Tag: neurology

1. Patients with lacunar acute ischemic stroke treated with low-dose alteplase had a lower incidence of intracranial hemorrhage compared with those treated with standard-dose, but did not experience any benefit with regards to disability or death. Evidence Rating Level: 1 (Excellent) Study Rundown: Patients presenting with acute ischemic strike (AIS) routinely...

Lower risk of dementia in patients with atrial fibrillation taking non-vitamin K antagonist oral anticoagulants: A nationwide population-based cohort study 1. Among patients with incident atrial fibrillation, the use of non-vitamin K antagonist oral anticoagulants compared with warfarin was associated with a decreased risk of dementia. Evidence Rating Level: 2 (Good) While...

Independent and Synergistic Effects of High Blood Pressure and Obesity on Retinal Vasculature in Young Children: The Hong Kong Children Eye Study 1. Hypertension and overweight to obese BMI in children were associated with changes in retinal microvasculature. Evidence Rating Level: 2 (Good) Hypertension and obesity, two of the most important risk...

1. Increases in tau phosphorylated at threonine 181 (p-tau181) in blood plasma were associated with progressive, longitudinal neurodegeneration. 2. Findings of p-tau181 were consistent with brain regions characteristic of Alzheimer’s disease, though only among participants with elevated brain amyloid-β. Evidence Rating Level: 2 (Good) Alzheimer’s disease (AD) is the leading form of...

Longitudinal associations of blood phosphorylated tau181 and neurofilament light chain with neurodegeneration in Alzheimer disease 1. Increases in tau phosphorylated at threonine 181 (p-tau181) in blood plasma were associated with progressive, longitudinal neurodegeneration. 2. Findings of p-tau181 were consistent with brain regions characteristic of Alzheimer’s disease, though only among participants with...

1. Carboplatin, given through intracerebral, convection-enhanced delivery, may be a viable adjunct in recurrent high-grade glioma treatment. Evidence Rating Level: 1 (Excellent) Patients with glioblastomas (GBM), which will invariably recur despite maximal therapy, have a poor prognosis, with a median overall survival of 15 months. The current treatment for newly diagnosed...

1. Positive fecal immunochemical test (FIT) results were associated with increased incidences of ischemic stroke, myocardial infarction, and all-cause mortality. Evidence Rating Level: 2 (Good) While fecal immunochemical tests (FIT) is a commonly used and effective screening tool for colorectal cancer (CRC), their clinical use in detecting other diseases is poorly...

Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas 1. Carboplatin, given through intracerebral, convection-enhanced delivery, may be a viable adjunct in recurrent high-grade glioma treatment. Evidence Rating Level: 1 (Excellent) Patients with glioblastomas (GBM), which will invariably recur despite maximal therapy, have a poor prognosis,...

1. Seizures associated with tuberous sclerosis complex (TSC) were reduced by 30% with add-on cannabidiol treatment compared to placebo. 2. Oral cannabidiol at 25 mg/kg/day and 50 mg/kg/day were equally efficacious, although the lower dosage resulted in fewer adverse events. Evidence Rating Level: 1 (Excellent) Study rundown: Tuberous sclerosis complex (TSC) is...

1. Plasma concentration of homocysteine was found to not be associated with incident stroke in a case-control, nested study. 2. Both methionine concentration and methionine to homocysteine ratio were associated with a lower risk of incident stoke. Evidence Level Rating: 2 (Good) Stroke is a leading cause of morbidity and mortality worldwide,...