The PIONEER-HF Trial: Sacubitril-valsartan linked to superior outcomes in acute decompensated heart failure

1. Among patients hospitalized for acute decompensated heart failure with reduced ejection fraction (HFrEF), treatment with sacubitril-valsartan reduced N-terminal pro-B type natriuretic peptide (NT-proBNP)...

Omadacycline is noninferior to moxifloxacin in treating community acquired bacterial pneumonia

1. Intensive care unit (ICU) hospitalized adults with community acquired bacterial pneumonia had comparable clinical responses when taking antibiotic courses of omadacycline, a new...

RNA interference agent givosiran appears safe in phase I trial

1. Among patients with acute intermittent porphyria (AIP), there was no difference in the proportion of any and serious adverse events reported between those...

Children with autism have more sleep problems

1. A case-control study comparing parent-reported sleep problems demonstrated increased odds for sleep problems among children with ASD compared to children in the general...

Quick Take: Impact of scribes on emergency medicine doctors’ productivity and patient throughput: multicentre...

Medical scribes are used in variety of clinical settings to complete clerical tasks otherwise done by a clinician. Limited research has been done concerning...

Quick Take: Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer:...

Breast-conserving surgery or mastectomy followed by radiotherapy is commonly used in the treatment of early-stage breast cancer. There is growing interest in delivering postmastectomy...

Primary care utilization associated with increased high-value care

1. In this survey of patients in the United States, primary care was associated with improved patient experience as well as improvement in rates...

Quick Take: Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind,...

Several recently published guidelines regarding the treatment of C. difficile infection recommend vancomycin as first-line antibiotic treatment. However, given the recent increase in severity...

Porphyria recurrence in a transplant recipient illustrates the need for genetic screening of related...

1. A patient with acute intermittent porphyria received a liver transplant from a brother which was expected to be curative, but her symptoms recurred.2....

Quick Take: Association of Surgical Intervention for Adhesive Small-Bowel Obstruction With the Risk of...

Surgeons are often presented with the challenge of determining the appropriate management for adhesive small bowel obstruction (aSBO). While non-operative management leaves the responsible...

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