#VisualAbstract: Disease-Modifying Effects of a Novel Cathepsin K Inhibitor in Osteoarthritis

1. In this double-blind phase 2a trial, cathepsin K inhibitor MIV-711 did not show a significant benefit in reducing pain but proved effective in...

#VisualAbstract: Phase 3 Efficacy Analysis of a Typhoid Conjugate Vaccine Trial in Nepal

1. In Nepal, the typhoid conjugate vaccine has proven to be very effective in protecting against typhoid fever.2. The typhoid antibody titers more than...

#VisualAbstract: A Texting Intervention in Latino Families to Reduce ED Use

1. In this randomized controlled trial, a Spanish-language texting application significantly decreased the rate of emergency room (ER) visits among the intervention population.2. A...

#VisualAbstract: Overall Survival with Osimertinib in Untreated, EGFR-Mutated Advanced NSCLC

1. After a 3-year follow-up to a phase 3 trial, the epidermal growth factor receptor-tyrosine kinase inhibitor osimertinib resulted in a longer median overall...

#VisualAbstract: Obeticholic acid for the treatment of non-alcoholic steatohepatitis

1. Obeticholic acid, a farnesoid X receptor agonist, prompts fibrosis improvement in patients with non-alcoholic steatohepatitis (NASH)Evidence Rating Level: 1 (Excellent)Non-alcoholic steatohepatitis (NASH) is an...

#VisualAbstract: Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X)

1. Ixekizumab, an IL-17 inhibitor, elicits disease response in patients with non-radiographic active axial spondyloarthritis who have failed treatment with NSAIDs.Evidence Rating Level: 1 (Excellent)Axial...

#VisualAbstract: Safety and immunogenicity of the oral, inactivated, enterotoxigenic Escherichia coli vaccine ETVAX in...

1. Enterotoxigenic Escherichia coli vaccination may provide significant immunogenic benefits in young children and infants in low- and middle-income countries with minimal associated toxicity.Evidence...

#VisualAbstract: Risk of Nephrogenic Systemic Fibrosis in Patients With Stage 4 or 5 Chronic...

1. In a systematic review and meta-analysis of the use of group II (low risk) gadolinium-based contrast agents (GBCA) for MRI in patients with...

#VisualAbstract: Treatment Effect of Omalizumab on Severe Pediatric Atopic Dermatitis

1. In treatment-resistant childhood atopic dermatitis, omalizumab significantly reduced the severity of dermatitis and improved quality of life compared to placebo. Evidence Rating Level: 1 (Excellent)Anti-IgE...

#VisualAbstract: Rectal indomethacin dose escalation for prevention of pancreatitis after endoscopic retrograde cholangiopancreatography in...

1. Dose escalation of rectal indomethacin does not provide any benefit in preventing pancreatitis in high-risk patients post-endoscopic retrograde cholangiopancreatography.Evidence Rating Level: 1 (Excellent)Pancreatitis...
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