Oral azacytidine maintenance therapy improved survival outcomes in patients with acute myeloid leukemia

1. Oral azacytidine also known as CC-486 has been found to improve survival outcomes in patients with acute myeloid leukemia. 2. Frequently reported adverse events...

Increased close contact leads to spread of Andes virus in Argentina

1. Extensive person to person contact demonstrated high viral titer load of Andes orthohantavirus (ANDV) in Argentina. 2. The results indicated that epidemic possibility should...

Increases in p-tau181 in blood plasma associated with progressive, longitudinal neurodegeneration

1. Increases in tau phosphorylated at threonine 181 (p-tau181) in blood plasma were associated with progressive, longitudinal neurodegeneration. 2. Findings of p-tau181 were consistent with...

Gaps in evidence-based therapy use in patients with type 2 diabetes mellitus and atherosclerotic...

1. Significant gaps were found in the use of evidence-based therapies in insured patients with atherosclerotic cardiovascular disease and type 2 diabetes mellitus. Evidence Rating...

Fractional doses of yellow fever vaccines are non-inferior to standard doses in seroconversion at...

1. One-fifth fractional doses from all four live attenuated yellow fever virus vaccines met the non-inferiority criterion. 2. The most common treatment-related adverse events were...

Potential impact of individual exposure histories to endemic human coronaviruses on age-dependent severity of...

1. Based on mathematical modeling, cross-reactivity between SARS-CoV-2 and other endemic human coronaviruses may explain variations in disease severity across age groups. Evidence Rating Level:...

Early, short-term tranexamic acid does not improve clinical outcomes at 6 months in patients...

1. Good clinical outcome (mRS 0-3) was observed in 60% of patients in the tranexamic acid group compared to 64% of patients in the...

Patients with acute coronary symptoms exposed to benzodiazepines have four-fold relative risk of developing...

1. Patients with acute coronary symptoms exposed to benzodiazepines had four-fold relative risk of developing posttraumatic stress disorder, adjusting for symptoms of acute stress...

High fasting insulin levels in children associated with higher rates of psychosis and psychotic...

1. Persistently high fasting insulin levels were associated with psychosis and psychotic disorder later in life. 2. Major increases in body mass index during puberty...

Hydroxychloroquine may not prevent Covid-19 after contact exposure

1. Postexposure hydroxychloroquine therapy did not prevent coronavirus disease 2019 (Covid-19) infection in exposed healthy individuals. 2. Hydroxychloroquine treatment after exposure to a positive case...

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