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![Shorter moxifloxacin-containing regimens ineffective for treating TB [REMoxTB trial]](data:image/svg+xml;base64,PHN2ZyB2aWV3Qm94PSIwIDAgMSAxIiB3aWR0aD0iMSIgaGVpZ2h0PSIxIiB4bWxucz0iaHR0cDovL3d3dy53My5vcmcvMjAwMC9zdmciPjwvc3ZnPg==)
Near-point-of-care molecular test accurately detects pulmonary tuberculosis
1. In patients with presumptive pulmonary tuberculosis, the MiniDock MTB molecular test using sputum and tongue swabs showed diagnostic accuracy...
Nirmatrelvir–ritonavir does not improve severe outcomes in adults vaccinated against COVID-19
1. In two large randomized platform trials, early treatment with nirmatrelvir–ritonavir did not reduce hospitalization or death among mostly vaccinated,...
Triple low-dose antihypertensive pill reduced recurrent stroke after intracerebral hemorrhage
1. In clinically stable patients with prior intracerebral hemorrhage, a fixed-dose combination pill containing three low-dose antihypertensive agents reduced recurrent...
Asundexian may reduce recurrent ischemic stroke without increased bleeding risk
1. In this randomized controlled trial involving patients with recent noncardioembolic ischemic cerebrovascular accident, asundexian in combination with antiplatelet therapy...
Adjunctive prednisolone does not reduce coronary artery lesions in Kawasaki disease
1. In this randomized controlled trial involving children with newly diagnosed Kawasaki disease, adjunctive prednisolone did not reduce the incidence...
Mezagitimab appears safe and potentially effective for persistent immune thrombocytopenia
1. In this phase 2 randomized controlled trial, weekly subcutaneous mezagitimab was well-tolerated and associated with symptomatic improvement among patients...
Intensive multifaceted management may improve blood pressure control among low-income patients
1. In this cluster-randomized trial (IMPACTS-BP), patients with longstanding uncontrolled hypertension who underwent multimodal intervention had significantly greater decreases in...
Next-generation yellow fever vaccine shows comparable efficacy to standard vaccine
1. A next-generation live-attenuated yellow fever vaccine (vYF) demonstrated noninferior immunogenicity compared to the standard vaccine, with nearly universal seroconversion...
Atezolizumab may improve disease-free survival in mismatch repair deficiency locally advanced colon cancer
1. In patients with resected stage III mismatch repair-deficient colon cancer, adjuvant atezolizumab plus standard chemotherapy improved disease-free survival compared...
Early surgical valve replacement offers survival benefit in asymptomatic, very severe aortic stenosis
1. This randomized controlled trial involving subjects with asymptomatic, very severe aortic stenosis demonstrated that over a ten-year period, early...
