Oncology

Reports of high-impact oncology studies by medical professionals

Quick Take: Randomized Phase II Trial Comparing Site-Specific Treatment Based on Gene Expression Profiling...

Gene expression profiling is a novel approach to identifying where cancers of unknown primary site (CUP) originate. Whether the use of gene expression profiling...

Hematopoietic stem cell transplantation reduces transcranial doppler velocities in children with sickle cell anemia

1. In this nonrandomized controlled intervention study, matched sibling donor stem cell transplantation (MSD-HSCT) was associated with lower transcranial doppler velocities (TCDs) at 1...

Quick Take: Histopathologic Predictors of Survival and Recurrence in Resected Ampullary Adenocarcinoma: International Multicenter...

Ampullary adenocarcinoma, arising at the ampulla of Vater in the duodenum, is a gastrointestinal malignancy often treated with surgical resection with curative intent. However,...

The REACH trial: hydroxyurea safe and effective for sickle cell anemia in African children

1. Among sub-Saharan African children with sickle cell anemia (SCA) treated with hydroxyurea, 5.1% experienced dose-limiting toxic events, well below the protocol-specified allowable rate...

Hybrid minimally invasive esophagectomy associated with lower complication rates compared to open esophagectomy

1. A hybrid minimally invasive esophagectomy approach (Ivor-Lewis esophagectomy) was found to have lower rates of intraoperative and postoperative complications after 30 days as...

Screening all donated blood for Zika virus is not cost-effective in the United States

1. This microsimulation study suggested that screening blood for Zika virus is only cost-effective during the high mosquito season in Puerto Rico.2. The authors...

The VITAL trial: Omega-3 supplementation does not reduce risk of cardiovascular events

1. Healthy adult patients randomized to receive marine n-3 fatty acids (omega-3) experienced similar rates of adverse cardiovascular events as those receiving a placebo...

Quick Take: Neoadjuvant degarelix versus triptorelin in premenopausal patients who receive letrozole for locally...

Ovarian function suppression (OFS) is considered an important aspect of treatment in premenopausal women with advanced endocrine-responsive breast cancer. Degarelix is a gonadotropin-releasing hormone...

Quick Take: Short-term androgen suppression and radiotherapy versus intermediate-term androgen suppression and radiotherapy, with...

The optimal duration of androgen suppression therapy with radiotherapy for locally advanced prostate cancer is unknown. In 2018, the French Canadian Prostate Cancer Study...

Quick Take: Influence of HIV Infection on the Natural History of Hepatocellular Carcinoma: Results...

Hepatocellular carcinoma (HCC) is a rapidly increasing cause of morbidity and mortality in patients affected by HIV. However, the impact of HIV infection on...
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