Recurrent Salmonella enterica Typhimurium infection disables host protection against intestinal inflammation [PreClinical]

1. Repeated gastrointestinal infections in mice, in this case Salmonella enterica Typhimurium (ST), caused intestinal tissue inflammation which escalated with repeated infections.2. Increased turnover...

Novel β-chain-targeting approach for the treatment of lymphoma [PreClinical]

1. The β-chain constant region of the T cell receptor (TCR) was targeted to specifically eliminate a population of malignant T cells.2. Engineered chimeric...

Thyroid hormone supplementation may be a promising treatment for idiopathic pulmonary fibrosis [PreClinical]

1. An enzyme involved in thyroid hormone activation was found to be elevated in patients with pulmonary fibrosis.2. Following the treatment of various mouse...

Growth hormone releasing hormone (GHRH) agonists protects against diabetic retinopathy in animal model

1. GHRH and GHRH receptor levels are decreased in diabetic rats and humans.2. Administration of GHRH agonists to diabetic rats reversed signs of diabetic...

Targeting senescent cells prevents age-related bone loss in mice [PreClinical]

1. When three therapies that eliminate senescent cells were separately tested on aged mice, the animals demonstrated improved bone microarchitecture and increased bone strength.2....

Adiponectin treats some symptoms of polycystic ovarian syndrome in mice [PreClinical]

1. In mouse models of polycystic ovarian syndrome (PCOS), elevated adiponectin levels ameliorated metabolic dysfunction.2. However, adiponectin was unable to completely restore reproductive...

CRISPR-Cas9 corrects hypertrophic cardiomyopathy gene mutation in human preimplantation embryos [PreClinical]

1. The gene editing tool CRISPR-Cas9 was used to correct a mutant paternal MYBPC3 allele in human preimplantation embryos.2. No off-target effects were detected.Evidence...

Small-molecule inhibitor may reduce chemotherapy-associated metastases [PreClinical]

1. In a mouse model of breast cancer, treatment with the chemotherapy paclitaxel (Ptx) enhanced tumor cell dissemination and the formation of micrometastatic lung...

Metformin treats Fragile X syndrome symptoms in mice [PreClinical]

1. Following treatment with metformin, mouse models of Fragile X syndrome (FXS) demonstrated restored neurological signaling activity and synaptic function.2. Metformin administration reduced...

Combination treatment with calcineurin inhibitors and IL-2 enhances transplant survival [PreClinical]

1. Blood from liver transplant patients treated with a calcineurin inhibitor (CNI) showed increased levels of apoptotic regulatory T cells (Tregs) and lower IL-2...

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