Gastroenterology

1. Haploinsufficiency of Sim1 or Mc4r in the hypothalamus result in an obesity phenotype in mice and humans.2. In mice, CRISPR-mediated activation (CRISPRa) of...

1. In this retrospective cohort study conducted in Michigan, aspirin therapy combined with warfarin for patients without a clinical indication was associated with increased...

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk...

With an ever-increasing aging general population, older adults have the potential to contribute to an expansion of the donor pool. Organs from older donors...

1. Among patients with acute intermittent porphyria (AIP), there was no difference in the proportion of any and serious adverse events reported between those...

Several recently published guidelines regarding the treatment of C. difficile infection recommend vancomycin as first-line antibiotic treatment. However, given the recent increase in severity...

1. A patient with acute intermittent porphyria received a liver transplant from a brother which was expected to be curative, but her symptoms recurred.2....

Human milk oligosaccharides (HMO) are complex glycans, and are typically non-digestible by humans. They are, however, important substrates for an infant’s gut microbiota, and...

1. In this study of short and long-term outcomes of liver transplants in the United States, the proportion of transplants performed for alcohol-associated liver...

The 5-year survival rate in neurologically impaired children after feeding tube placement was 75.8%. There were no significant differences in unplanned hospital days 2...