Quick Take: Glucagon Receptor Antagonist–Stimulated α-Cell Proliferation Is Severely Restricted With Advanced Age

Glucagon-containing α-cells are important for regulating glucose homeostasis along with insulin-secreting β-cells. Glucagon receptor antagonists (GRAs) hold potential as antidiabetic therapies, but there is...

Mavacamten shows promise for treating patients with obstructive hypertrophic cardiomyopathy

1. In this open-label clinical trial, mavacamten was found to reduce mean postexercise left ventricular outflow tract gradient after 12 weeks of treatment, which...

Quick Take: Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer...

Alzheimer disease (AD) is characterized by the accumulation of amyloid b (Ab) and tau aggregates in the brain. The progression of AD can be...

Quick Take: Discovery and validation of a prognostic proteomic signature for tuberculosis progression

Tuberculosis (TB) is the leading cause of death by an infectious disease. Identifying affected individuals, particularly if they are asymptomatic, however, remains a challenge...

In utero administration of ivacaftor averts multiorgan disease in ferret model of cystic fibrosis...

1. A G551D missense mutation in the cystic fibrosis transmembrane conductance receptor (CFTR) is a genetic cause of cystic fibrosis (CF). 2. In utero administration...

CRISPR-mediated gene activation rescues obesity caused by haploinsufficiency [PreClinical]

1. Haploinsufficiency of Sim1 or Mc4r in the hypothalamus result in an obesity phenotype in mice and humans. 2. In mice, CRISPR-mediated activation (CRISPRa) of...

MYBPC3 haploinsufficiency results in hypertrophic cardiomyopathy by altering myosin head configurations [PreClinical]

1. Truncating mutations in cardiac myosin-binding protein C (MYBPC3) are a common genetic cause of hypertrophic cardiomyopathy. 2. Haploinsufficiency of MYBPC3 results in cardiomyocyte hypercontractility...

De novo design of artificial IL-2 mimic for the treatment of cancer [PreClinical]

1. IL-2 is a central cytokine that enhances the immune response, with considerable potential for the treatment of cancer. 2. A mimic of IL-2 binds...

RNAi suppression of sFLT1 for preeclampsia treatment [PreClinical]

1. The clinical manifestations of preeclampsia result largely from excess circulating soluble vascular endothelial growth factor receptor (sFLT1), produced by the placenta. 2. Designer short...

New molecular probes for melanoma imaging and treatment [PreClinical]

1. α-melanocyote stimulating hormone (α -MSH) and its analogs can bind tightly to the melanocortin-1 receptor (MC1R), a G protein-coupled receptor that is overexpressed...

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