Disease modifying therapies likely to reduce conversion to secondary progressing multiple sclerosis
1. In this case-control cohort study, treatment with glatiramer acetate, interferon-beta, fingolimod, alemtuzumab, and natalizumab all led to reduced conversion to secondary progressive Multiple...
Greater prenatal alcohol exposure trajectories linked to impaired growth and neurodevelopment
1. Five trajectories of prenatal alcohol exposure (PAE) were described and compared; greater PAE was associated with reduced birth weight and length, as well...
Quick Take: Risk of Depression and Anxiety in Adults With Cerebral Palsy
The motor disturbances seen in patients with cerebral palsy (CP) may also be comorbid with other issues including behavioural disturbance, cognitive difficulties, sensory impairments,...
Relatives of patients with depression demonstrate impaired cognitive function
1. In this systematic review and meta-analysis, there were significantly lower cognitive functioning scores for those who were first-degree relatives of patients with a...
Neither haloperidol nor ziprasidone significantly shortens delirium in the ICU
1. Among critically ill patients with delirium in the intensive care unit (ICU), there was no significant difference in the duration of delirium between...
Quick Take: Neoantigen vaccine generates intratumoral T cell responses in phase Ib glioblastoma trial
Neoantigens are derived from tumor-specific somatic mutations. As such, they are exempt from immune central tolerance mechanisms and can generate robust immune responses, making...
Risk of lifetime stroke exhibits notable geographic variation
1. The 2016 Global Burden of Disease Survey data was assessed to evaluate lifetime risk of stroke in numerous countries and territories, providing global...
Quick Take: Sex and Race Differences in the Association of Incident Ischemic Stroke with...
There are large differences in the incidence of stroke among various ethnic groups, as well as between sexes. These differences also vary significantly with...
Opioids unlikely to provide clinically meaningful reduction in chronic non-cancer pain
1. In this systematic review and meta-analysis of patients with chronic non-cancer pain, though opioids showed small improvements in pain, physical functioning, and sleep...
Quick Take: Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic,...
The selective serotonin reuptake inhibitor (SSRI) fluoxetine is commonly used in treating depression and emotional lability after stroke. Results from previous small trials have...
