Oncology

Reports of high-impact oncology studies by medical professionals

The SOLO1 trial: Olaparib significantly delays progression of advanced ovarian cancer

1. In women with BRCA-associated, newly diagnosed advanced ovarian cancer, olaparib significantly prolonged progression-free survival (PFS) at three years compared to placebo.2. The majority...

New molecular probes for melanoma imaging and treatment [PreClinical]

1. α-melanocyote stimulating hormone (α -MSH) and its analogs can bind tightly to the melanocortin-1 receptor (MC1R), a G protein-coupled receptor that is overexpressed...

Quick Take: Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial

Neoantigens are derived from tumor-specific somatic mutations. As such, they are exempt from immune central tolerance mechanisms and can generate robust immune responses, making...

Sorafenib increases progression-free survival in patients with desmoid tumors

1. After 2 years of treatment with sorafenib, patients with desmoid tumors had significantly increased progression-free survival rates compared to patients randomized to a...

Quick Take: Oral Ixazomib Maintenance Following Autologous Stem Cell Transplantation (TOURMALINE-MM3): A Double-Blind, Randomised,...

Autologous stem cell transplantation (ASCT) is commonly used in the treatment of multiple myeloma, though relapse is extremely common. Ixazomib is a proteasome inhibitor...

Modified FOLFIRINOX results in longer disease-free survival in metastatic pancreatic cancer patients compared to...

1. Randomized control trial of patients with metastatic pancreatic adenocarcinoma demonstrates that adjuvant therapy with a modified FOLFIRINOX regimen results in significantly longer disease-free...

Negative colonoscopy screening linked to reduced risk of colorectal cancer and colorectal cancer-related death

1. Among average-risk adults, negative findings of a screening colonoscopy was linked to reduced risk of colorectal cancer and colorectal cancer related-deaths compared to...

Opioids unlikely to provide clinically meaningful reduction in chronic non-cancer pain

1. In this systematic review and meta-analysis of patients with chronic non-cancer pain, though opioids showed small improvements in pain, physical functioning, and sleep...

Data supports limiting blood transfusions for moderate anemia

1. The authors observed in this retrospective cohort study that transfusion rates decreased among patients from 2010 and 2014.2. Paralleling decreasing transfusion rates, the...

Quick Take: Apixaban to Prevent Venous Thromboembolism in Patients with Cancer

The risk of venous thromboembolism (VTE) is significantly increased in patients with active cancer. While parenteral prophylactic anticoagulation has been shown to reduce the...
licensing as small

All-time hits