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FDA warns Novo Nordisk over safety reporting violations
1. The FDA issued a warning letter to Novo Nordisk citing failures in required postmarketing adverse event reporting. 2. These...
Preclinical
2 Minute Medicine: Pharma Roundup – Merck and Mayo Clinic’s AI precision medicine lab, Novartis’ remibrutinib hits Phase III hive endpoint, FDA grants priority review for iberdomide in myeloma, oral infigratinib boosts growth velocity in achondroplasia, and shingles vaccine/sildenafil linked to lower Alzheimer’s risk [February 2026]
Merck and Mayo Clinic launch AI-driven precision medicine partnership Merck and Mayo Clinic have officially kicked off a landmark R&D...
A machine learning predictive model accurately predicts the incidence of anastomotic leakage following colon resection
1. An integrative machine learning predictive model based on individual base models can accurately predict the incidence of anastomotic leakage...
GPT-4 performing with superior scores on medical oncology examination questions
1. The large language model, ChatGPT-4, answered 85.0% of examination-style multiple-choice questions on medical oncology correctly, a performance superior to...
The emergence of visual artistic creativity in frontotemporal dementia: a case-control study
1. This case-control study of 689 patients with frontotemporal dementia demonstrated that visual artistic creativity emerged in 17 patients (2.5%),...
No known association between PCSK9 gene variants and risk of heart failure
1. There was no association detected between PCSK9 gene variants and alterations in cardiac morphology. 2. The odds of having...
Ziltivekimab associated with multiple proatherogenic inflammatory pathways – secondary analysis of the RESCUE trial
1. In this secondary analysis of the RESCUE trial, targeted interleukin 6 (IL-6) ligand inhibition with ziltivekimab was associated with...
Familial natural short sleep mutations may reduce Alzheimer’s Disease pathology in mice [PreClinical]
1. Certain sleep phenotypes, such as those with the familial natural short sleepers (FNSS) mutation, anecdotally do not exhibit the...
Iberdomide elicits SRI-4 response in patients with systemic lupus erythematosus
1. More patients with systemic lupus erythematosus (SLE) who received high doses of iberdomide achieved SRI-4 response compared to placebo...
Valoctocogene roxaparvovec gene therapy efficacious for hemophilia A treatment
1. The adeno-associated virus 5 (AAV5)-based gene therapy, valoctocogene roxaparvovec (AAV5-hFVIII-SQ), resulted in sustained factor VIII production, reduced bleeding rates,...
