Targeted intervention improved Infant Bronchiolitis treatment by deimplementing ineffective management practices

1. Targeting specific ineffective bronchiolitis treatment practices and further educating hospital staff on appropriate treatment was more effective at deimplementing inappropriate treatment, compared to...

Polypill plus aspirin treatment decreases cardiovascular event incidence

1. Polypill plus aspirin treatment was shown to decrease the incidence of cardiovascular events compared to placebo in patients without cardiovascular disease. 2. Adverse events...

Clinical outcomes of infants breastfeeding from mothers with COVID-19

1. A small study of Israeli neonates with COVID-19-positive mothers found no transmission of SARS-CoV-2 to the neonates from feeding on unpasteurized maternal breast...

Initial effects of COVID-19 on patients with end-stage kidney disease

1. Patients with end-stage kidney disease were at increased risk of COVID-19-related mortality, particularly among non-Hispanic Black patients. Evidence Rating Level: 3 (Average) End-stage kidney disease...

Time-limited trials may decrease the length of stay of critically ill patients in the...

1. Time-limited trial interventions in patients with poor prognoses decreased length of stay in ICU, reduced minimally beneficial treatments, and increased communication between clinicians...

Clinicopathological heterogeneity in triple-negative breast cancers associated with variable prognosis and therapeutic outcomes

1. Heterogeneity in histological profile linked to improved overall survival, chemotherapy response, and clinical course despite triple-negative receptor status in three rare breast cancer...

Lenvatinib plus pembrolizumab for advanced renal cell carcinoma treatment

1. Lenvatinib plus pembrolizumab was superior to sunitinib in overall survival for patients with advanced renal cell carcinoma. 2. Lenvatinib plus pembrolizumab demonstrated longer progression-free...

Direct oral anticoagulants more effective in patients with valvular atrial fibrillation

1. Patients who received a direct oral anticoagulant had a lower risk of thromboembolic events and major bleeds compared to patients who received warfarin. 2....

Sutimlimab improved hemoglobin and patient symptoms in cold agglutinin disease

1. Sutimlimab was shown to stop hemolysis, improve hemoglobin levels, and reduce patient fatigue in patients with cold agglutinin disease. 2, Infections and gastrointestinal adverse...

Mood disorders and outcomes of COVID-19 hospitalizations

1. Mood disorder diagnoses prior to hospitalization for COVID-19 was associated with increased risk of in-hospital mortality after Day 12. 2. Prior mood disorders were...

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