PCI beneficial in patients undergoing transcatheter aortic-valve implantation
1. In patients undergoing transcatheter aortic valve implantation (TAVI) for severe aortic stenosis (AS) with stable coronary artery disease (CAD),...
Addition of pembrolizumab to chemotherapy improves early-stage triple-negative breast cancer survival
1. In this randomized controlled trial, among patients with early-stage triple-negative breast cancer (TNBC), the addition of neoadjuvant and adjuvant...
Middle meningeal artery embolization reduces adverse events in patients with subdural hematomas
1. In this randomized controlled trial, among patients with symptomatic nonacute subdural hematoma, embolization of the middle meningeal artery (MMA)...
Hip replacement superior to resistance training in severe hip osteoarthritis
1. In this randomized controlled trial, total hip replacement (THR) was superior to resistance training in improving hip pain and...
Adjuvant dabrafenib and trametinib improve survival in stage III melanoma
1. After almost 10 years of follow-up, adjuvant dabrafenib and trametinib improved relapse-free and metastasis-free survival compared to placebo in...
Cases of neurodevelopmental disorders caused by mutated lncRNA CHASERR
1. Three unrelated children were found to have a de novo deletion in the long non-coding RNA (lncRNA) CHASERR, which...
Kidneys from donors with HIV have good safety outcomes in persons with HIV
1. Among patients living with human immunodeficiency virus (HIV) who received deceased donor kidney transplants, kidneys from donors with HIV...
ANGPLT3 interfering RNA therapy reduces triglyceride levels in mixed hyperlipidemia
1. Zodasiran, an RNA interference (RNAi) therapy targeting angiopoietin-like 3 (ANGPTL3), resulted in a dose-dependent reduction in ANGPTL3 and triglyceride...
Pomalidomide effective in reducing epistaxis in hereditary hemorrhagic telangiectasia
1. Among patients with hereditary hemorrhagic telangiectasia (HHT), pomalidomide significantly reduced the severity of epistaxis and improved quality of life....
Ziresovir reduces the severity of respiratory syncytial virus in hospitalized infants
1. Ziresovir, an antiviral drug targeted at respiratory syncytial virus (RSV), was superior to placebo in reducing signs and symptoms...