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Long-acting cabotegravir significantly decreases incidence of HIV compared to daily oral tenofovir
1. Cabotegravir was shown to be superior to TDF-FTC in preventing HIV infection in women. 2. Both drugs were well...
Abiraterone plus prednisone improves survival in patients with de novo metastatic castration-sensitive prostate cancer
1. A combination of androgen deprivation therapy, docetaxel, and abiraterone (“triplet therapy”) had the best overall survival and progression-free survival...
More severe symptoms and hospitalizations seen during period of COVID-19 delta variant dominance compared to omicron
1. Loss of sense of smell was more common during a period of delta dominance, while sore throat was more...
Radiofrequency renal denervation produces long-lasting reductions in blood pressure
1. The intervention group saw a 10 mmHg greater reduction in 24-h mean systolic blood pressure compared to the sham...
Fewer hospital admissions and death were seen with SARS-CoV-2 Delta (B.1.617.2) compared to Omicron (B.1.1.529) variant infections
1. The risk of hospitalization and death was lower among cases infected with Omicron variant compared to Delta. 2. In...
Presence of second midwife during the second active stage of labour reduces the risk of severe perineal trauma
1. Severe perineal trauma occurred in 5.7% of patients with one midwife and 3.9% of patients with two midwives during...
Single-dose Ad26.COV2.S reduces risk of COVID-related hospitalization and death in South African healthcare workers
1. Single-dose of Ad26.COV2.S reduces risk of COVID-related hospitalization by 67% compared to matched unvaccinated control group. 2. Breakthrough infections...
Cardiosphere-derived cell therapy slows disease progression in Duchenne muscular dystrophy
1. Cardiosphere-derived cell therapy (CAP-1002) slowed loss of upper limb function by 71% compared to placebo in patients with Duchenne...
Garadacimab significantly reduces frequency of hereditary angioedema exacerbations
1. Garadacimab significantly reduced the number of monthly attacks in patients with hereditary angioedema compared to placebo. 2. No serious...
Faricimab noninferior to aflibercept for treatment of neovascular age-related macular degeneration
1. In both trials, faricimab was demonstrated to be non-inferior to aflibercept at improving visual acuity in neovascular age-related macular...
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