SARS-CoV-2 detected in respiratory, fecal, and serum specimens
1. A small number of individuals with confirmed COVID-19 were found to have viral RNA in their feces (29%) and blood (1%). No individuals...
Quick Take: Using Acute Optic Neuritis Trials to Assess Neuroprotective and Remyelinating Therapies in...
1. Acute optic neuritis appears may be an appropriate condition to test neuroprotective and re-myelinating therapies after acute inflammation in multiple sclerosis.
Evidence Rating Level:...
Quick Take: Genomic characterization of metastatic breast cancers
Several late-stage cancers have been shown to acquire genomic alterations during disease evolution. In patients with breast cancer, 20% of metastatic tumors develop ESR1...
Quick Take: Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age
Glucagon-containing α-cells are important for regulating glucose homeostasis along with insulin-secreting β-cells. Glucagon receptor antagonists (GRAs) hold potential as antidiabetic therapies, but there is...
Mavacamten shows promise for treating patients with obstructive hypertrophic cardiomyopathy
1. In this open-label clinical trial, mavacamten was found to reduce mean postexercise left ventricular outflow tract gradient after 12 weeks of treatment, which...
Quick Take: Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer...
Alzheimer disease (AD) is characterized by the accumulation of amyloid b (Ab) and tau aggregates in the brain. The progression of AD can be...
Quick Take: Discovery and validation of a prognostic proteomic signature for tuberculosis progression
Tuberculosis (TB) is the leading cause of death by an infectious disease. Identifying affected individuals, particularly if they are asymptomatic, however, remains a challenge...
In utero administration of ivacaftor averts multiorgan disease in ferret model of cystic fibrosis...
1. A G551D missense mutation in the cystic fibrosis transmembrane conductance receptor (CFTR) is a genetic cause of cystic fibrosis (CF).
2. In utero administration...
CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]
1. Haploinsufficiency of Sim1 or Mc4r in the hypothalamus result in an obesity phenotype in mice and humans.
2. In mice, CRISPR-mediated activation (CRISPRa) of...
MYBPC3 haploinsufficiency results in hypertrophic cardiomyopathy by altering myosin head configurations [PreClinical]
1. Truncating mutations in cardiac myosin-binding protein C (MYBPC3) are a common genetic cause of hypertrophic cardiomyopathy.
2. Haploinsufficiency of MYBPC3 results in cardiomyocyte hypercontractility...
