1. In two large randomized platform trials, early treatment with nirmatrelvir–ritonavir did not reduce hospitalization or death among mostly vaccinated,...

1. In this randomized controlled trial involving patients with recent noncardioembolic ischemic cerebrovascular accident, asundexian in combination with antiplatelet therapy...

1. A next-generation live-attenuated yellow fever vaccine (vYF) demonstrated noninferior immunogenicity compared to the standard vaccine, with nearly universal seroconversion...

1. In patients with resected stage III mismatch repair-deficient colon cancer, adjuvant atezolizumab plus standard chemotherapy improved disease-free survival compared...

1. In a randomized controlled trial of patients with acute venous thromboembolism, apixaban was associated with a substantially lower risk...

1. In a randomized phase 2–3 trial of patients with resectable high-risk intrahepatic cholangiocarcinoma, neoadjuvant therapy with gemcitabine–oxaliplatin, lenvatinib, and...

1. In this phase 1–2 open-label study, autologous lentiviral hematopoietic stem-cell gene therapy for cystinosis was associated with sustained engraftment...

1. In this randomized controlled trial, once-daily oral enlicitide was associated with sustained reductions in low-density lipoprotein cholesterol levels compared...

1. Among patients with previously untreated programmed death-ligand 1 positive, triple-negative breast cancer, first-line sacituzumab govitecan plus pembrolizumab significantly prolonged...

1. In this open-label phase 1–2 study, pediatric patients with mucopolysaccharidosis type II treated with tividenofusp alfa showed substantial reductions...