De novo design of artificial IL-2 mimic for the treatment of cancer [PreClinical]

1. IL-2 is a central cytokine that enhances the immune response, with considerable potential for the treatment of cancer.2. A mimic of IL-2 binds...

RNAi suppression of sFLT1 for preeclampsia treatment [PreClinical]

1. The clinical manifestations of preeclampsia result largely from excess circulating soluble vascular endothelial growth factor receptor (sFLT1), produced by the placenta.2. Designer short...

New molecular probes for melanoma imaging and treatment [PreClinical]

1. α-melanocyote stimulating hormone (α -MSH) and its analogs can bind tightly to the melanocortin-1 receptor (MC1R), a G protein-coupled receptor that is overexpressed...

Interpreting genetic variants in kidney and genitourinary disorders will likely require systematic curation of...

1. This secondary analysis of genetic data emphasized the high number of potentially “pathogenic” variants that are revealed through exome sequencing when analyzing a...

Gene therapy targets Duchenne muscular dystrophy in new trial [PreClinical]

1. Mutations in the gene encoding dystrophin, a large scaffolding protein that supports muscle cell structure, result in Duchenne muscular dystrophy (DMD).2. A gene...

Replacement of recipient hematopoietic cells with donor cells may be a major factor in...

1. Allo-HSCT treatment resulted in significant prolonged reduction in HIV-1 viral reservoirs.2. Mouse models showed adoptive transfer of peripheral CD4+ T cells to immunosuppressed...

Designer opioid receptor agonist provides pain relief without opioid side effects in nonhuman primates...

1. Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as respiratory depression, opioid-induced hyperalgesia,...

Microtubules linked to cardiomyocyte function in heart failure [PreClinical]

1. Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch.2. Pharmacologic and genetic strategies to inhibit the detyrosination of...

Comparative analysis of wounds from oral mucosa versus skin reveals novel therapeutic targets for...

1. Comparative profiling of wounds induced in the oral mucosa versus skin revealed expression of genes that prime the oral mucosa for wound healing....

Viral vector based gene therapies show promise for treating focal epilepsy [PreClinical]

1. Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons.2. Treatment of rats with a lentiviral...

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