Antibiotic therapy is inferior to surgery for children with uncomplicated appendicitis
1. Treatment failure was greater in the antibiotic group compared to appendicectomy group. 2. Significantly more patients in the antibiotic...
Endovascular therapy improves outcomes in vertebrobasilar stroke despite increased risk of bleeding
1. Patients in the endovascular therapy group achieved greater functional outcomes at 90 days. 2. Endovascular therapy resulted in significantly...
Dazukibart is effective in reducing disease activity in adults with refractory dermatomyositis
1. CDASI-A score at 12 weeks was significantly lower in dazukibart 600 mg versus placebo, suggesting reduced morbidity. 2. Treatment-related...
Catheter-guided aortic valve replacement and angioplasty has favorable outcomes compared to surgical intervention
1. The composite of all-cause mortality, myocardial infarction, and stroke favoured FFR-guided PCI plus TAVI compared to SAVR plus CABG....
Mirikizumab is safe and effective in patients with moderate-to-severe Crohn’s disease
1. The composite of patient-reported clinical response and endoscopic response was significantly greater in mirikizumab versus placebo. 2. Clinical remission...
Beti-cel gene therapy achieves high rates of transfusion independence in severe β-thalassemia
1. 89% of patients achieved transfusion independence with beti-cel gene therapy. 2. There were no serious adverse events or treatment-related...
Balloon-guided catheters are associated with worse outcomes in large vessel thrombectomy
1. Functional recovery at 90 days was lower in the balloon-guided catheter group versus the conventional catheter group. 2. All-cause...
Pembrolizumab with radiotherapy and surgery improves survival in high-risk soft tissue sarcoma
1. Pembrolizumab plus radiotherapy and surgery significantly improved disease-free survival. 2. Grade 3 or higher adverse events were more common...
Radiotherapy and abiraterone improve survival in low-volume metastatic castration-sensitive prostate cancer
1. Progression-free survival improved significantly in patients with low-volume disease who received abiraterone and radiotherapy. 2. The addition of radiotherapy...
Hemodiafiltration reduces mortality compared to hemodialysis in kidney failure with dose-dependent benefits
1. Patients in the hemodiafiltration group reported a significant reduction in all-cause mortality compared to those in the hemodialysis group....