Gastroenterology

Reports of high-impact gastroenterology studies by medical professionals

Aspirin therapy combined with warfarin without clinical indication associated with increased bleeding

1. In this retrospective cohort study conducted in Michigan, aspirin therapy combined with warfarin for patients without a clinical indication was associated with increased...

Genetic variants in NUDT15 associated with increased risk of thiopurine-induced myelosuppression

1. In this case-control study of patients of European ancestry with inflammatory bowel disease (IBD), variants in NUDT15 were associated with an increased risk...

Quick Take: Assessment of Trends in Transplantation of Liver Grafts From Older Donors and...

With an ever-increasing aging general population, older adults have the potential to contribute to an expansion of the donor pool. Organs from older donors...

RNA interference agent givosiran appears safe in phase I trial

1. Among patients with acute intermittent porphyria (AIP), there was no difference in the proportion of any and serious adverse events reported between those...

Quick Take: Cadazolid for the treatment of Clostridium difficile infection: results of two double-blind,...

Several recently published guidelines regarding the treatment of C. difficile infection recommend vancomycin as first-line antibiotic treatment. However, given the recent increase in severity...

Porphyria recurrence in a transplant recipient illustrates the need for genetic screening of related...

1. A patient with acute intermittent porphyria received a liver transplant from a brother which was expected to be curative, but her symptoms recurred.2....

Quick Take: Association of maternal probiotic supplementation with human milk oligosaccharide composition

Human milk oligosaccharides (HMO) are complex glycans, and are typically non-digestible by humans. They are, however, important substrates for an infant’s gut microbiota, and...

Contemporary trends and outcomes of liver transplants for alcohol-associated liver disease

1. In this study of short and long-term outcomes of liver transplants in the United States, the proportion of transplants performed for alcohol-associated liver...

Health care use stable after feeding tube placement in children with neurologic impairment

The 5-year survival rate in neurologically impaired children after feeding tube placement was 75.8%. There were no significant differences in unplanned hospital days 2...

Aspirin use associated with reduction in cardiovascular events but increase in bleeding risk

1. In this systematic review and meta-analysis, while aspirin use among patients without cardiovascular disease was associated with fewer adverse cardiovascular events, it was not...
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