Preclinical

1. IL-2 is a central cytokine that enhances the immune response, with considerable potential for the treatment of cancer.2. A mimic of IL-2 binds...

1. The clinical manifestations of preeclampsia result largely from excess circulating soluble vascular endothelial growth factor receptor (sFLT1), produced by the placenta.2. Designer short...

1. α-melanocyote stimulating hormone (α -MSH) and its analogs can bind tightly to the melanocortin-1 receptor (MC1R), a G protein-coupled receptor that is overexpressed...

1. This secondary analysis of genetic data emphasized the high number of potentially “pathogenic” variants that are revealed through exome sequencing when analyzing a...

1. Mutations in the gene encoding dystrophin, a large scaffolding protein that supports muscle cell structure, result in Duchenne muscular dystrophy (DMD).2. A gene...

1. Allo-HSCT treatment resulted in significant prolonged reduction in HIV-1 viral reservoirs.2. Mouse models showed adoptive transfer of peripheral CD4+ T cells to immunosuppressed...

1. Mu opioid peptide (MOP) receptor agonists provide effective pain relief, but are associated with severe side effects such as respiratory depression, opioid-induced hyperalgesia,...

1. Post-translational detyrosination of microtubules results in resistance to cardiomyocyte sarcomere shortening and stretch.2. Pharmacologic and genetic strategies to inhibit the detyrosination of...

1. Comparative profiling of wounds induced in the oral mucosa versus skin revealed expression of genes that prime the oral mucosa for wound healing....

1. Seizures are often associated with accumulation of extracellular glutamate due to the synchronous discharges of excitatory neurons.2. Treatment of rats with a lentiviral...