Preclinical

1. This secondary analysis of genetic data emphasized the high number of potentially “pathogenic” variants that are revealed through exome sequencing when analyzing a...

1. Mutations in the gene encoding dystrophin, a large scaffolding protein that supports muscle cell structure, result in Duchenne muscular dystrophy (DMD).2. A gene...

1. Allo-HSCT treatment resulted in significant prolonged reduction in HIV-1 viral reservoirs.2. Mouse models showed adoptive transfer of peripheral CD4+ T cells to immunosuppressed...

1. Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as respiratory depression, opioid-induced hyperalgesia,...

1. Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch.2. Pharmacologic and genetic strategies to inhibit the detyrosination of...

1. Comparative profiling of wounds induced in the oral mucosa versus skin revealed expression of genes that prime the oral mucosa for wound healing....

1. Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons.2. Treatment of rats with a lentiviral...

1. Following cervical spinal cord injury, rhesus monkeys were grafted with human neural progenitor cells.2. Over the course of 9 months, grafted human neural...

1. A novel method – Antibody Detection by Agglutination-PCR (ADAP) – was developed to diagnose HIV in oral fluid samples.2. ADAP is both highly...

1. A device for islet transplantation for type 1 diabetes was designed and demonstrated to be safe and retrievable in animal models.2. When tested...