SHISA3 is epigenetically silenced and its ectopic expression suppresses growth in breast cancer
1. The SHISA3 gene was found to be silenced through promoter methylation at higher levels in breast cancer tissues compared to normal breast tissues.
Evidence...
Stromal Expression of hemopexin is associated with lymph-node metastasis in pancreatic ductal adenocarcinoma
1. Increased expression of the protein hemopexin in stroma of patients with pancreatic ductal adenocarcinoma may be associated with lymph node metastasis.
Evidence Rating Level:...
Impact and prognosis of the expression of IFN-α among tuberculosis patients
1. Expression of IFN-α is found to be lower after successful treatment of tuberculosis.
Evidence Rating Level: 2 (Good)
Tuberculosis (TB) is an infectious disease killing...
Intestinal virome signature associated with severity of nonalcoholic fatty liver disease
1. The gut virome among patients with severe NAFLD was found to be different than those with milder NAFLD. #2. Adding viral diversity to...
Hydroxyurea with dose escalation performs better than fixed-dose hydroxyurea in pediatric sickle cell disease
1. Children with sickle cell disease who received the maximum tolerated dose of hydroxyurea had higher concentrations of hemoglobin and fetal hemoglobin compared to...
Relugolix treatment significantly decreases testosterone levels in advanced prostate cancer
1. Relugolix was shown to significantly decrease testosterone levels for a sustained period of time in male patients with advanced prostate cancer.
2. The risk...
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international...
1. In patients with confirmed SARS-CoV-2 infection within 7 days before or 30 days after surgery, significant mortality was observed, and perioperative pulmonary complications...
Enzalutamide treatment increases median overall survival in non-metastatic prostate cancer
1. Enzalutamide along with androgen-deprivation therapy was shown to significantly increase median overall survival among men with non-metastatic, castration-resistant prostate cancer.
2. Adverse events for...
Incidence of thyroid cancer in World Trade Center exposed firefighters
1. Fire Department World Trade Center-exposed workers demonstrate more asymptomatic thyroid cancers, attributable to occult lesion diagnoses, compared to non-WTC-exposed subjects of the Rochester...
Atezolizumab-bevacizumab treatment increases survival in unresectable hepatocellular carcinoma
1. Combination treatment of atezolizumab and bevacizumab was shown to significantly increase overall survival and progression-free survival outcomes in patients with advanced unresectable hepatocellular...
