may reduce chemotherapy-associated metastases [PreClinical]

1. In a mouse model of breast cancer, treatment with the chemotherapy paclitaxel (Ptx) enhanced tumor cell dissemination and the formation of micrometastatic lung...

Metformin treats Fragile X syndrome symptoms in mice [PreClinical]

1. Following treatment with metformin, mouse models of Fragile X syndrome (FXS) demonstrated restored neurological signaling activity and synaptic function. 2. Metformin administration reduced...

Combination treatment with calcineurin inhibitors and IL-2 enhances transplant survival [PreClinical]

1. Blood from liver transplant patients treated with a calcineurin inhibitor (CNI) showed increased levels of apoptotic regulatory T cells (Tregs) and lower IL-2...

Drug improves cystic fibrosis pulmonary inflammation and protein function [PreClinical]

1. Thymosin α1 (Tα1), an immunomodulatory drug currently in use, decreased lung inflammation in a mouse model of cystic fibrosis (CF). 2. In mice, administration...

Low-cost biochip isolates cells for clinical diagnosis [PreClinical]

1. Researchers manufactured a microfluidic biochip, using an inkjet printing system to apply conductive nanoparticles to a polymer substrate. 2. The biochip used an electric...

Lipid nanoparticles deliver messenger RNA for hemophilia B protein replacement therapy [PreClinical]

1. A lipid nanoparticle (LNP) delivery system was developed to introduce factor IX (FIX) messenger RNA (mRNA) into a FIX deficient mouse model of...

Next-generation metagenomics sequencing may sleuth out hard-to-find viruses in the blood

1. Next-generation metagenomics detected Human Hepegivirus-1 (HhpgV-1) in a cohort of patients who inject drugs. 2. The clinical significance of detecting HHpgB-1 infection is currently unclear. Evidence...
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