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Linzagolix significantly reduces heavy menstrual bleeding in women with uterine fibroids
1. Linzagolix (100 mg and 200 mg) significantly reduced heavy menstrual bleeding in women with uterine fibroids compared to placebo....
Antihypertensives reduce the rate of progressive aortic root dilation in Marfan syndrome
1. Compared to control, ARBs reduced the annual rate of increase of the aortic root Z score by approximately one-half....
Individuals with autoimmune diseases may have an increased risk for cardiovascular diseases
1. An increased incidence of new cardiovascular disease was seen in individuals with autoimmune disease compared to those without. 2....
Monkeypox data in Spain suggests close contact as main method of transmission
1. Clinical evidence, high viral loads, and participant history suggests close contact as the main transmission method of monkeypox in...
Half-dose antenatal betamethasone is inferior to full dose for preventing usage of neonatal surfactant
1. Half-dose antenatal betamethasone did not meet the noninferiority criteria when compared to full dose at preventing the primary outcome...
Mepolizumab reduced exacerbations in children with exacerbation-prone eosinophilic asthma
1. There was a 27% reduction of severe asthma exacerbations in children treated with mepolizumab compared to control. 2. There...
Endoscopic sleeve gastroscopy effective for excess weight loss in type 1 and 2 obesity
1. Approximately three-quarters (77%) of patients who underwent endoscopic sleeve gastroscopy with lifestyle modifications achieved 25% or more reduction in...
Baricitinib reduces mortality risk in patients hospitalized with COVID-19
1. Baricitinib with usual care was associated with a 13% proportional reduction in mortality compared to treatment as usual care...
Methotrexate reduces functional burden of disease in patients with arthralgia at-risk of developing rheumatoid arthritis
1. Compared to placebo, methotrexate did not significantly reduce the risk of the development of clinical arthritis in at-risk patients....
Intravenous tenecteplase non-inferior to alteplase for thrombolysis in acute ischemic stroke
1. IV tenecteplase was non-inferior to IV alteplase for treatment of acute ischemic stroke regarding the primary outcome of a...
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