#VisualAbstract: A Randomized Trial of Progesterone in Women with Bleeding in Early Pregnancy

1. Women with early pregnancy bleeding administered progesterone experienced similar rates of live births occurring after 34 weeks’ gestation as women treated with placebo.2....

#VisualAbstract: Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac...

1. In this randomized controlled trial, intra-cardiac arrest, trans-nasal evaporative cooling did not improve survival with good neurologic outcome at 90 days compared to...

#VisualAbstract: Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers

1. A monoclonal antibody fragment to ticagrelor, PB2452, increased platelet function significantly in healthy patients given the oral P2Y12 inhibitor ticagrelor.2. Adverse effects were mainly...

#VisualAbstract: Randomized Trial of Platelet-Transfusion Thresholds in Neonates

1. Preterm infants given prophylactic platelet transfusions at thresholds below 50,000 platelets per cubic millimeter had higher risks of death or major bleeding after...

#VisualAbstract: Transcatheter Aortic-Valve Replacement with a Balloon-Expandable Valve in Low-Risk Patients

1. This randomized control trial compared post-surgical outcomes between transcatheter aortic-valve replacement (TAVR) with balloon-expandable valves or surgical valve replacement in low- risk surgical...

#VisualAbstract: Intramyocardial Injection of Mesenchymal Precursor Cells and Successful Temporary Weaning From Left Ventricular...

1. In this randomized controlled trial, the injection of mesenchymal precursor cells into the myocardium of patients undergoing a Left Ventricular Assist Device (LVAD)...

#VisualAbstract: A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis

1. A randomized control trial of patients with multidrug resistant tuberculosis found that shorter treatment regimens were noninferior to longer treatment regimens currently recommended...

#VisualAbstract: Overall Survival with Fulvestrant plus Anastrozole in Metastatic Breast Cancer

1. A randomized control trial of patients with hormone receptor-positive metastatic breast cancer compared survival outcomes between patients who received combined anastrozole and fulvestrant...

#VisualAbstract: Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients

1. Among patients with severe aortic stenosis at low-risk for surgery, transcatheter aortic valve replacement (TAVR) with a self-expanding valve was noninferior to surgical...

#VisualAbstract: Effect of a Behavioral Intervention Strategy on Sustained Change in Physical Activity and...

1. In this randomized controlled trial, a behavioral intervention increased physical activity and reduced sedentary activity in type 2 diabetes patients.2. The effects of...
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