#VisualAbstract: Effectiveness of lorlatinib in advanced anaplastic lymphoma kinase-positive lung cancer

1. In this randomized, double-blind, phase three trial, progression-free survival was higher in patients treated with lorlatinib compared with crizotinib. 2. Lorlatinib treated patients had...

#VisualAbstract: Plant-based QVLP influenza vaccine likely non-inferior to commercial inactivated vaccines

1. The plant-based quadrivalent virus-like particle (QVLP) seasonal influenza vaccine provided strong protection against respiratory illness and influenza-like illness. 2. The QVLP vaccine had a...

#VisualAbstract: Post-extubation high-flow nasal cannula associated with higher rates of treatment failure in preterm...

1. Rate of treatment failure within 7 days of extubation was higher in patients that received post-extubation high-flow nasal cannula (HFNC), as compared to...

#VisualAbstract: U.S. National trend of COVID-19 cases in children

1. Children represented a growing percentage of total COVID-19 cases 2. Hospitalization and death remained low amongst children with COVID-19 Evidence Rating Level: 3 (Average) Study Rundown:...

#VisualAbstract: Adjuvant radiotherapy may worsen outcomes compared to salvage radiotherapy post radical prostatectomy

1. Adjuvant radiotherapy was found to increase the risk of urinary incontinence and urethral strictures compared to salvage radiotherapy in patients with prostate cancer. 2....

#VisualAbstract: Efficacy and safety of short-term therapy with indigo naturalis for ulcerative colitis

1. Short-term indigo naturalis therapy demonstrated symptomatic improvement in patients with mild to moderate ulcerative colitis. Evidence Rating Level: 1 (Excellent) Treatment options for ulcerative colitis...

#Visual Abstract: Association between anticoagulation, bleeding, and subsequent cancer diagnoses for patients with atrial...

1. Gastrointestinal, genitourinary, or bronchopulmonary bleeding in anticoagulated patients with atrial fibrillation have been associated with higher rates of respective cancer diagnoses. Evidence Rating Level:...

#VisualAbstract:Adjuvant radiotherapy does not improve survival following prostatectomy in men with localized or locally...

1. There is no evidence that adjuvant radiotherapy improves survival compared with early salvage radiotherapy following radical prostatectomy with localized or locally advanced prostate...

#VisualAbstract: Risk of overcorrection in rapid intermittent bolus vs slow continuous infusion therapies for...

1. There is no difference in overcorrection rate when using slow continuous infusion or rapid intermittent bolus administration of hypertonic saline to correct hyponatremia. 2....

#VisualAbstract: Lopinavir-ritonavir does not improve clinical outcomes in patients hospitalized with COVID-19

1. Compared to standard therapy, patients in the lopinavir-ritonavir treatment group did not show reductions in 28-day mortality and progression to invasive mechanical ventilation...
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