Tag: neurology

1. Dose-dependent ezogabine was shown to decrease motor neuron excitability, a marker of disease progression, in patients with amyotrophic lateral sclerosis. Evidence Level Rating: 1 (Excellent) Associated with the progressive loss of cortical and spinal motor neurons, amyotrophic lateral sclerosis (ALS) portends a poor prognosis. Studies have shown that greater motor...

Association between neuraxial anaesthesia or general anaesthesia for lower limb revascularisation surgery in adults and clinical outcomes: population based comparative effectiveness study 1. Among patients undergoing lower limb revascularization, the use of neuraxial compared with general anesthesia was associated with decreased 30-day all-cause mortality. Evidence Rating Level: 2 (Good) Although endovascular interventions...

1. Partner death was associated with both ischemic stroke and intracerebral hemorrhage in the subsequent five years, though absolute risk differences were small. 2. Risk of intracerebral hemorrhage was particularly elevated within the first 30 days following partner death. Evidence Rating Level: 2 (Good) Stress can have a negative impact on various...

1. Microbleeds increase risk of intracerebral hemorrhage, ischemic stroke, recurrent stroke, and mortality. 2. Microbleeds do not appear to influence the effects of rivaroxaban treatment. Evidence Rating Level: 2 (Good) Cerebral microbleeds are known to be associated with intracerebral hemorrhage and recurrent. Questions have been raised related to antithrombitic treatment for those...

1. Incidence of optic neuritis remained stable in the UK across 22 years. 2. Participants with optic neuritis demonstrated significantly greater odds of several immune-mediated inflammatory diseases (IMIDs), which, in combination, outnumbered cases of multiple sclerosis. 3. Individuals with optic neuritis had significantly greater hazard ratios for several IMIDs, including...

1. Sodium phenylbutyrate-taurursodiol slowed the functional decline in patients with amyotrophic lateral sclerosis. 2. The mean rate of change for slow vital capacity and plasma phosphorylated axonal neurofilament H subunit were not significantly different between the treatment and control groups. Evidence Rating Level: 1 (Excellent) Study Rundown: Amyotrophic lateral sclerosis (ALS) causes...

1. Low-field, portable MRI appears to be a feasible neuroimaging option for patients hospitalized in ICUs and unable to be transported for traditional MRI. 2. All cases of point-of-care MRI, except for one, were in agreement with radiologic findings from traditional MRI and CT. Evidence Rating Level: 2 (Good) Study Rundown: Magnetic...

1. Causes of death reported on death certificates drastically underestimated dementia mortality burden by a factor of 2.7. 2. Non-Hispanic Black persons demonstrated significantly greater mortality burden than non-Hispanic White persons. Evidence Rating Level: 2 (Good) Dementia is a leading cause of death in the US and abroad, with Alzheimer’s disease accounting...

1. In a large, national sample, approximately 37.1% of patients with stroke history had uncontrolled blood pressure. 2. Most patients on medication were taking angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, diuretics, or calcium channel blockers. Evidence Rating Level: 2 (Good) Stroke is ranked as a leading cause of mortality and disability in...

1. Metformin was found to be safe and tolerable in survivors of pediatric brain tumors. 2. Metformin was associated with retention of memory and processing speed abilities, as well as a reduction of white matter loss. Evidence Rating Level: 1 (Excellent) It is believed that endogenous neural precursor cells (NPCs) can promote...