Tag: neurology

1. Causes of death reported on death certificates drastically underestimated dementia mortality burden by a factor of 2.7. 2. Non-Hispanic Black persons demonstrated significantly greater mortality burden than non-Hispanic White persons. Evidence Rating Level: 2 (Good) Dementia is a leading cause of death in the US and abroad, with Alzheimer’s disease accounting...
1. In a large, national sample, approximately 37.1% of patients with stroke history had uncontrolled blood pressure. 2. Most patients on medication were taking angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, diuretics, or calcium channel blockers. Evidence Rating Level: 2 (Good) Stroke is ranked as a leading cause of mortality and disability in...
1. Metformin was found to be safe and tolerable in survivors of pediatric brain tumors. 2. Metformin was associated with retention of memory and processing speed abilities, as well as a reduction of white matter loss. Evidence Rating Level: 1 (Excellent) It is believed that endogenous neural precursor cells (NPCs) can promote...
Characteristics and Strength of Evidence of COVID-19 Studies Registered on ClinicalTrials.gov 1. While there has been a rise in clinical trials on COVID-19, a large proportion of these studies are expected to yield low levels of evidence. Evidence Rating Level: 3 (Average) The rapid and widespread transmission of coronavirus disease 2019 (COVID-19)...
1. Delirium was significantly associated with long-term cognitive decline. 2. Across all studies, delirium groups demonstrated worse cognitive outcomes than control groups. Evidence Rating Level: 2 (Good) Study Rundown: Delirium is viewed as an acute onset, potentially fluctuating state of disorganized thought or altered levels of consciousness. Postoperative recovery can often include...
Click to read the study JAMA Neurology Image: PD ©2020 2 Minute Medicine, Inc. All rights reserved. No works may be reproduced without expressed written consent from 2 Minute Medicine, Inc. Inquire about licensing here. No article should be construed as medical advice and is not intended as such by the...
1. Decreasing amounts of REM sleep was associated with an increased risk of all-cause mortality. 2. The most profound risk was seen among individuals experiencing less than 15% REM sleep at night. Evidence Level Rating: 2 (Good) Sleep disturbances affect tens of millions of adults each year, contributing significantly to the global...
Intracranial Atherosclerosis on 7T MRI and Cognitive Functioning – the SMART-MR study 1. Among patients with vascular disease, high burden of atherosclerotic lesions in the posterior circulation as well as the posterior cerebral artery was associated with poorer memory and executive functioning. Evidence Rating Level: 2 (Good) The individual and societal burden...
1. Early-life cognitive enrichment was associated with decreased Alzheimer’s disease pathology and cognitive decline in late-life. Evidence Rating Level: 2 (Good) Factors such as educational performance and childhood socioeconomic status impact cognitive decline and Alzheimer’s disease- (AD) related pathology later in life. While these are components of early-life cognitive enrichment (ECLE),...
1. This protein-wide association study found that eight specific proteins were associated with cognitive resilience in older adults, pointing toward targets for novel therapies. Evidence Rating Level: 2 (Good) Many primary causes of dementia occur among older adults present without commonly recognized neuropathological signatures. Proteomics can be useful in identifying proteins...